Repurposed small molecules for use as a bone forming therapeutic during treatment of diseases requiring local bone formation such as fracture repair, spinal fusion, and large segmental bone defects.
There are millions of bone grafting procedures are performed worldwide each year. For spinal fusions the bone healing failure rate may be as high as 40%. The iliac crest is often used as a donor site for autologous grafts but there is a limited supply of iliac bone, there are substantial costs associated with this surgery, and there are many complications that can develop from this type of bone graft harvesting including pain, nerve damage, and hematoma. BMP is capable of inducing new bone formation and do not require harvesting bone from remote sites of the patient. However BMP must be administered at high doses in order to be effective and these high doses are associated with an increasing number of complications including local edema and bone resorption. The high cost and need for high concentrations of BMP create barriers for routine clinical use so there is a need for other compounds that can substitute or complement the use of BMP.
Through an in silico design and screening process, Emory researchers have identified several candidate small molecules that mimic BMP-receptor interaction. The compounds have already been approved by the FDA for other indications. These compounds have shown activity in an alkaline phosphatase cell based assay enhancing sub-optimal doses of BMP. In addition, several compounds have demonstrated the ability to generate de novo bone formation in a non-bone location in vivo in small rodents.
Candidate small molecules were identified in silico and induction of BMP-receptor activity was validated in vitro in pleuripotent cells.
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