Search Results - shih-hui+(joseph)+chao

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Single-cell QUantitative In Situ RT-PCR (SQUIRT-PCR)
Quantitative real-time PCR (qRT-PCR) is a well-established method for amplifying DNA using fluorescent probes. Traditionally this is a step-wise process where an aliquot of the DNA to be amplified is deposited in a chamber and amplified/measured in the chamber. Current systems require significant time for sample preparation including tissue disaggregation,...
Published: 2/23/2023   |   Inventor(s): Deirdre Meldrum, Shih-Hui (Joseph) Chao, Thai Tran, Laimonas Kelbauskas, Jeff Houkal, Andrew Hatch, Weimin Gao, David Richardson
Keywords(s):  
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Quantitative, Multi-Target, Nucleic Acid Analysis Device
Loop-mediated isothermal amplification (LAMP) has great potential for sensitive and selective nucleic acid analysis in resource-limited settings. Amplifications can be easily observed via optical means such as colorimetry which combines robust performance and simple instrumentation. To date, microfluidic approaches based on colorimetric detection have...
Published: 2/23/2023   |   Inventor(s): Rhett Martineau, Jeff Houkal, Shih-Hui (Joseph) Chao, Weimin Gao, Shufang Ci, Deirdre Meldrum
Keywords(s): Agriculture and Animal Science, Bio-Technology, Educational, Environmental, Medical Devices and Imaging
Category(s): Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools, Life Science (All LS Techs)
Chips and Fabrication Methods for Rotation of Live Single Cells or Cell Clusters in Live Cell Computed Tomography
High-dimensional single cell visualization technologies are redefining the way we view and understand biological systems, particularly when identifying and analyzing cancer cells. Some cell defects on the surface or in the interior of a cell just can't be properly evaluated in two dimensional microscopy. However, to completely visualize and quantitatively...
Published: 2/23/2023   |   Inventor(s): Hong Wang, Deirdre Meldrum, Rishabh Shetty, Laimonas Kelbauskas, Shih-Hui (Joseph) Chao
Keywords(s): Bio-Technology, Mechanical and Manufacturing, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Imaging, Life Science (All LS Techs)