Search Results - robert+rose

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Surface Coatings for Spatial Control of Macrophage Fusion
Multinucleated giant cells (MGCs), formed from macrophage fusion, occur as a consequence of a number of pathological conditions in the body. MGC formation can be particularly destructive to synthetic implants, as it etches their surface, and could lead to implant failure. Despite significant research into macrophage fusion, there are many underlying...
Published: 2/23/2023   |   Inventor(s): James Faust, Kyle Doudrick, Wayne Christenson, Robert Ros, Tatiana Ugarova
Keywords(s): Bio-Technology, Materials and Electronics, Medical Devices and Imaging
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs)
Novel Human Papillomavirus (HPV) Chimeric Virus Like Particle (cVLP)-Based Gene Delivery System for Phrophylaxis and Immunotherapy of Infectious Diseases
Applications:As demonstrated in vitro and in vivo results, HPV VLPs, preferably chimeric HPV L1/L2 VLPs, are useful for facilitating delivery and expression of plasmid DNA to antigen presenting cells, and for enhanced induction of immune responses against co-administered plasmid DNA-based immunogens. Results also demonstrate enhanced immune response...
Published: 5/7/2024   |   Inventor(s): Robert Rose, Christine Malboeuf, Youngeun Ellen Lee Son, Christopher Lane
Keywords(s): Vaccine
Category(s): Vaccines
Stable Human Fc Receptor-Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies
Applications:The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages. Although this invention is immediately applicable to dengue virus infection, in principle it is applicable to any viral pathogen whose replication may be enhanced...
Published: 10/28/2024   |   Inventor(s): Jacob Schlesinger, Robert Rose, W.W. Shanaka Rodrigo, Xia Jin
Keywords(s): Vaccine
Category(s): Vaccines