Search Results - rachael+sirianni

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Antibody Fusion Protein and Compositions for Targeting Cancer
Glioblastoma (GBM) is a common and highly aggressive brain tumor that affects over 11,000 patients every year in the US alone. Standard of care includes surgical resection, radiation therapy, and chemotherapy. Even with these aggressive treatments, outcomes remain poor, with a 5 year survival rate of approximately 5%. Many small molecule chemotherapeutics...
Published: 2/23/2023   |   Inventor(s): Joseph Blattman, Tsafrir S Leket-Mor, Rachael Sirianni, Rebecca Cook
Keywords(s):  
Category(s): Life Science (All LS Techs), Cancer Therapeutics, Pharmaceuticals, Protein/Pharma Production in Plants
Formulation of HDACi Loaded ß-Cyclodextrin-poly (ß-amino ester) Nanoparticles
Researchers have developed a novel formulation strategy to encapsulate molecules, including but not limited to histone deacetylase inhibitor (HDACi) drugs in nanoparticle networks composed of beta-cyclodextrin-poly(beta-amino esters). Advantages of this system include high loading capacity, increased in vivo tolerability, sustained release, and improved...
Published: 10/21/2024   |   Inventor(s): Rachael Sirianni
Keywords(s):  
Category(s): Drug Delivery, Therapeutics, Oncology