Search Results - pharmaceuticals+%26+therapeutics

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Cyclic Peptide Triazole Dual Site Inhibitors of HIV-1 Envelope gp120 Glycoproteins
Cyclic Peptide Triazole Dual Site Inhibitors of HIV-1 Envelope gp120 Glycoproteins16-1930*, 14-1731*, and 09-1100PFaculty Inventors: Irwin Chaiken, Professor of Biochemistry & Molecular Biology and Adel Ahmed Rashad, Research Assistant Professor of Biochemistry & Molecular BiologyPAGE TITLECyclic Peptide Triazole Dual Site Inhibitors of HIV-1...
Published: 9/4/2025   |   Inventor(s): Irwin Chaiken
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
CHEC-7 as a Novel sPLA2 Inhibitor for Treating Neurological and Inflammatory Disorders
PAGE TITLECHEC-7 as a Novel sPLA2 Inhibitor for Treating Neurological and Inflammatory DisordersPAGE SUMMARYThe Cunningham lab has discovered that the CHEC peptides are novel potential anti-inflammation therapeutics as inhibitors of secreted phospholipase A2 (sPLA2). Elevated levels of sPLA2 enzymes and the resulting biochemical signaling cascade have...
Published: 9/4/2025   |   Inventor(s): Timothy Cunningham
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
Iminosugar Compounds with Antiflavivirus Activity
Broad-Spectrum Antiviral Iminosugar Compounds for Flaviviruses PAGE SUMMARYFlaviviruses are enveloped, single-stranded RNA viruses that are typically transmitted to humans by mosquitos or ticks. West Nile virus, Hepatitis B virus, Zika virus, yellow fever, and dengue viruses are all flaviviruses. Despite flaviviruses’ prevalence of infection,...
Published: 9/4/2025   |   Inventor(s): Timothy Block
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
Glutamate Modulators to Treat Neurological and Psychiatric Disorders
PAGE TITLE Overview PAGE SUMMARY Prof. Sandhya Kortagere of Drexel University has developed glutamate transport modulators for treating neurological disorders caused by glutamate dysregulation. These small molecule drugs are a platform technology that increase clearance of the neurotransmitter glutamate by cells containing GLT-1, an important modulator...
Published: 9/12/2025   |   Inventor(s): Sandhya Kortagere
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
The Power of Food Scale: A Tool to Evaluate the Psychological impact of the Food Environment Factors that Affect Appetite
PAGE TITLE Overview PAGE SUMMARY Executive Statement: Hunger in humans is driven by basic internal factors like nutritional or caloric deficit but also by external factors like the food environment. as well as more complex behaviors driven by pleasure or desire. The Power of Food Scale (PFS) is a validated measure of hedonic hunger, the...
Published: 2/19/2025   |   Inventor(s): Michael Lowe
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Research Tools & Materials
Geometrically Dynamic Hydrogel-Based Chemically-Eluting Shunt Prosthesis
­ PAGE TITLE Geometrically Dynamic Hydrogel-Based Chemically-Eluting Shunt Prosthesis PAGE SUMMARY Congenital heart abnormalities such as hypoplastic left heart syndromereduce the flow of blood from the heart to the lungs, such that it does not carry sufficient levels of oxygen through the body. Complex surgeries shortly after birth are typically...
Published: 9/12/2025   |   Inventor(s): Randy Stevens, Kara Spiller, Samantha Cassel, Krianthan Govender, Steven Chopski, Amy Throckmorton
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Medical Devices, Diagnostics & Biosensors, Biomaterials & Drug Delivery
A Chimeric MSP-based Malaria Vaccine
PAGE TITLE A chimeric MSP-based malaria vaccine PAGE SUMMARY There are an estimated 200 million people infected with malaria annually, with an estimated 400,000-500,000 deaths, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments, there are artemisinin-resistant...
Published: 2/19/2025   |   Inventor(s): James Burns
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
Echogenic Polymer microcapsules and nanocapsules and methods for production and use thereof
PAGE TITLEOverviewPAGE SUMMARY Methods for producing echogenic polymer microcapsules and nanocapsules for use in diagnostic imaging and delivery of bioactive compounds as well as targeted imaging and delivery to selected tissues and cells are provided. Compositions containing these echogenic polymer microcapsules and nanocapsules for use in diagnostic...
Published: 2/18/2025   |   Inventor(s): Margaret Wheatley, Dalia El-Sherif
Keywords(s): Cancer therapeutic
Category(s): Pharmaceuticals & Therapeutics, Medical Devices, Diagnostics & Biosensors, Biomaterials & Drug Delivery
Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
PAGE TITLEOverviewPAGE SUMMARY A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells....
Published: 9/8/2025   |   Inventor(s): Gennady (gary) Friedman, Robert Levy, Ivan Alferiev, Michael Chorny, Ilia Fishbein, Boris Polyak, Darryl Williams
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics, Medical Devices, Diagnostics & Biosensors, Biomaterials & Drug Delivery
NOVEL GLUTAMATE TRANSPORTER ACTIVATORS AND METHODS USING SAME
PAGE TITLE Neuroprotective agent for Parkinson’s Disease PAGE SUMMARY Parkinson’s Disease (PD) is a progressive neurological disorder whose prevalence increases with age and certain genetic predispositions. It is estimated that 7-10 million people are affected by Parkinson’s Disease worldwide, with 1 million in the United States....
Published: 9/8/2025   |   Inventor(s): Sandhya Kortagere, Ole Mortensen, Andreia Mortensen, Joseph Salvino
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
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