PAGE TITLE
Overview
PAGE SUMMARY
Prof. Sandhya Kortagere of Drexel University has developed glutamate transport modulators for treating neurological disorders caused by glutamate dysregulation. These drugs increase clearance of the neurotransmitter glutamate by cells containing GLT-1, an important modulator of the glutamatergic system. Administration of these compounds can prevent and treat neurological disorders, including Parkinson’s, Alzheimer’s, Huntington’s disease, ALS, stroke, epilepsy and Schizophrenia, which are associated with excessive extracellular glutamate. These compounds target GLT-1 activity, aiming to regulate glutamate transmission and alleviate symptoms of various neurological conditions, without interfering with the neuronal glutamate receptors.
APPLICATIONS TITLE: Market Applications
Pharmaceutical therapy for neuropsychiatric disorders including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, ALS, stroke, epilepsy, and schizophrenia. Research and development in the areas of glutamate regulation and neurological disorders.
ADVANTAGES TITLE:Key Advantages
Targeted modulation of GLT-1 activity to regulate glutamate levels. Potential to prevent, treat, or ameliorate neurological disorders associated with glutamate dysregulation. Minimization of side effects as compared to traditional therapies targeting neuronal receptors.
Problem Solved TITLE:Problems Solved
Excessive extracellular glutamate concentrations are associated with many neuropsychiatric conditions. Limited efficacy and significant side effects of current small molecule therapies targeting neuronal receptors. Lack of treatments addressing the dysregulation of glutamate transporters like GLT-1.
IP STATUS
Intellectual Property and Commercialization Opportunities
Published PCT Application WO 2023/146831 A1
https://patents.google.com/patent/WO2023146831A1/en?oq=WO2023146831A1
Available for licensing, please contact our office for additional information
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Contact Information:
Ravi Raghani, Ph.D. Licensing Manager
Office of Applied Innovation
Drexel University
267-359-5525
rmr359@drexel.edu