Search Results - mei-hsiu+chen

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Exosome Gene Therapy for Treating Inner Ear Disease

Extracellular Vesicles Directly Target Inner Ear Cells to Correct Malfunctioning Genes In Vivo This in vivo gene therapy strategy combines selective gene editors with the cell targeting capability using extracellular vesicles for safe and targeted delivery., Hearing loss affects at least 1 in 500 newborns, and over 50% are hereditary in nature. One...

Published: 9/3/2024 | Inventor(s): Mei He, Xiaoshu Pan

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Human Health Care > Drug Delivery

Droplet-Based Electroporation for High-Throughput Biomolecular Cargo Loading of Extracellular Vesicles and Exosomes

Optimizes Cargo Loading a Sub-Cellular Scale, Enabling the Scaling of Drug Manufacturing This electroporation platform enables the efficient, large-scale loading of biomolecular cargo into extracellular vesicles (EVs) and exosomes. Extracellular vesicles (EVs) are biocompatible, have fast cellular uptake, and can penetrate biological barriers, making...

Published: 4/1/2024 | Inventor(s): Mei He

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Drug Delivery

Genomics-based Diagnostic Assay for Cancer

Abstract: Molecular profiling with high throughput assays has gained utility in the management of select cancer patients and several gene expression-based assays are now marketed for improved prognostic accuracy for patients with cancer. This technology describes a genomics based diagnostic assay for the diagnosis and prognosis of cancer patients. ...

Published: 4/8/2024 | Inventor(s): Steven Libutti, Mei He

Keywords(s): assay, CANCER, diagnostic, Genomics, PROGNOSIS

Category(s): Application > Diagnostics, TherapeuticArea > Oncology, Collaboration Sought > Licensing

Efficient and Scalable Cellular Production of Immune Functional Extracellular Vesicles

Utilizes Low-Power, Near-UV Light Induction to Produce Dendritic Cell-Derived Extracellular Vesicles for Use in Immunotherapy This simple, straightforward, and scalable production of dendritic cell-derived extracellular vesicles (DC-EVs) employs low-power, near-UV light. Dendritic cells are the most potent antigen-presenting cells and the key initiator...

Published: 7/24/2023 | Inventor(s): Mei He

Keywords(s):

Category(s): Technology Classifications > Human Health Care > Drug Delivery

Novel Multi-Omics Aging Clock

A multi-omics clock analyzes multiple layers of omics data with machine learning to predict remaining lifespan of mammals, particularly for animal model studies. Large omics data sets may be used from combinations of genomics, proteomics, lipids, etc. available from blood or other simple sample collection. This tool can robustly capture changes...

Published: 3/12/2024 | Inventor(s): George Sutphin, Samuel Freitas, Megha Padi, Chen Chen

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Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Screening assays, Technology Classifications > Research Tools > Simulators and Modeling Tools

Autonomous Drone for railroad track inspection

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than...

Published: 3/15/2023 | Inventor(s): Yu Qian, Yi Wang, Chen Chen

Keywords(s): autonomous drone, flight control, image processing, railroad track inspection, self-navigation

Category(s): Engineering and Physical Sciences

Aortic Valve Disease on a Chip

Valve-on-a-chip microfluidic device for study of calcific aortic valve disease pathophysiology and drug targets. Background: Calcific aortic valve disease (CAVD) is the most common valvular heart disease in the aging population of the developed world. CAVD is a condition in which calcium deposits form in the aortic valve of the heart, narrowing...

Published: 12/29/2023 | Inventor(s): Gretchen Mahler, Pong-Yu Huang, Bruce Murray, Mei-Hsiu Chen, Melissa Mendoza

Keywords(s): Technologies

Category(s): Campus > Binghamton University, Technology Classifications > Biomedical Science and Engineering

2015-671 Underground Shafts for Hydrogen Storage

SummaryResearchers at UCLA have developed an underground drilled shaft concept for storage of hydrogen or other gases.BackgroundOne challenge in creating a hydrogen economy is developing hydrogen gas storage solutions. Increased interest has helped the global hydrogen storage market grow to $2.6 billion in 2016, and it is expected to reach over $5...

Published: 7/19/2023 | Inventor(s): Adrienne Lavine, Hossein Kavehpour, Dante Simonetti, Richard Wirz, Chen Chen, Gabriela Bran, Gopinath Warrier, Hamarz Aryafar, Jonathon Kennedy, Joshua Jordan, Keith Lovegrove

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Generation > Solar, Energy & Environment > Energy Storage