Search Results - life+sciences+%3e+therapeutics+%3e+synthetic+biology

12 Results Sort By:
Controlled synthesis of poly(acetamidosaccharide) for sustainable and versatile materials
A new sustainable polymer, poly(acetamidosaccharide), is created through a simple two-step process. Serving as a sustainable cellulose acetate alternative, it mitigates microplastic pollution and offers customizable properties suitable for textiles, coatings, biotechnology, and food stabilization. Background Polymer science is integral to numerous...
Published: 3/3/2025   |   Inventor(s): Cassandra Callmann, Serena Joseph
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Therapeutics > Formulation
Efficient production and delivery of bioactive peptides via Gram-negative bacterial secretion system
Engineered Gram-negative bacteria use the microcin V secretion system to produce and release various active peptides efficiently. This versatile tech­nology works across multiple bacterial species and preserves peptide functionality for research and therapeutic uses. Background The production and secretion of bioactive peptides are critical in...
Published: 1/10/2025   |   Inventor(s): Bryan Davies, Sun-Young Kim, Jennifer Parker
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics > Synthetic biology
Biosynthesized halogenated tryptophan derivatives
A new E. coli-based system uses metabolic engineering and co-cultures to produce various halogenated tryptophan molecules from glucose, providing an environmentally friendly alternative for creating diverse compounds used in pharmaceuticals and other industries. Background Halogenated molecules are critical to various industries, including pharma­ceuticals,...
Published: 1/9/2025   |   Inventor(s): Hal Alper, Kevin Reed, Sierra Brooks
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Agriculture
pH-responsive hydrogel technology for enhanced oral delivery of therapeutic proteins
Improved hydrogel copolymers, made from itaconic acid and N-vinyl­pyrrolidone, enable oral delivery of therapeutic proteins by protecting them in the stomach and releasing them in the intestine. This enhances protein bioavailability and pharmacokinetics. Background Oral delivery of therapeutic proteins presents significant challenges due to the...
Published: 10/3/2024   |   Inventor(s): Nicholas Peppas, Michael Koetting
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Synthetic biology
Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
­This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery. Background The delivery of small...
Published: 9/6/2024   |   Inventor(s): Nicholas Peppas, William Liechty
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Biomaterials
Adaptive soft elastomeric material system with programmable functions inspired by venous valves
Programmable soft elastomeric materials, inspired by mammalian venous valves, alter their properties to perform life-like functions including motion, energy storage, logic operations, and signal filtering. Background Materials science and bioengineering aim to replicate the fundamental processes of living organisms through artificial material systems....
Published: 1/27/2025   |   Inventor(s): Wen Song, Thomas Underwood
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology
Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
Published: 7/11/2024   |   Inventor(s): Hal Alper, Kelly Markham, Claire Palmer
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Metabolic control over organometallic catalysts using electroactive bacteria
Background Dr. Benjamin Keith Keitz and his team have developed a new controlled polymerization methodology using an electroactive bacterium to synthesize responsive materials. Dr. Keitz is an Assistant Professor in the Department of Chemical Engineering at UT Austin. His primary research area focuses on using chemical and biological synthesis techniques...
Published: 6/10/2024   |   Inventor(s): Benjamin Keitz, Gang Fan, Chris Dundas, Austin Graham, Nathaniel Lynd
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology
Genetically encoded protein-based fluorescent biosensor for adenosine diphosphate ribose
Background Adenosine diphosphate ribose (ADPR) is a biologically important molecule that is known to regulate oxidative stress, calcium homeostasis, and mitochondrial function. Very little is known about ADPR signaling because it is a fast and transient process. Our innovation addresses this challenge by streamlining the development of fluorescent...
Published: 1/20/2025   |   Inventor(s): Xiaolu Cambronne, Shivansh Goyal
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Research tools > Tool/assay/screening platform
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024   |   Inventor(s): Wei Li, Hanyu Zhu, Vincent Wang
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
1 2