Search Results - life+sciences+%3e+therapeutics+%3e+formulation

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Thin-film freeze-dried antibiotic powders for fixed-dose pulmonary delivery
Background Pulmonary diseases such as nontuberculous mycobacterial infections and chronic obstructive pulmonary disease (COPD) remain major global health challenges, often requiring long-term antibiotic therapy delivered directly to the lungs to achieve effective pathogen clearance. Inhaled drug delivery provides a promising approach to increase local...
Published: 1/30/2026   |   Inventor(s): Zhengrong Cui, Reem Zaki, Michael Sandoval, Robert Williams, Jay Peters
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Sulfonyl-triazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease
Background Cellular metabolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neuro­degenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...
Published: 1/27/2026   |   Inventor(s): Ku-Lung Hsu, Xiaoding Jiang, Xiaolu Cambronne
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug discovery
Spray-dried RNA-lipid nanoparticle dry powder technology for stable and inhalable delivery of therapeutics
Background Messenger RNA (mRNA) therapeutics have rapidly emerged as a transformative method for vaccination and gene therapy. However, the field faces significant hurdles related to the instability of mRNA molecules, which are highly susceptible to enzymatic degradation. Lipid nanoparticles (LNPs) have become the delivery vehicle of choice, shielding...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Bhupendra Giri, Hugh Smyth
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Sulfonyl-purine probes for covalent targeting of lysine and tyrosine in drug discovery
Background A significant portion of the human proteome remains inaccessible to traditional drug discovery approaches, particularly proteins lacking reactive cysteines or well-defined binding pockets. These so-called “undruggable” targets present major challenges for small molecule therapeutics, limiting the development of treatments for...
Published: 1/13/2026   |   Inventor(s): Ku-Lung Hsu, Zhihong Li
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Research tools > Reagent
Dual-action topical formulations for enhanced skin penetration and targeted dermal repair
Background Dermatological and cosmetic treatments increasingly focus on targeted delivery of active compounds to the deeper skin layers to combat photoaging, oxidative damage, and carcino­genesis. However, the stratum corneum presents a formidable barrier to percutaneous absorption, limiting the efficacy of topically applied actives. Conventional...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Patricia Martins
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
High-dose dry powder inhaler for dual pulmonary and oral indomethacin delivery
Background Dry powder inhalers (DPIs) offer a non-invasive and rapid route for drug delivery, particularly for medications requiring swift systemic action. This is especially relevant for poorly soluble drugs such as indomethacin, where oral admini­stration is often limited by gastrointestinal degradation and adverse side effects. For indications...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Jamie Spahn, Feng Zhang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Inhalable vancomycin–DNase powder for eradication of MRSA lung infections
Background Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired pneumonia, contributing to elevated mortality, prolonged hospitalizations, and increased healthcare costs. The persistence of MRSA in the lungs is largely due to its ability to form biofilms and generate persister cells, both of which protect the bacteria...
Published: 1/13/2026   |   Inventor(s): Hugh Smyth, Rex Moore
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Irreversible DGKα inhibitors for enhanced T‑cell activation in cancer immunotherapy
Background Cancer immunotherapy seeks to harness the immune system to target and eliminate malignant cells. However, immune suppression within the tumor microenvironment poses a major challenge, blunting T-cell activation and allowing cancer cells to evade immune detection. Diacylglycerol Kinase α (DGKα) is a key enzyme that suppresses...
Published: 1/13/2026   |   Inventor(s): Ku-Lung Hsu, Minhaj Shaikh, Adam Libby, Surya Pravo Mookherjee
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Multilayered drug delivery implants for localized brain tumor therapy
Background As treatment strategies evolve for brain tumors, especially post-surgical resection, localized therapy is emerging as a promising alternative to systemic drug delivery. The blood-brain barrier, along with the sensitive anatomy of the brain, makes it difficult to achieve effective therapeutic concentrations using traditional methods without...
Published: 1/13/2026   |   Inventor(s): James McGinity, Feng Zhang, John Floyd, Michael McGinity
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 1/13/2026   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering
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