Search Results - life+sciences+%3e+therapeutics+%3e+formulation

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Small molecule compounds for REST degradation in glioblastoma cells
Scientists developed a new drug, GR-28, that inhibits a protein called SCP1. This leads to the degradation of another protein, REST, which promotes the growth of brain tumor cells. Combining GR-28 with a lipid metabolism inhibitor shows synergistic effects in killing tumor cells. Background Glioblastoma (GBM) is a highly aggressive and fatal brain...
Published: 10/22/2024   |   Inventor(s): Yan Jessie Zhang, Svetlana Panina, Dionicio Siegel
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Specialized storage technology for preserving axonal viability
A specialized calcium-free solution preserves peripheral nerve axons for up to nine days at low temperatures, enhancing nerve graft viability for effective repair of injuries using polyethylene glycol fusion, promoting rapid sensory and motor recovery. Background Peripheral nerve injuries (PNIs) often result in segmental-loss defects, leading to immediate...
Published: 10/21/2024   |   Inventor(s): George Bittner, David Jackson, Alexa Olivarez, Liwen Zhou, Cathy Yang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids
Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...
Published: 10/15/2024   |   Inventor(s): Hugh Smyth, Hairui Zhang, Robert Williams
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Multifunctional iron chelators to combat antibiotic resistance and enable bacterial imaging
Deferasirox derivatives, such as ExPh and ExBT, are designed to chelate iron and inhibit antibiotic-resistant bacteria like MRSA and VRE. They exhibit unique fluorescent properties for bacterial imaging, offering both therapeutic and diagnostic capabilities. Background Antibiotic resistance is a growing public health concern, driven by the rapid evolution...
Published: 10/14/2024   |   Inventor(s): Jonathan Sessler, Adam Sedgwick, James Brewster, II, Axel Steinbrück
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics
Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients
Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflamma­tion, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis. Background Chronic non-healing wounds, particularly...
Published: 10/4/2024   |   Inventor(s): Aaron Baker, Subhamoy Das
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Agriculture > Animal/veterinary
pH-sensitive hydrogel technology for enhanced oral delivery of high molecular weight therapeutic proteins
This invention describes a pH-sensitive hydrogel for oral delivery of therapeutic proteins like factor VIII or IX, used in hemophilia treatment. It protects proteins in the stomach and releases them in the intestine, enhancing bioavailability. Background Delivering therapeutic proteins orally presents significant challenges due to the body's natural...
Published: 10/3/2024   |   Inventor(s): Nicholas Peppas, Sarena Horava
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Polymeric tablet technology for controlled release of active agents
The invention describes a multi-layered polymer tablet designed for controlled release of active agents like pharma­ceuticals. Each layer contains specific polymers that respond to environmental triggers such as osmosis, solubility changes, or temperature variations to release the active agents in a controlled manner. Background The challenge...
Published: 9/27/2024   |   Inventor(s): Nicholas Peppas, Barbara Ekerdt, Marta Gomez-Burgaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Expression system for labeling and targeting cells with elevated calcium levels
The technology describes a system for labeling and targeting cells with elevated calcium levels, such as cancer cells or activated neurons, using a CREB reporter system. This system includes a synthetic CRE enhancer linked to promoters that control the expression of genes encoding functional proteins like reporters, ion channels, or therapeutic agents,...
Published: 9/16/2024   |   Inventor(s): Boris Zemelman
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Therapeutics > Formulation
Sustainable high molecular weight copolymers using the Vandenberg catalyst
This technology creates high molecular weight copolymers from lactones and epoxides using the Vandenberg catalyst. The process produces versatile, biodegradable materials with unique thermal properties and potential applications in environmental and biomedical fields. Background Copolymerization of lactones and epoxides is a crucial area of research...
Published: 9/13/2024   |   Inventor(s): Nathaniel Lynd, Malgorzata Chwatko
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Biomaterials
Targeting MELK with indolinone derivatives
A promising strategy for treating triple-negative breast cancer and glioblastoma Indolinone derivatives inhibit MELK, an enzyme linked to cancer cell cycle regulation, proliferation, and apoptosis. These inhibitors show promise in treating cancers like triple-negative breast cancer and glioblastoma by selectively targeting MELK, reducing cancer cell...
Published: 9/11/2024   |   Inventor(s): Kevin Dalby, Ramakrishna Edupuganti
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
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