Search Results - life+sciences+%3e+therapeutics+%3e+formulation

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Irreversible DGKα inhibitors for enhanced T‑cell activation in cancer immunotherapy
Background Cancer immunotherapy seeks to harness the immune system to target and eliminate malignant cells. However, immune suppression within the tumor microenvironment poses a major challenge, blunting T-cell activation and allowing cancer cells to evade immune detection. Diacylglycerol Kinase α (DGKα) is a key enzyme that suppresses...
Published: 7/31/2025   |   Inventor(s): Ku-Lung Hsu, Minhaj Shaikh, Adam Libby, Surya Pravo Mookherjee
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Multilayered drug delivery implants for localized brain tumor therapy
Background As treatment strategies evolve for brain tumors, especially post-surgical resection, localized therapy is emerging as a promising alternative to systemic drug delivery. The blood-brain barrier, along with the sensitive anatomy of the brain, makes it difficult to achieve effective therapeutic concentrations using traditional methods without...
Published: 7/1/2025   |   Inventor(s): James McGinity, Feng Zhang, John Floyd, Michael McGinity
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 6/16/2025   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering
SMART 3D-printed proliposomes for stable, targeted drug delivery
Background In the realm of drug delivery, particularly for cancer therapeutics, there is a growing demand for robust nanocarrier systems that offer improved targeting, extended shelf-life, and consistent efficacy. Liposomes have historically served as biocompatible delivery vehicles; however, they often suffer from formulation instability and limited...
Published: 5/27/2025   |   Inventor(s): Mohammed Maniruzzaman, Santosh Bashyal, Ishaan Duggal, Muhammad Rahim
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Controlled synthesis of poly(acetamidosaccharide) for sustainable and versatile materials
A new sustainable polymer, poly(acetamidosaccharide), is created through a simple two-step process. Serving as a sustainable cellulose acetate alternative, it mitigates microplastic pollution and offers customizable properties suitable for textiles, coatings, biotechnology, and food stabilization. Background Polymer science is integral to numerous...
Published: 7/2/2025   |   Inventor(s): Cassandra Callmann, Serena Joseph
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Therapeutics > Formulation
Small molecule compounds for REST degradation in glioblastoma cells
Scientists developed a new drug, GR-28, that inhibits a protein called SCP1. This leads to the degradation of another protein, REST, which promotes the growth of brain tumor cells. Combining GR-28 with a lipid metabolism inhibitor shows synergistic effects in killing tumor cells. Background Glioblastoma (GBM) is a highly aggressive and fatal brain...
Published: 10/22/2024   |   Inventor(s): Yan Jessie Zhang, Svetlana Panina, Dionicio Siegel
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Specialized storage technology for preserving axonal viability
A specialized calcium-free solution preserves peripheral nerve axons for up to nine days at low temperatures, enhancing nerve graft viability for effective repair of injuries using polyethylene glycol fusion, promoting rapid sensory and motor recovery. Background Peripheral nerve injuries (PNIs) often result in segmental-loss defects, leading to immediate...
Published: 6/27/2025   |   Inventor(s): George Bittner, David Jackson, Alexa Olivarez, Liwen Zhou, Cathy Yang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Advanced nanoparticle delivery system for targeted pulmonary administration of therapeutic nucleic acids
Lipid nanoparticles (LNPs) are designed for delivering RNA to lung tissues via inhalation. Composed of ionizable lipids, phospholipids, PEG-lipids, and cholesterol, they encapsulate RNA for therapeutic or immunological purposes, maintaining stability during nebulization. Background Gene therapy and editing hold significant promise for treating genetic...
Published: 10/15/2024   |   Inventor(s): Hugh Smyth, Hairui Zhang, Robert Williams
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Multifunctional iron chelators to combat antibiotic resistance and enable bacterial imaging
Deferasirox derivatives, such as ExPh and ExBT, are designed to chelate iron and inhibit antibiotic-resistant bacteria like MRSA and VRE. They exhibit unique fluorescent properties for bacterial imaging, offering both therapeutic and diagnostic capabilities. Background Antibiotic resistance is a growing public health concern, driven by the rapid evolution...
Published: 10/14/2024   |   Inventor(s): Jonathan Sessler, Adam Sedgwick, James Brewster, II, Axel Steinbrück
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics
Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients
Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflamma­tion, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis. Background Chronic non-healing wounds, particularly...
Published: 10/4/2024   |   Inventor(s): Aaron Baker, Subhamoy Das
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Agriculture > Animal/veterinary
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