Search Results - life+sciences+%3e+therapeutics+%3e+formulation

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Dual-action topical formulations for enhanced skin penetration and targeted dermal repair
Background Dermatological and cosmetic treatments increasingly focus on targeted delivery of active compounds to the deeper skin layers to combat photoaging, oxidative damage, and carcino­genesis. However, the stratum corneum presents a formidable barrier to percutaneous absorption, limiting the efficacy of topically applied actives. Conventional...
Published: 8/14/2025   |   Inventor(s): Hugh Smyth, Patricia Martins
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
High-dose dry powder inhaler for dual pulmonary and oral indomethacin delivery
Background Dry powder inhalers (DPIs) offer a non-invasive and rapid route for drug delivery, particularly for medications requiring swift systemic action. This is especially relevant for poorly soluble drugs such as indomethacin, where oral admini­stration is often limited by gastrointestinal degradation and adverse side effects. For indications...
Published: 8/14/2025   |   Inventor(s): Hugh Smyth, Jamie Spahn, Feng Zhang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug delivery
Inhalable vancomycin–DNase powder for eradication of MRSA lung infections
Background Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired pneumonia, contributing to elevated mortality, prolonged hospitalizations, and increased healthcare costs. The persistence of MRSA in the lungs is largely due to its ability to form biofilms and generate persister cells, both of which protect the bacteria...
Published: 8/14/2025   |   Inventor(s): Hugh Smyth, Rex Moore
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Irreversible DGKα inhibitors for enhanced T‑cell activation in cancer immunotherapy
Background Cancer immunotherapy seeks to harness the immune system to target and eliminate malignant cells. However, immune suppression within the tumor microenvironment poses a major challenge, blunting T-cell activation and allowing cancer cells to evade immune detection. Diacylglycerol Kinase α (DGKα) is a key enzyme that suppresses...
Published: 7/31/2025   |   Inventor(s): Ku-Lung Hsu, Minhaj Shaikh, Adam Libby, Surya Pravo Mookherjee
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Multilayered drug delivery implants for localized brain tumor therapy
Background As treatment strategies evolve for brain tumors, especially post-surgical resection, localized therapy is emerging as a promising alternative to systemic drug delivery. The blood-brain barrier, along with the sensitive anatomy of the brain, makes it difficult to achieve effective therapeutic concentrations using traditional methods without...
Published: 7/1/2025   |   Inventor(s): James McGinity, Feng Zhang, John Floyd, Michael McGinity
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Formulation
Engineered SGPL1 enzymes for selective extracellular S1P depletion in cancer immunotherapy
Background The sphingosine-1-phosphate (S1P) signaling axis plays a pivotal role in regulating immune cell trafficking, particularly in the context of cancer immunotherapy. S1P gradients between tumor-draining lymph nodes and the tumor micro­environ­ment govern lymphocyte migration, with elevated extracellular S1P concentrations leading to...
Published: 6/16/2025   |   Inventor(s): Everett Stone, Max Rodnick-Smith, Ranya Al-Khaledy, George Georgiou
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Metabolic engineering
SMART 3D-printed proliposomes for stable, targeted drug delivery
Background In the realm of drug delivery, particularly for cancer therapeutics, there is a growing demand for robust nanocarrier systems that offer improved targeting, extended shelf-life, and consistent efficacy. Liposomes have historically served as biocompatible delivery vehicles; however, they often suffer from formulation instability and limited...
Published: 5/27/2025   |   Inventor(s): Mohammed Maniruzzaman, Santosh Bashyal, Ishaan Duggal, Muhammad Rahim
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform, Life sciences > Therapeutics > Formulation
Controlled synthesis of poly(acetamidosaccharide) for sustainable and versatile materials
A new sustainable polymer, poly(acetamidosaccharide), is created through a simple two-step process. Serving as a sustainable cellulose acetate alternative, it mitigates microplastic pollution and offers customizable properties suitable for textiles, coatings, biotechnology, and food stabilization. Background Polymer science is integral to numerous...
Published: 7/2/2025   |   Inventor(s): Cassandra Callmann, Serena Joseph
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Therapeutics > Formulation
Small molecule compounds for REST degradation in glioblastoma cells
Scientists developed a new drug, GR-28, that inhibits a protein called SCP1. This leads to the degradation of another protein, REST, which promotes the growth of brain tumor cells. Combining GR-28 with a lipid metabolism inhibitor shows synergistic effects in killing tumor cells. Background Glioblastoma (GBM) is a highly aggressive and fatal brain...
Published: 10/22/2024   |   Inventor(s): Yan Jessie Zhang, Svetlana Panina, Dionicio Siegel
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
Specialized storage technology for preserving axonal viability
A specialized calcium-free solution preserves peripheral nerve axons for up to nine days at low temperatures, enhancing nerve graft viability for effective repair of injuries using polyethylene glycol fusion, promoting rapid sensory and motor recovery. Background Peripheral nerve injuries (PNIs) often result in segmental-loss defects, leading to immediate...
Published: 6/27/2025   |   Inventor(s): George Bittner, David Jackson, Alexa Olivarez, Liwen Zhou, Cathy Yang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation
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