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Biocompatible proteoliposome technology for enhanced wound healing and reduced inflammation in diabetic patients

Syndesomes—lipid vesicles with embedded syndecan-4 and PDGF-BB—enhance wound healing by promoting cellular activities, reducing inflammation, and improving tissue regeneration. They are particularly effective in diabetic and obese models, supporting re-epithelialization and angiogenesis. Background Chronic non-healing wounds, particularly...

Published: 10/4/2024 | Inventor(s): Aaron Baker, Subhamoy Das

Keywords(s):

Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Agriculture > Animal/veterinary

Pegylated aminoglycoside compounds for enhanced treatment of biofilm infections

Pegylated aminoglycoside compounds, like m-PEG-tobramycin, combine antibiotics with polyethylene glycol to enhance solubility, stability, and bioavailability, effectively penetrating and disrupting biofilm infections resistant to standard treatments. Background Biofilm-associated infections present a significant challenge in medical and industrial...

Published: 9/16/2024 | Inventor(s): Hugh Smyth, Ju Du

Keywords(s):

Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Agriculture > Animal/veterinary

Engineered polypeptides for enhanced integrin binding and antigen delivery

Engineered recombinant Invasin polypeptides have been modified to enhance integrin binding and resist intestinal proteolysis, facilitating effective oral delivery of therapeutics, such as vaccines, by targeting M cells in the gut for improved immune responses. Background The challenge of delivering therapeutics such as vaccines effectively across...

Published: 9/13/2024 | Inventor(s): Jennifer Maynard, Xianzhe Wang, Tarik Khan

Keywords(s):

Category(s): Life sciences > Therapeutics > Vaccines, Life sciences > Agriculture > Animal/veterinary, Life sciences > Therapeutics > Drug delivery

Improving the microbiome health of bees

Genetically engineered bacteria from the microbiome of bees are used to produce RNA interference (RNAi) molecules and other genetic tools to target and downregulate specific genes in bees or their pathogens. By reducing pathogen loads and altering gene expression of bees, this technology can combat threats to bee population, like colony collapse disorder,...

Published: 9/11/2024 | Inventor(s): Nancy Moran, Jeffrey Barrick, Sean Leonard

Keywords(s):

Category(s): Life sciences > Agriculture > Animal/veterinary, Life sciences > Therapeutics > Gene editing

Boosting bee health

A cocktail of native gut bacteria promotes health and pathogen resistance in bees Problem Honeybees and bumblebees play a crucial role in agricultural pollination, which is essential for human food production. Unfortunately, honeybee populations have experienced significant declines in the United States and around the world over the past decade. These...

Published: 8/15/2024 | Inventor(s): Nancy Moran, Sean Leonard, Waldan Kwong, Jenkyn Powell, Kasie Raymann

Keywords(s):

Category(s): Life sciences > Agriculture, Life sciences > Agriculture > Animal/veterinary

Low-cost fluorescent reporters for nuclease activity detection

Problem DNA cleavage or nuclease activity detection is important in many forms of nucleic acid amplification tests. The current detection technologies rely on the use of fluorescence resonance energy transfer (FRET) reporters that light up upon digestion, such as the Taqman® probe and the DNaseAlert®. Although these FRET reporters well serve...

Published: 6/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Soonwoo Hong, Yuan-I Chen, Yu-An Kuo, Trung Nguyen, Hsin-Chin Li

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Agriculture > Animal/veterinary