Search Results - genomics%2fepigenomics

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IL-13 Induced Gene Signature for Eosinophilic Esophagitis
IL-13 Induced Gene Signature for Eosinophilic Esophagitis (CHMC Ref. Id: 2007-0811) Overview: Eosinophilic esophagitis (EE) is an emerging worldwide disease. The current treatment for EE is with swallowed glucocorticoids, however, only a subset of EE patients experience remission from the disease following treatment with topical steroids. Dr....
Published: 8/20/2018   |   Inventor(s): Marc Rothenberg
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics
Lupus Nephritis Diagnostic Biomarker Panel
Four renal biomarkers: transferrin (TF), ceruloplasmin (Cp), lipocalin-type prostaglandin-D synthetase (L-PGDS), and alpha-1-acid glycoprotein (AGP), are capable of accurately diagnosing and determining the course of LN in both children and adults with systemic lupus erythematosis (SLE). While each individual biomarker can be used alone, the combination...
Published: 9/11/2022   |   Inventor(s): Prasad Devarajan, Hermine Brunner
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics
Category(s): Diagnostics
Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis
Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis (CHMC Ref. Id: 2007-0105) Overview: Several defects in neutrophil function have been noted in Crohn's Disease (CD), including reduced phagocytosis, adhesion, chemotaxis, and oxidative burst. This has been shown to reduce neutrophil accumulation at sites of injury, promoting...
Published: 10/31/2023   |   Inventor(s): Lee Denson, Bruce Trapnell, Kanji Uchida
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Protein Sci/Structural Bio/Medicinal Che, Systems Biology
Category(s): Diagnostics
Diagnostic and Prognostic for Crohn's Disease
Diagnostic and Prognostic for Crohn's Disease (CHMC Ref. Id: 2006-0202) Overview: Standard therapies for IBD include steroids and immunomodulators which lead to a sustained remission in approximately 50% of patients. Currently, there are no reliable predictors of response, leading Dr. Denson and colleagues to prepare and stratify patient...
Published: 2/8/2023   |   Inventor(s): Lee Denson, Bruce Aronow, Huan Xu
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Systems Biology
Category(s): Diagnostics
Expression Profile for Acute Childhood Asthma
Asthma is the most common chronic disease of childhood and has a strong genetic component. This technology identifies gene expression signatures that differentiate stable asthma and acute exacerbations. Researchers profiled gene expression patterns in nasal respiratory epithelial cells from children who had stable asthma, those experiencing asthma exacerbation,...
Published: 6/28/2022   |   Inventor(s): Gurjit Hershey, Bruce Aronow, Marsha Wills-Karp
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics
Category(s): Diagnostics
Diagnostic Classification of Esophagitis
Diagnostic Classificiation of Esophagitis (CHMC Ref. Id: 2005-0401) Overview: Eosinophilic esophagitis (EoE) is an emerging worldwide disease and growing health problem. The primary symptoms of EoE (chest and abdominal pain, dysphagia, heartburn, vomiting, and food impaction) are also observed in patients with chronic esophagitis (CE), including...
Published: 5/16/2024   |   Inventor(s): Marc Rothenberg
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics
Gene Chip to Diagnose Genetic Mutations Related to Liver Disease
Gene Chip to Diagnose Genetic Mutations Related to Liver Disease (CHMC Ref. Id: 2005-0306) Overview: There is a significant unmet need for a non-invasive means for accurate diagnosis, staging, and grading of liver diseases. Early diagnosis will help to elucidate the causes of these diseases and develop practical means of treatment and prevention....
Published: 8/20/2018   |   Inventor(s): Jorge Bezerra
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics
Category(s): Diagnostics
Critical Role for Eotaxin-3 in Eosinophilic Esophagitis
Critical Role for Eotaxin-3 in Eosinophilic Esophagitis (CHMC Ref. Id: 2004-1003) Overview: Eosinophilic esophagitis (EE) is often confused with gastroesophageal reflux disease (GERD), but it does not typically respond to anti-GERD therapy. Patients with EE typically have elevated levels of eosinophilis in their esophageal tissue and diagnosis...
Published: 5/16/2024   |   Inventor(s): Marc Rothenberg
Keywords(s): Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Therapeutics
Novel Genetic Marker for Food Allergy
Despite the similarities of food allergy with other atopic disorders, several characteristics of food allergy are distinct. Food allergy often presents very early in life and sometimes after only a single exposure to the allergen, making this technology attractive as a diagnostic for identifying at-risk infants at birth or soon thereafter.
Published: 5/3/2023   |   Inventor(s): Gurjit Hershey, Amal Assa'ad, Ranajit Chakraborty
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics
A Novel Genetic Marker for Asthma
A Novel Genetic Marker for Asthma (CHMC Ref. Id: 1998-0722) Overview: Asthma is a chronic inflammatory disorder that leads to increased airway responsiveness to a variety of stimuli and recurrent airway obstruction. Approximately 5% of adults and 7-10% of children in the U.S. have asthma. Asthma is the fourth leading cause of morbidity and the number...
Published: 8/20/2018   |   Inventor(s): Gurjit Hershey
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics
Category(s): Diagnostics