Gene Chip to Diagnose Genetic Mutations Related to Liver Disease

Gene Chip to Diagnose Genetic Mutations Related to Liver Disease

(CHMC Ref. Id: 2005-0306)

Overview:

There is a significant unmet need for a non-invasive means for accurate diagnosis, staging, and grading of liver diseases.  Early diagnosis will help to elucidate the causes of these diseases and develop practical means of treatment and prevention. Dr. Jorge Bezerra has assembled a diagnostic gene chip that can be used in early diagnosis of liver disorders.  Termed the "JAUNDICE CHIP", this technology is a re-sequencing chip that allows for full DNA sequencing of specifically identified genes involved in liver disease.  Furthermore, the detection of mutations wil be possible by hybridizing these chips with DNA isolated from blood samples from patients with liver disease.

Applications:

• Gene-based test for liver disease diagnosis and prognosis
• Liver disease research

Advantages:

• Rapid, accurate test
• Standardized diagnostic tool
• Early intervention and better disease management
• Potential for savings to healthcare system
• Simultaneously screen for mutations in the most common genes causing pathologic jaundice and other liver diseases

• Patent Issued 7,847,088
• Patent Applications Pending

Cincinnati Children's Lead Inventor:

Jorge Bezerra, M.D., Ph.D.