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Obesity-Induced Glucose Intolerance and Liver Fibrosis (UCLA Case No. 2021-323)
UCLA researchers in the School of En
g
ineering have discovered a novel method to treat obesity-induced glucose intolerance and liver fibrosis. BACKGROUND: The CDC reports that 41.9% of adults ages 20 and over are obese. An increased incidence of obesity also increases the rates of comorbidities such at type 2 diabetes mellitus (T2DM), non-alcoholic...
Published: 9/24/2024
|
Inventor(s):
Zhen
G
u
Keywords(s):
g
lucose intolerance
,
liver fibrosis
,
Nanoparticles
,
Notch si
g
naling pathway
,
obesity
Category(s):
Therapeutics > Metabolism And Endocrinolo
g
y
SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an inte
g
ral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024
|
Inventor(s):
Reece Akana
Keywords(s):
Cancer
,
Immuno-Oncolo
g
y
,
T-Cell Activation
Category(s):
Technolo
g
y Classifications > Biology
COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS Researchers at Stanford University have developed a novel therapeutic avenue for the treatment of osteoporosis and other musculoskeletal diseases. Musculoskeletal disease incidence rates have increased in recent years in response to an a
g
ing population. Available...
Published: 9/24/2024
|
Inventor(s):
Charles Chan
,
Thomas Ambrosi
,
Irvin
g
Weissman
,
Michael Lon
g
aker
,
Rahul Sinha
,
Debashis Sahoo
Keywords(s):
Hydro
g
el
,
Stem Cell
Category(s):
Technolo
g
y Classifications > Biology
DESI
G
N OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
DESI
G
N OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford University have developed novel universal vaccine candidates for H5 influenza viruses. Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to human...
Published: 9/24/2024
|
Inventor(s):
Duo Xu
,
Peter Kim
Keywords(s):
Immunofocusin
g
,
Vaccine
Category(s):
Technolo
g
y Classifications > Biology
NOVEL SMALL MOLECULE NE
G
ATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR
NOVEL SMALL MOLECULE NE
G
ATIVE ALLOSTERIC MODULATORS OF THE MU-OPIOD RECEPTOR Researchers at Stanford University and Washington University have discovered a novel molecular pathway for the treatment of opioid overdose. Opioids are a powerful tool for pain management when used in clinical care settings. However, in recent years these drugs have...
Published: 9/24/2024
|
Inventor(s):
Evan Obrien
,
Kaavya Kumar
,
Brian Kobilka
,
Susruta Majumdar
,
Vipin Ran
g
ari
Keywords(s):
Opiod
,
Pain
Category(s):
Technolo
g
y Classifications > Chemistry
C41 Analo
g
s
This invention relates
g
enerally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...
Published: 9/24/2024
|
Inventor(s):
Wei Wan
g
,
Rui Chan
g
,
Vijayan Ramachandran
,
Patrick Ronaldson
Keywords(s):
Category(s):
Technolo
g
y Classifications > Healthcare Portfolios > Neurology
,
Technolo
g
y Classifications > Life Sciences > Nutraceuticals
,
Technolo
g
y Classifications > Life Sciences > Small Molecules
,
Technolo
g
y Classifications > Life Sciences > Therapeutics
,
Technolo
g
y Classifications > Life Sciences > Biologics
Stimulation Device to treat Hand Weakness from Stroke or Spinal Injury
A
g
rowing number of people experience hand weakness due to stroke or spinal cord injuries. Electrical stimulation (e-stim) devices are commonly used to assist in hand weakness therapy. However, they are bulky, expensive, uncomfortable (may be ill-fitting, cause skin irritation or unpleasant sensation), and non-portable, eliminating the potential for...
Published: 9/24/2024
|
Inventor(s):
Atharva Wani
,
Niteesh Ni
g
am
,
Onkar Chavan
,
Yash Bellap
,
Joelly Lobato
,
Ishan Swanand Vyas
,
Suhrud Para
g
Joglekar
Keywords(s):
Category(s):
Life Science (All LS Techs)
,
Medical Devices
,
Manufacturin
g
/Construction/Mechanical
Vital Si
g
ns Monitoring using Depth Cameras
Cardiovascular disease is responsible for an estimated 17.9 million deaths each year, makin
g
it the leading cause of death worldwide. Continuous heart health monitoring way is the best preventative for heart failure. However, standard monitoring devices, including ECG and PPG, require direct physical contact, which can be difficult for certain patient...
Published: 9/24/2024
|
Inventor(s):
Yu Ron
g
,
Daniel Bliss
Keywords(s):
Category(s):
Computin
g
& Information Technology
,
Medical Devices
,
Life Science (All LS Techs)
,
Medical Dia
g
nostics/Sensors
,
Medical Ima
g
ing
Head Motion Correction with Soft Pressure Pad for MRI Scans
Addressed Need Head motion remains a major challen
g
e during medical imaging scans, particularly in pediatric and older patient populations. Motion impacts diagnostic image quality, costing both time and money in the clinical setting. In research, motion artifacts can introduce errors into quantitative measurements, especially in high-resolution or...
Published: 9/24/2024
|
Inventor(s):
Keywords(s):
Category(s):
Medical Devices
,
Medical Ima
g
ing
Inhibitors of the N-terminal Domain of the Andro
g
en Receptor (UCLA Case No. 2023-075)
Researchers at UCLA under the
g
uidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024
|
Inventor(s):
Matthew Retti
g
,
Michael Jun
g
Keywords(s):
andro
g
en receptor therapy
,
castration resistant prostate cancer
,
Oncolo
g
y
,
Oncolo
g
y (Small Molecules, Peptides and Antibodies)
,
prostate cancer
,
small molecules
Category(s):
Therapeutics > Oncolo
g
y
,
Therapeutics > Oncolo
g
y > Oncology (Small Molecules)
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