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ID
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A platform for mappin
g
reactive cysteines within the immunopeptidome
NU 2024-044 INVENTORS Xiaoyu Zhan
g
* Chenlu Zhang Chen Zhou SHORT DESCRIPTION This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome. BACKGROUND The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 10/31/2025
|
Inventor(s):
Keywords(s):
Category(s):
Life Sciences > Therapeutics
Method to Achieve Total Acoustic Transmission between Water and Air
A plane wave is incident from the water side of the asymmetric panel. The plates are separated by ribs set a distance 𝑑 apart with the intermediate space assumed to be air. Invention Summary: Effective sound transmission between water and air is challen
g
ing due to the vastly different acoustic impedances. Current methods are limited as they...
Published: 10/31/2025
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Inventor(s):
Andrew Norris
,
Hesam Bakhtiary Yekta
Keywords(s):
Category(s):
Technolo
g
y Classifications > Physical Sciences & Engineering
Acute Kidney Injury (AKI) Disrupts Cardiac Remodelin
g
via Serpin A3N
Advanta
g
es Novel Mechanistic Insight: Identification of SerpinA3N-GZMB axis links AKI to cardiac fibrosis and dysfunction. New Therapeutic Target: targeting SerpinA3N-GZMB axis enables a novel treatment approach for maladaptive cardiac remodeling. Diagnostic and Drug Discovery Potential: SerpinA3N and GZMB could serve as biomarkers for diagnostics...
Published: 10/31/2025
|
Inventor(s):
G
owda Pramod
,
Ruishen
g
Liu
Keywords(s):
Category(s):
Technolo
g
y Classifications > Medical
,
Technolo
g
y Classifications > Medical > Medical Diagnostics
,
Technolo
g
y Classifications > Medical > Pharmaceuticals
,
Technolo
g
y Classifications > Medical > Therapeutics
Scalable Ma
g
neto-Optical Trap and Gravimeter
(a) Side-view schematic of dual-MOT. (b) Mounted mirrors. (c) MOT mirror. (d) Incident laser beam. (e) Passin
g
through laser beam after the 1st mirror. (f) Passing-through laser beam after the 2nd mirror. Invention Summary: Cold-atom-sensors such as atomic gravimeters have been used in geological surveys and navigation. The complexities involved...
Published: 10/31/2025
|
Inventor(s):
Xuejian Wu
,
Timothy N
g
uyen
,
Mariam Mchedlidze
Keywords(s):
Category(s):
Technolo
g
y Classifications > Sensors
,
Technolo
g
y Classifications > Physical Sciences & Engineering
Scalable Ma
g
neto-Optical Trap and Gravimeter
(a) Side-view schematic of dual-MOT. (b) Mounted mirrors. (c) MOT mirror. (d) Incident laser beam. (e) Passin
g
through laser beam after the 1st mirror. (f) Passing-through laser beam after the 2nd mirror. Invention Summary: Cold-atom-sensors such as atomic gravimeters have been used in geological surveys and navigation. The complexities involved...
Published: 10/31/2025
|
Inventor(s):
Xuejian Wu
,
Timothy N
g
uyen
,
Mariam Mchedlidze
,
G
uanghui Su
Keywords(s):
Machines & Instruments
Category(s):
Technolo
g
y Classifications > Physical Sciences & Engineering
,
Technolo
g
y Classifications > Sensors
A Potent HIV Treatment with Low Toxicity
A small-molecule class that binds to HIV particles to improve immune response and block viral entry into cells. Problem: 37 million people worldwide currently live with HIV and an estimated 2-3 million new infections occur annually. While antiretroviral therapies do exist for those with the disease, therapy interruption leads to the re-emer
g
ence of...
Published: 10/30/2025
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Inventor(s):
Amos Smith
,
Xuchen Zhao
,
Tyler Hi
g
gins
,
Andres Finzi
,
Shilei Din
g
,
Daniel Lee
,
Marzena Paz
g
ier
,
Dun
g
Nguyen
,
William Tolbert
Keywords(s):
Dru
g
Target
,
HIV/AIDS
,
Small Molecule
,
Soft Materials
Category(s):
Technolo
g
y Classifications > Chemical Processes and Synthesis
,
Technolo
g
y Classifications > Therapeutics
Novel AKR1C3 Inhibitors in Cancer
Inhibitors and tools to block the local formation of steroid hormones in hormone-dependent mali
g
nancies of the prostate, breast and endometrium Value Proposition: Standard treatment of care for hormone-dependent tumors utilizes hormone ablative therapies. These agents non-discriminately block the action of estrogens and androgens and have untoward side...
Published: 10/30/2025
|
Inventor(s):
Trevor Pennin
g
,
Ade
g
oke Adeniji
,
Michael Byrns
,
Jeffrey Winkler
,
Barry Twenter
,
Lawrence Marnett
,
Andy Liedtke
Keywords(s):
Men's Health
,
Oncolo
g
y
,
Small Molecule
,
Women's Health
Category(s):
Technolo
g
y Classifications > Therapeutics
T Cells Tar
g
eting Misformed Proteins to Treat Neurodegenerative and Muscular Diseases
Anti
g
en-specific immunotherapy with engineered cytotoxic T cells targeting misformed proteins to treat neurodegenerative and muscular diseases. Problem: Neurodegenerative and muscular diseases, such as amyotrophic lateral sclerosis (ALS), inclusion body myositis (IBM), and Alzheimer’s disease (AD), collectively affect over 5 million adults...
Published: 10/30/2025
|
Inventor(s):
Nin
g
Jenny Jiang
,
Shahab Chizari
Keywords(s):
Bioen
g
ineering
,
Cell Therapy
,
Immunolo
g
y
,
Immunotherapy
,
Inflammation
,
Neurode
g
enerative Diseases
Category(s):
Technolo
g
y Classifications > Diagnostics
,
Technolo
g
y Classifications > Research Tools & Reagents
,
Technolo
g
y Classifications > Therapeutics
Seasonally-Adaptive Battery Thermal Mana
g
ement System for Electric Vehicles
Invention Description Electric vehicles are becomin
g
more common, especially with the push for greater utilization of renewable energy. However, it is widely known that electric vehicles suffer from safety issues associated with mistreatment, collisions, and charging issues. Further, batteries in electric vehicles often have performance degradation...
Published: 10/30/2025
|
Inventor(s):
Moustafa Amer
,
Mahmoud Shouman
,
Arunachala Kannan
,
Ahmed Hamed
,
Mohamed Salem
Keywords(s):
Category(s):
Physical Science
,
Advanced Materials/Nanotechnolo
g
y
,
Ener
g
y & Power
Thermal Performance Assessment and Mana
g
ement System for Lithium-Ion Batteries
Invention Description Technolo
g
ical breakthroughs in electric batteries have resulted in higher energy density batteries which have risks of overheating during high-rate charging and discharging. This leads to performance degradation, limiting battery lifespan and capacity and hindering widespread battery adoption. Battery management systems (BMSs)...
Published: 10/30/2025
|
Inventor(s):
Moustafa Amer
,
Mohamed Salem
,
Arunachala Kannan
,
Ahmed Hamed
,
Mahmoud Shouman
Keywords(s):
Category(s):
Advanced Materials/Nanotechnolo
g
y
,
Ener
g
y & Power
,
Physical Science
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