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Search Results - robert+mach
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PET Radiotracers for Diagnosis and Patient Stratification of Neurodegenerative Disorders
Small molecules that bind to alpha-synuclein deposition and can be used for PET imagining in patients with synucleinopathies Problem: Imaging alpha-synuclein (αS) using noninvasive techniques such as positron emission tomography (PET) can help with the early diagnosis of synucleinopathies. Previous PET radiotracers suffer from low binding affinity...
Published: 6/6/2024
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Inventor(s):
Robert Mach
,
E. James Petersson
Keywords(s):
Imaging Agents
,
Neurodegenerative Diseases
,
Radiology
,
Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Diagnostics
,
Technology Classifications > Imaging
,
Technology Classifications > Research Tools & Reagents
Improved PARP Inhibitors for Imaging and Treatment of Cancer and Neurodegenerative Diseases
Novel high-affinity PARP inhibitors with various properties for imagining and treating cancer and inflammation-related diseases Technology Overview: The poly(ADP-ribose) polymersase-1 (PARP-1) enzyme is heavily involved in propagating neurodegeneration and cancer. In neurodegeneration PARP-1 causes cell death, while in cancer PARP-1 acts as DNA...
Published: 1/10/2024
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Inventor(s):
Robert Mach
Keywords(s):
Category(s):
Technology Classifications > Imaging
,
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics