Search Results - dennis+drayna

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Genetic Mutations Associated with Stuttering
NIH investigators, for the first time, identified specific mutations associated with stuttering. These mutations are located within the genes encoding three enzymes, Glc-NAc phosphotransferase catalytic subunit [GNPTAB], Glc-NAc phosphotransferase recognition subunit [GNPTG], and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [NAGPA]....
Published: 7/25/2024   |   Inventor(s): Changsoo Kang, Dennis Drayna
Keywords(s): diagnostic, GNPTAB, GNPTG, IAXXXX, IB6XXX, IBXXXX, IXXXXX, NAGPA, Patent Category - Biotechnology, Stuttering, therapeutic, USES
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Application > Vaccines
Human Sweet and Umami Taste Receptor Variants
The complexity of taste discrimination (salty, sour, sweet, umami and bitter) varies between human individuals and populations. Sweet and umami (the taste of glutamate) tastes play a major role in the perception of calorically-rich and essential nutrients and there are well-documented differences in individual perception of sweet and umami flavorings,...
Published: 7/25/2024   |   Inventor(s): Un-kyung Kim, Dennis Drayna
Keywords(s): AC4XXX, ACXXXX, AXXXXX, GENOTYPES, Haplotypes, Human, ICXXXX, IXXXXX, population genetics, SNPs, sweet taste, TASTE, taste evaluation, taste receptors, umamai taste, VARIANTS
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Haplotypes of Human Bitter Taste Receptor Genes
Bitter taste has evolved in mammals as a crucial, important warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter, and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is very large and...
Published: 7/25/2024   |   Inventor(s): Un-kyung Kim, Dennis Drayna
Keywords(s): AC4XXX, ACXXXX, AXXXXX, Bitter, bitter taste, Chromosome 22 ring, flavor evaluation, Haplotypes, Human, ICXXXX, IXXXXX, population genetics, R 22, RECEPTOR, SNPs, TASTE, taste masking, taste receptors, VARIANTS
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, Application > Research Materials, Application > Diagnostics
Phenylthiocarbamide (PTC) Taste Receptor
Bitter taste has evolved in mammals as a central warning signal against ingestion of poisonous or toxic compounds. However, many beneficial compounds are also bitter and taste masking of bitter tasting pharmaceutical compounds is a billion dollar industry. The diversity of compounds that elicit bitter-taste sensations is vast and more than two dozen...
Published: 7/25/2024   |   Inventor(s): Un-kyung Kim, Dennis Drayna
Keywords(s): bitter taste, ICXXXX, IXXXXX, Phenylthiocarbamide, POLYMORPHISMS, PTC, RECEPTOR, SNPs, taste masking
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
A Water-Soluble Prodrug for the Heat Shock-Inducing Compound Withaferin A
University of Arizona researchers have developed an economically viable and environmentally friendly method for producing and isolating large quantities of both Withaferin A and the novel withanolides. Aeroponic cultivation is a significant achievement as acquiring an abundant supply of starting material is often a significant hurdle in the development...
Published: 4/3/2023   |   Inventor(s): Leslie Gunatilaka, Dennis Ray, Yaming Xu, Kithsiri Wijeratne
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics