Search Results - catherine+robinson

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SpdE, a Novel Amino Acid-sensing Diguanylate Cyclase
1. Technology Overview The invention introduces SpdE, a novel bacterial protein that senses specific amino acids (valine, proline, and isoleucine) at nanomolar concentrations. This highly sensitive protein offers significant potential for applications in clinical diagnostics, biotechnology, and industrial processes. The technology leverages established...
Published: 1/8/2026   |   Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson
Keywords(s): Science
Category(s): Diagnostics, Research Tools, Therapeutics
PSMA-Targeted CAR-T Therapy for Castration-Resistant Prostate Cancer
This invention includes ten novel PSMA-targeted CAR-T therapies to treat castration-resistant prostate cancer. The CAR-T constructs were generated using scFvs from five different mouse hybridomas. We have further enhanced the lead PSMA-targeted CAR-T therapy by co-expressing IRF4 to regulate effector T cell activity and tissue infiltration. The co-expression...
Published: 6/9/2025   |   Inventor(s): Bin He
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Cell and Gene Therapies, Clinical Area > Cancer, Research Area > Cancer