Search Results - catherine+robinson

2 Results Sort By:
SpdE, a novel amino acid-sensing diguanylate cyclase
SpdE, a novel amino acid-sensing diguanylate cyclase Tech ID UO-19-33 Animals are colonized by dynamic communities of bacteria, largely acquired by transmission from the external environment and other hosts; however, the traits that promote a microbe’s ability to be host-associated (i.e. to colonize or otherwise exist within a host) are not...
Published: 6/21/2024   |   Inventor(s): Karen Guillemin, Emily Sweeney, Catherine Robinson
Keywords(s): Science
Category(s): Diagnostics, Research Tools, Therapeutics
PSMA-Targeted CAR-T Therapy for Castration-Resistant Prostate Cancer
This invention includes ten novel PSMA-targeted CAR-T therapies to treat castration-resistant prostate cancer. The CAR-T constructs were generated using scFvs from five different mouse hybridomas. We have further enhanced the lead PSMA-targeted CAR-T therapy by co-expressing IRF4 to regulate effector T cell activity and tissue infiltration. The co-expression...
Published: 10/1/2024   |   Inventor(s): Bin He
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Cell and Gene Therapies, Clinical Area > Cancer, Research Area > Cancer