Search Results - carla+koehler

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Targeting TDP-43 for Parkinson's Disease Therapy
This invention is a molecule that targets the aberrant aggregation of a certain protein (TDP-43, associated with neurodegeneration) of neurons. The molecule binds to a specific site within the TDP-43 protein, and this helps prevent the unwanted aggregation of TDP-43 within neurons. The molecule has been shown to stop and even reverse neurodegeneration...
Published: 4/3/2023   |   Inventor(s): May Khanna, Liberty Francois-Moutal, Carla Koehler
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules
2018-022 SMALL MOLECULE MODULATORS THAT MEDIATE PINK1 AND PARKIN TRAFFICKING IN MITOCHONDRIA
UCLA researchers have developed two novel small molecule probes, MB-10 and DECA, that attenuate PINK1 and Parkin trafficking in mitochondrial in human cells that provide a new approach to elucidate the mechanisms of mitophagy.BACKGROUND:Mitophagy is an important pathway that selectively degrades dysfunctional mitochondria to keep the cell healthy. Neurodegenerative...
Published: 7/3/2025   |   Inventor(s): Carla Koehler
Keywords(s): Life Science Research Tools, Other Reagents
Category(s): Life Science Research Tools > Other Reagents
2009-221 Small Molecule Modulators of Mitochondrial Protein Import (MitoBloCK1)
Small Molecule Modulators Of Mitochondrial Protein ImportSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have discovered a set of small molecules that modulate the protein translocation across the mitochondrial membranes, which in turn controls the assembly and function of the mitochondria.BACKGROUNDMitochondria are rod-shaped...
Published: 7/17/2025   |   Inventor(s): Carla Koehler, Samuel Hasson
Keywords(s): Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)