Search Results - brian+o%27connell

4 Results Sort By:
Hybrid Adeno-Retroviral Vector for the Transformation of Cells (E-258-1998)
The invention described and claimed in this patent application provides for novel hybrid vectors which may be used for cell transformation, either in vivo or in vitro. The hybrid vectors have an adenoviral backbone with retroviral long terminal repeats (LTRs). Such vectors are capable of transforming dividing or non-dividing cells and integrate stably...
Published: 7/25/2024   |   Inventor(s): Bruce Baum, Brian O'connell, Changyu Zheng
Keywords(s): Adeno-Retroviral, Chimeric Vector, Duke DNA Project, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, hybrid vector, Vector, viral vector
Category(s): Application > Therapeutics
Hybrid Adeno-Retroviral Vector for the Transformation of Cells (E-312-2000)
The invention described and claimed in these patent applications provides for novel hybrid vectors which may be used for cell transformation either in vivo, in vitro, or ex vivo. The hybrid vectors, which are capable of integrating into the chromosome of the host cell and are capable of transducing dividing and non-dividing cells, have an adenoviral...
Published: 7/25/2024   |   Inventor(s): Changyu Zheng, Brian O'connell, Bruce Baum
Keywords(s): GB2AXX, GB2CXX, GBXXXX, GXXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics
Ultrastable Silver Nanoparticles
Project ID: D2014-05Background Silver nanoparticles have shown huge technological promise in wide variety of applications due to their superior optical properties, bioactivity, and diversity of chemical and photochemical properties. However, the main challenge with silver nanoparticle is its chemical instability to oxidation, i.e. tarnishing, which...
Published: 6/18/2024   |   Inventor(s): Terry Bigioni, Anil Desireddy, Brian Conn
Keywords(s): Clusters, Nanoparticles, Silver
Category(s): Materials, Manufacturing
MiRNAs as Novel Therapeutics and Non-invasive Biomarkers for Bone Metastasis
Princeton Docket # 12-2807 Researchers in the Molecular Biology Department at Princeton University have discovered a group of miRNAs as novel therapeutics for bone metastasis. Through a series of in vitro and in vivo experiments, five distinctive miRNAs have been identified as inhibitors of osteoclast differentiation. Further, systemic treatment...
Published: 3/30/2022   |   Inventor(s): Yibin Kang, Brian Ell
Keywords(s): biomarker/diagnostic, Biotechnology/Pharmaceuticals, cancer/oncology, drug discovery, miRNA, therapeutic
Category(s): Biotechnology/Pharmaceuticals, Medical Devices/Diagnostics