Search Results - angelina+anani

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Digital Twin for Geomechanical Safety Monitoring
This technology is a 3D digital twin of rock mass used by mining experts and companies to monitor rock mass conditions to ultimately enhance mine safety. This comprehensive framework incorporates various geotechnical parameters, scanning technologies, and data acquisition systems to manage, analyze, and interpret the data to generate up-to-date 3D visualizations...
Published: 9/3/2024   |   Inventor(s): Nilufer Blanche Akbulut, Angelina Anani, Leonard Brown
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Industrial & Manufacturing > Mining, Technology Classifications > Software & Information Technology > Databases & Data Mining
Computer Vision Method for Safety Hazards Detection, Referencing, and Tracking
This invention is a method for automatic identification and real-time mapping of safety hazards and individuals within underground spaces, such as mines. Using a combination of visual, Near-Infrared (NIR), and LiDAR imaging technologies with a robust, low-cost, machine learning-based algorithm, this innovation captures data and geo-references and categorizes...
Published: 8/1/2024   |   Inventor(s): Maria Nathalie Risso, Angelina Anani, Pedro Lopez-Vidaurre
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Industrial & Manufacturing > Mining, Technology Classifications > Imaging & Optics > Sensors and Detection > Inspection, Technology Classifications > Software & Information Technology
Clonal Spodoptera Frugiperda Cell lines for Enhanced Expression
This technology includes Spodoptera frugiperda (Sf9) cells which were developed to produce recombinant adeno-associated virus. The cells maintain a copy of the vector genome and for production, require infection with a single baculovirus that expresses either structural and nonstructural proteins to produce rAAV, or the non-structural (Rep) proteins...
Published: 8/12/2024   |   Inventor(s): Lina Li, Robert Kotin
Keywords(s):  
Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Plasmids/Vectors
Coherent Generation Of High-Dimensional Structured Light Using A Hyperdimensional Spin-Orbit Microlaser
The current invention describes next-generation high-capacity noise-resilient communication and computing technology. The invention describes a method to coherently generate high-dimensional structured light, including spin-orbit states, in an integrated and scalable way. Problem: On-chip information technologies are mostly limited to two-level systems...
Published: 10/16/2023   |   Inventor(s): Liang Feng, Zhifeng Zhang, Haoqi Zhao, Li Ge
Keywords(s): Augmented Reality (AR) & Virtual Reality (VR), Optics & Photonics 
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Materials, Technology Classifications > Imaging
High Affinity Cross Species Single Domain Antibodies Targeting Mesothelin
Abstract: Mesothelin is a cell surface protein that is an excellent target for immunotherapy because of its limited expression on normal tissues and its high expression on many cancers, including mesothelioma, cholangiocarcinoma, pancreatic, ovarian, lung, stomach, bile duct, and triple-negative breast cancer. Researchers at the National Cancer Institute’s...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Ira Pastan, Jessica Hong, Nan Li
Keywords(s): ADC, Antibody-drug Conjugate, Bispecific Antibody, CAR, chimeric antigen receptor, HO, MESOTHELIN, Mesothelioma, Recombinant Immunotoxins, RITs
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Anti-Glypican 2 Chimeric Antigen Receptor (CAR) Containing CD28 Hinge And Transmembrane Domains For Treating Neuroblastoma
Abstract: Neuroblastomas are the most common extracranial solid tumors in pediatric patients, with 700-800 new cases annually in the United States. Metastatic neuroblastomas have a five-year survival rate of 50% and account for 15% of all pediatric cancer deaths. As such, more effective treatments against high-risk neuroblastomas are urgently needed....
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Carol Thiele Galetto, Nan Li, Rosa Nguyen, Rosandra Kaplan
Keywords(s): CAR, chimeric antigen receptor, Glypican 2, GPC2, HO, Immunotherapy, Medulloblastoma, Neuroblastoma, Retinoblastoma, Small-Cell Lung Cancers
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Human Monoclonal Antibodies Targeting Glypican-2 in Neuroblastoma
Abstract: Neuroblastoma is a rare pediatric cancer that affects one in every hundred thousand children under the age of fifteen in the United States. Current standards of care  are chemotherapy and surgery, followed by stem-cell treatments, radiation and anti-ganglioside antibody therapy, which yield an average three-year survival rate of 10-45%. This...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Dimiter Dimitrov
Keywords(s): ADC, ANTIBODY, Antibody-drug Conjugate, Bispecific Antibody, CAR, chimeric antigen receptor, Glypican-2, GPC2, Immunotoxin, Neuroblastoma, Recombinant Immunotoxin, Rit
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
High Affinity Monoclonal Antibodies Targeting Glypican-2 for Treating Childhood Cancers
Abstract: Neuroblastoma is a rare pediatric cancer with approximately 1,000 new cases arising annually. Current therapies have a less than forty-five percent (45%), three-year survival rate which demonstrate a need for a more effective treatment against this disease. Glypican-2 (GPC2) is a cell surface protein that is preferentially expressed in pediatric...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Bryan Fleming
Keywords(s): ADC, Antibody-drug Conjugate, CAR, chimeric antigen receptor, Glypican 2, GPC2, HO, Immunotoxin, Medulloblastoma, Neuroblastoma, Recombinant Immunotoxin, Retinoblastoma, Rit
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
New Chimeric Antigen Receptor (CAR) Format for Developing Improved Adoptive Cell Therapies
Abstract: Adoptive cell therapy (ACT) is an attractive new therapeutic approach for treating various cancers. ACT has recently demonstrated a high degree of efficacy when treating patients with hematological malignancies. However, to date, no effective Chimeric Antigen Receptors (CAR) T cell therapy exists for solid tumors. Researchers in the National...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Dan Li
Keywords(s): CANCER, chimeric antigen receptor (CAR), GPC2, GPC3, HO, MESOTHELIN, solid tumor, tumor antigen
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
High Affinity Monoclonal Antibodies Targeting Glypican-1
Abstract: Pancreatic cancer is the fourth most common cause of death from cancer in the U.S. The overall 5-year survival rate for this disease is 8.5%. Glypican-1 (GPC1), a cell surface heparan sulfate proteoglycan protein that is overexpressed in pancreatic cancer. Due to this preferential expression, GPC1 represents a potential candidate for targeted...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li
Keywords(s): ADC, Antibody-drug Conjugate, Bispecific Antibody, CAR, chimeric antigen receptor, Glypican-1, GPC1, HO, Immunotoxin, NANOBODY, Pancreatic Cancer, Recombinant Immunotoxin, Rit, Single Domain Antibody
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
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