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Blood loss and infections are a major cause of concern and death for traumatic injuries and wounds. It is estimated that blood loss accounts for more than 35% of all prehospital deaths in trauma patients. Thus, it is imperative that bleeding is stopped quickly and at the point of care. While there are many products to staunch bleeding, including gauze...

Published: 1/8/2025 | Inventor(s): Emily Byrne, Grace Billingsley, Tran Nguyen, Alfonso Gomez-De Leon, Oscar Voeller, Sarah Stabenfeldt, Jessica Weaver

Keywords(s):

Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Devices

Selective Modulators of Ah-R to Treat Cancer

Synergistic compositions and method of using modulators of Ah-R activity and synergistic compounds to treat cancer Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. When activated by the binding of a wide range of both endogenous and exogenous small molecules, AhR signaling influences cellular outcomes in different...

Published: 1/8/2025 | Inventor(s): Siva Kolluri, Bach Nguyen, Daniel Elson

Keywords(s):

Category(s): Therapeutics

A Dynamic and Adaptive Approach for Resolving Motion (Case No. 2024-250)

Summary: UCLA researchers in the Department of Radiology have developed a novel method to capture time-varying and irregular cardiac motion, producing high-precision, high-quality cine images. Background: Cine MRI is a specialized imaging technique that captures motion through a series of images, often used to evaluate cardiac function and morphology....

Published: 12/20/2024 | Inventor(s): Zhengyang Ming, Dan Ruan, Anthony Christodoulou, Kim-Lien Nguyen

Keywords(s): arrhythmia, Biomonitoring, Cardiac Magnetic Resonance Imaging, cardiovascular diseases, cardiovascular monitoring, Image Resolution, Imaging, Magnetic Resonance Imaging, Medical Device, medical device cardiac monitoring, Medical Imaging, Monitoring And Recording Systems, MRI, non-invasive cardiac monitoring, optimization

Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Medical Devices > Monitoring And Recording Systems

Enhanced S10-3 Cell Line for Advanced Hepatitis E Virus Research and Therapeutic Development

The Huh-7 cell line underwent a detailed sub-cloning process to enhance its effectiveness for Hepatitis E Virus (HEV) infection studies. This involved diluting and culturing cells in 96-well plates until confluent monolayers formed, followed by selection and expansion of the most suitable cells. The sub-clone S10-3, derived from this process, was identified...

Published: 12/10/2024 | Inventor(s): Suzanne Emerson, Hanh Nguyen, Udana Torian

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease

Enhanced fluorescence via DNA aptamer optimization

This invention improves the fluorescence of DNA-based aptamers by substituting the original fluorophore with TO1-biotin and identifying a critical mutation that further enhances fluorescence. Background Fluorogenic DNA aptamers (FAPs) are a crucial tool in molecular biology, particularly for applications like live-cell imaging and highly specific...

Published: 12/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

Enhanced fluorescence via DNA aptamer optimization

Published: 12/6/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Yuan-I Chen, Yu-An Kuo, Yujie He, Trung Nguyen, Soonwoo Hong, Anh-Thu Nguyen, Sohyun Kim, Saeed Seifi

Keywords(s):

Category(s): Life sciences > Research tools > Tool/assay/screening platform

Tixocortol for the Prevention or Treatment of SARS-CoV-2 and Other Coronaviruses

Summary: The National Cancer Institute (NCI) seeks collaborators and/or licensees for co-development and commercialization of an inhibitor of coronavirus main protease. Description of Technology: The recent COVID-19 pandemic led to millions of deaths worldwide – presenting an urgent need to develop vaccines and therapeutics against SARS-CoV-2...

Published: 12/20/2024 | Inventor(s): David Davis, Robert Yarchoan, Brett Eaton, Richard Gussio, Brian Peyser, Tam Nguyen, Ashwin Nair, Yana Astter

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Collaboration Sought > Licensing

Organ-on-Chip Apparatus for Quantitative Study of Cellular Interaction with Ultrasound

This is an organ-to-chip device that is constructed by using thin membranes. The device allows quantitative in vitro modeling of cellular interactions by using ultrasound. The technology also has a large potential for therapeutic applications for treating different diseases. The flexibility of organ-on-chip technologies is a great tool to help speed...

Published: 11/6/2024 | Inventor(s): Jian Gu, Adam Akkad, Frederic Zenhausern

Keywords(s):

Category(s): Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences

Unsupervised Region-Growing Network for Object Segmentation in Atmospheric Turbulence

Background Foreground and background segmentation is an important part of computer vision tasks including surveillance, remote sensing, and environmental monitoring. However, in long-range imaging for outdoor environments, substantial image distortions can occur due to atmospheric turbulence. These distortions limit the effectiveness of segmentation...

Published: 11/4/2024 | Inventor(s): Dehao Qin, Ripon Kumar Saha, Suren Jayasuriya, Jinwei Ye, Nianyi Li

Keywords(s):

Category(s): Physical Science, Imaging, Applied Technologies, Environmental

Fluorescence lifetime imaging for retinal function assessment

This invention uses a laser-based imaging system to study the eye’s retina. By measuring light responses, it provides insights into retinal health and potential diseases like age-related macular degeneration. Background Two-photon excited fluorescence (TPEF) is a powerful technique used to study the eye. TPEF allows researchers to excite intrinsic...

Published: 10/24/2024 | Inventor(s): Hsin-Chih (Tim) Yeh, Trung Nguyen, Yuan-I Chen, H. Grady Rylander, Yu-An Kuo, Soonwoo Hong, Anh-Thu Nguyen, Yujie He

Keywords(s):

Category(s): Life sciences > Imaging, Life sciences > Imaging > Microscopy

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