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First in class Small Molecule Agonists of the mammalian Relaxin family receptor 1 (RXFP1) and use in treatment of cancer, fibrotic, and vascular disorders (HHS Ref No. E-145-2024-0-US-02)
It is well documented in literature that activation of RXFP1 by relaxin induces: 1) up-regulation of the endothelin system which leads to vasodilation; 2) extracellular matrix remodeling through regulation of collagen deposition, cell invasiveness, proliferation, and overall tissue homeostasis; 3) a moderation of inflammation by reducing levels of inflammatory...
Published: 5/30/2025   |   Inventor(s): Juan Marugan, Mark Henderson, Kenneth Wilson, Wenwei Huang, Wenjuan Ye, Noel Southall, Jiankang Jiang, Khalida Shamim, Bing Li, Alexander Agoulnik, Abhijeet Kapoor, Joshua Hutcheson, Ana Cabrera, Irina Agoulnik
Keywords(s):  
Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Pulmonology, TherapeuticArea > Dermatology, TherapeuticArea > Reproductive Health, TherapeuticArea > Geriatrics
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Development of an Innovative AI-Enhanced Music-Based Magnetic Respiratory Therapy System
Advantages Uses magnetic sensors to monitor breathing without wires or chest straps AI adapts music in real time to regulate and stabilize respiration Designed for stress relief, respiratory therapy, and sleep quality improvement Comfortable, low-cost, and easy to use for home or clinical settings Summary Patients with respiratory issues whether...
Published: 5/20/2025   |   Inventor(s): Manh-Huong Phan, Dang Nguyen, Kee Young Hwang
Keywords(s): Therapeutics
Category(s): Technology Classifications > Medical > Therapeutics
Auto Hoist Stabilization System with Wireless Sync
THE CHALLENGE Modern helicopter rescue operations require hoist operations that are safe, fast, and stable—particularly when suspended payloads swing dangerously due to wind, rotor wash, or sudden movements. These swings not only pose serious safety risks but also slow down mission times and increase stress on crews. Existing systems often rely...
Published: 5/14/2025   |   Inventor(s): David Reineke, Kyle Nguyen, Luyi Tang, Walter Lacarbonara, Mary Lanzerotti, Rui Peng
Keywords(s):  
Category(s): Technology Classifications > Engineering, Technology Classifications > Architecture/Building, Technology Classifications > Mining and Recycling, Technology Classifications > Electronics
MDCare: AI-Based Real-Time Surgical Blood Loss Quantification System
Advantages Real-time and continuous blood loss estimation Automated and objective, minimizing human error Enhances surgical decision-making Seamlessly integrates into clinical workflows Mobile alerts for timely, remote monitoring Summary Inaccurate blood loss estimation during surgery remains a critical challenge, with traditional visual and...
Published: 5/12/2025   |   Inventor(s): Phat Huynh, Dang Nguyen, Trung Le, Aaron Muncey, Heath Rutledge-Jukes, Pallavi Jonnalagadda, Sammer Marzouk, Tram Le
Keywords(s): Artificial Intelligence, Medical Diagnostics, Sensors
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Sensors, Technology Classifications > Medical > Surgery, Technology Classifications > Data/AI > D/AI Imaging
Smart IoT System for Longitudinal Real-time Physiological Monitoring of Cancer Patients Undergoing Treatment
Advantages Provides continuous, real-time patient monitoring from home Uses compact, low-cost IoT devices designed specifically for sleep monitoring in cancer patients Enables predictive analysis of sleep apnea using machine learning and longitudinal data Improves comfort and accessibility over traditional in-lab sleep studies Summary Cancer...
Published: 5/9/2025   |   Inventor(s): Trung Le, Quoc Nguyen
Keywords(s): Artificial Intelligence, Wearable Monitoring Equipment
Category(s): Technology Classifications > Medical > Medical Devices
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025   |   Inventor(s): Libin Ye, Xudong Wang
Keywords(s): Drug Delivery and Nanomedicine, Drug Discovery
Category(s): Technology Classifications, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology
Method for Non-invasive Assessment of Pressure and Cardiac Efficiency (Case No. 2024-258)
Summary: Researchers in the Department of Medicine and Radiological Sciences at UCLA have developed a novel computational model for estimating ventricular mechanical efficiency using routine clinical exam practices. Background: Congenital heart disease (CHD) involves complex heart defects that make it harder for the heart to pump blood effectively....
Published: 4/22/2025   |   Inventor(s): Kim-Lien Nguyen, Sanjib Gurung, John Finn
Keywords(s): acute myocardial infarction, Blood Pressure, Catheterization, heart disease mitigation, heart failure, heart support, hemodynamic monitoring, ventricular system
Category(s): Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems, Therapeutics > Inflammation And Inflammatory Diseases, Medical Devices > Medical Imaging, Software & Algorithms > Bioinformatics
Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding
Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding Princeton Docket # 19-3543-1 Reed-Muller (RM) codes are among the oldest families of error-correcting codes. Compared to polar codes, RM codes have the advantage of having a simple and universal code construction, though RM codes do not yet possess...
Published: 4/10/2025   |   Inventor(s): Min Ye, Emmanuel Abbe
Keywords(s):  
Category(s): Computer Science and Information Technology
An Adaptive Approach for Synthetic Microvascular Network Generation (Case No. 2024-259)
Summary: UCLA researchers from the Department of Medicine have developed a method for synthetic microvascular network generation for improved coronary disease monitoring. Background: Synthetic microvascular network modeling can be used in diagnosing and managing microvascular diseases such as coronary microvascular disease (CMD). CMD is traditionally...
Published: 5/16/2025   |   Inventor(s): Kim-Lien Nguyen, Mostafa Mahmoudi, Amirhosseini Arzani
Keywords(s):  
Category(s): Medical Devices, Medical Devices > Cardiac, Medical Devices > Hospital Systems, Medical Devices > Medical Imaging, Medical Devices > Monitoring And Recording Systems, Software & Algorithms, Software & Algorithms > Digital Health
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