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Dual-target antibody toolkit for overcoming resistance in anti-angiogenic cancer therapy

Background Angiogenesis is a fundamental process in cancer progression, enabling tumors to grow and metastasize by forming new blood vessels. Vascular endothelial growth factor A (VEGFA) is a central driver of this process and a primary target for existing anti-angiogenic therapies. However, clinical resistance often develops through the compensatory...

Published: 1/27/2026 | Inventor(s): Jennifer Maynard, Samuel Blackman, Ahlam Qerqez, Nicole Johnson, Annalee Nguyen, Alison Lee

Keywords(s):

Category(s): Life sciences > Immunology, Life sciences > Research tools > Reagent

Reagent Molding Process for Point of Care Microfluidic Applications

Invention Description Lyophilization is a critical process for stabilizing reagents in point-of-care (POC) diagnostics, effectively eliminating the need for cold chain storage and preventing liquid evaporation. While this technology is essential for developing robust field-deployable devices, current industry standards are limited to producing reagents...

Published: 1/26/2026 | Inventor(s): Jennifer Blain Christen, Vi Nguyen

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Point of Care

User-Actuated Valve Actuator for Microfluidic Devices

Invention Description Lab-on-a-chip technology and microfluidic diagnostic devices often rely on complex mechanical or electrical systems to manipulate fluid, making them costly and bulky. These components may limit portability, decrease operational lifetime, and prevent widespread use by untrained personnel or patients at the point of care or at home....

Published: 1/12/2026 | Inventor(s): Clifford Anderson, Vi Nguyen, Jennifer Blain Christen

Keywords(s): Analytical Devices, Bioassay, Biosensor, Fluid, Micro-Fluidics

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices, Life Science (All LS Techs), Point of Care

High Resolution 3D Imaging of Diamonds with Multiphoton Microscopy

This invention describes a method of using multiphoton microscopy (MPM) for 3-dimensional imaging and spectral analysis of natural and synthetic diamonds, as well as diamond-like simulants. This non-destructive approach provides insights into the interior structure, fluorescent defects, and formation conditions of diamonds. This method can be used to...

Published: 1/6/2026 | Inventor(s): Khanh Kieu, Elana Alevy, Sam Crossley, Lam Nguyen, Phai Vu

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry, Technology Classifications > Imaging & Optics > Sensors and Detection > Inspection

Integrated Microfluid Cartridge for POC Biofluid Diagnostics

Invention Description Rapid and reliable nucleic acid assays are critical for diagnosing infectious diseases at the point of need, yet most systems rely on complex, expensive instrumentation and trained personnel. These requirements limit access to timely diagnostics in low-resource, remote, or decentralized settings. Many platforms typically require...

Published: 1/6/2026 | Inventor(s): Vi Nguyen, Clifford Anderson, Jennifer Blain Christen

Keywords(s):

Category(s): Applied Technologies, Bioanalytical Assays, Chemistries & Devices, Coronavirus, COVID-19, Diagnostic Assays/Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors, Point of Care, SARS-CoV-2

Phenotyping Single Ventricle Physiology Using Electronic Health Records (Case Nos. 2025-322 and 2025-323)

Summary: UCLA researchers have created a cutting-edge, automated phenotyping tool that harnesses electronic health records to enable rapid and precise identification of single ventricle physiology (SVP), especially in neonatal and pediatric populations. Background: Single ventricle physiology (SVP) is a rare heart condition that develops before birth...

Published: 1/6/2026 | Inventor(s): Kim-Lien Nguyen, William Hsu, Hang Xu

Keywords(s): Algorithm, cardiac cycle, Cardiovascular, Cardiovascular Disease, cardiovascular diseases, cardiovascular monitoring, cardiovascular prediction, Computer-Aided Diagnosis, heart disease mitigation, heart support, medical automation technology, Medical Device, medical device cardiac monitoring, Medical diagnostics, Medical Guideline, non-invasive cardiac monitoring, Smart medical device, Software, Software & Algorithms, Software Development Tools

Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems

A New Method for Dual Detection of Magnetic and Dielectric Signals from Core/Shell Nanoparticles for Advanced Biodetection and Diagnostics

Advantages Simultaneously detects magnetic and dielectric signals from core/shell nanoparticles with high sensitivity. Provides rapid, real-time biodetection in microfluidic systems using minimal sample volumes. Accurately differentiates healthy and cancer cells through enhanced signal responsiveness. Easily integrates into scalable biomedical...

Published: 12/1/2025 | Inventor(s): Manh-Huong Phan, Kee Young Hwang, T. Lee, Minh Nguyen, Supawitch Hoijang, Dakota Brown

Keywords(s): Biomarker, Nanotechnology, Sensors

Category(s): Technology Classifications > Electronics > Nanotechnology

Method and Apparatus for Improving the Signal-To-Noise Ratio in Multi-Dimensional Magnetic Resonance Imaging Data (Case No. 2025-204)

Summary: UCLA researchers have developed a software-based denoising method that makes cardiac MRI images clearer and more reliable, enabling more accurate heart function measurements without requiring longer scan times. Background: Cardiac MRI is a powerful imaging tool for assessing heart health because it can provide detailed pictures of how the...

Published: 11/13/2025 | Inventor(s): Xiaodong Zhong, Shu-Fu Shih, Holden Wu, Kim-Lien Nguyen

Category(s): Medical Devices > Cardiac, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Software & Algorithms > Image Processing, Software & Algorithms

Multiomic Approaches to Pediatric Inflammatory Bowel Disease

Invention Description Pediatric Inflammatory Bowel Disease (IBD), encompassing Crohn’s Disease and Ulcerative Colitis, presents significant clinical challenges due to its complex and heterogeneous nature, often leading to lifelong health complications. Current diagnostic and therapeutic strategies are limited by an incomplete understanding of...

Published: 1/17/2026 | Inventor(s): Todd Sandrin, Peter Jurutka, Haiwei Gu, Brad Pasternak

Keywords(s):

Category(s): Applied Technologies, Diagnostic Assays/Devices, Life Science (All LS Techs), Pharmaceuticals, Proteomic Assays/Reagents/Tools, Artificial Intelligence/Machine Learning

Scalable Magneto-Optical Trap and Gravimeter

(a) Side-view schematic of dual-MOT. (b) Mounted mirrors. (c) MOT mirror. (d) Incident laser beam. (e) Passing through laser beam after the 1st mirror. (f) Passing-through laser beam after the 2nd mirror. Invention Summary: Cold-atom-sensors such as atomic gravimeters have been used in geological surveys and navigation. The complexities involved...

Published: 10/31/2025 | Inventor(s): Xuejian Wu, Timothy Nguyen, Mariam Mchedlidze

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Category(s): Technology Classifications > Sensors, Technology Classifications > Physical Sciences & Engineering

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