Search Results - collaboration+sought

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MmabΔ3-7/Δ3-7 mouse model of metabolism of cobalamin associated B (MMAB) for the study of methylmalonic acidemia (MMA)
Isolated Methylmalonic Acidemia (MMA) comprises a relatively common and heterogeneous group of inborn errors of metabolism. One cause of isolated MMA is genetic deficiency of the enzyme ATP:cob(I)alamin adenosyltransferase encoded by the metabolism of cobalamin associated B (MMAB) gene. MMAB deficiency, also called the cobalamin B type (cblB) of MMA...
Published: 5/28/2026   |   Updated: 5/28/2026   |   Inventor(s): Charles Venditti, Eun-Young Choi
Keywords(s):  
Category(s): Application > Research Materials, TherapeuticArea > Rare/Neglected Diseases, ResearchProducts, ResearchProducts > Animal Models, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Collaboration Sought > Materials Available
A Novel Strategy to Produce 6-cys Proteins Based on Pfs230D1 Domain Fusions
The Plasmodium parasite has a complex lifecycle during human infection and in the mosquito vector. Most advanced malaria vaccine candidates can confer only partial, short-term protection in malaria-endemic areas. A means of breaking the transmission of malaria to subsequent individuals could prevent a significant amount of human disease. The primary...
Published: 5/14/2026   |   Updated: 5/14/2026   |   Inventor(s): Patrick Duffy, Jonathan Renn
Keywords(s):  
Category(s): Application, Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Sequences, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Novel malaria vaccine candidates comprising engineered nanoparticles
Using proteins derived from the malaria Plasmodium falciparum parasite, NIAID has developed three different nanoparticle platforms to serve as scaffolds for displaying multiple copies of malaria antigens in an organized, repetitive manner to enhance vaccine effectiveness. The first platform uses the pyridoxal 5’-phosphate (PLP) synthase protein...
Published: 5/14/2026   |   Updated: 3/23/2026   |   Inventor(s): Niraj Tolia, Dashuang Shi, Vu Nguyen, Thayne Dickey
Keywords(s):  
Category(s): TherapeuticArea, ResearchProducts, Collaboration Sought, Application > Vaccines
Gene Editing for ALPK1 p.Thr237Met
ROSAH syndrome is a rare genetic disease caused by a mutation in the human alpha kinase 1 (ALPK1) gene (p.Thr237Met), leading to vision loss, swollen optic nerves, dry mouth, enlarged spleen, and frequent headaches. Researchers in the Laboratory of Clinical Immunology and Microbiology (LCIM) at the National Institute of Allergy and Infectious Diseases...
Published: 3/26/2026   |   Updated: 3/23/2026   |   Inventor(s): Christina Kozycki, Colin Sweeney, Uimook Choi
Keywords(s):  
Category(s): Application, Collaboration Sought, ResearchProducts, TherapeuticArea, TherapeuticArea > Rare/Neglected Diseases
Anti-Nucleoprotein Crimean-Congo Hemorrhagic Fever Virus Monoclonal Antibodies for Assay Creation
Crimean-Congo hemorrhagic fever (CCHF) is the most widespread form of viral hemorrhagic fever, found in Eastern and Southern Europe, the Mediterranean, northwestern China, central Asia, Africa, the Middle East, and the Indian subcontinent. Typically beginning with non-specific fever, myalgia, nausea, diarrhea, and general malaise, symptoms of infection...
Published: 7/3/2025   |   Updated: 7/3/2025   |   Inventor(s): Daniel Douek, David Hawman, Leonid Serebryannyy, Noemia Santana Lima, Chaim Schramm, Sarah Smith (Kerscher), Amy Henry, Alicen Spaulding
Keywords(s):  
Category(s): Application, Application > Diagnostics, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies, TherapeuticArea, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, TherapeuticArea > Rare/Neglected Diseases
EV-D68 Monoclonal Antibodies Isolated from Immunized Rhesus Macaques
Enterovirus D68 (EV-D68) has been linked to the widespread outbreaks of respiratory illness and acute flaccid myelitis (AFM) in the United States and Europe in 2014, 2016, and 2018. Although EV-D68 is now the most frequently encountered enterovirus (41.1% of cases), with an estimated global prevalence of 4%, there are no specific, FDA-approved therapeutic...
Published: 7/2/2025   |   Updated: 7/2/2025   |   Inventor(s): Tracy Ruckwardt, Daniel Moss, Peter Krug, Masaru Kanekiyo
Keywords(s):  
Category(s): Application, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, Collaboration Sought, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts, ResearchProducts > Antibodies, TherapeuticArea, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Treatment of Periodontal Disease via ENPPI Inhibition
This technology focuses on enhancing cementum production, a key component in treating periodontal regression. The method involves inhibiting ectonucleotide pyrophosphatase phosphodiesterases (ENPP1), enzymes that play a significant role in mineralization processes. Pyrophosphate (PPi) is known to impede the growth of hydroxyapatite crystals, essential...
Published: 12/30/2025   |   Updated: 3/20/2024   |   Inventor(s): Demetrios Braddock, Martha Somerman, Emily Chu, Vivek Thumbigere-Math, Brian Foster, Francisco Nociti
Keywords(s):  
Category(s): Application > Therapeutics, TherapeuticArea > Dental, Collaboration Sought, Collaboration Sought > Collaboration