NU 2023-045
INVENTORS John Rogers* Colin Franz* Yamin Zhang
SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment.
BACKGROUND Current drug delivery systems often rely on passive mechanisms or require external power sources and surgical removal, limiting their practicality and application. This innovative technology offers a user-defined, programmable solution that naturally dissolves in the body, representing a significant advancement in drug delivery for a wide range of diseases.
ABSTRACT This technology introduces a self-powered, light-controlled drug delivery device that is both biocompatible and bioresorbable, eliminating the need for batteries or surgical extraction. Utilizing a biodegradable reservoir and electrochemically active metal foils, the device enables controlled drug release through light exposure, presenting a significant advancement in pharmacological treatments.
APPLICATIONS
Pharmacological treatment of chronic pain
Localized drug delivery for post-surgical recovery
Targeted therapy for infectious diseases
Controlled drug release in cancer treatment
ADVANTAGES
Bioresorbable, eliminating surgical removal needs
Self-powered, requiring no external batteries
Enables precise control over drug release timing
Biocompatible, minimizing adverse body reactions
PUBLICATIONS
John Rogers et al., Self-powered, bioresorbable drug release systems, PNAS, 2023
IP STATUS
US Patent Pending