Search Results - zhiyong+wang

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Small Molecule Inhibitors Targeting OTUD4-CD73 Interaction for Immune-Cold Tumors
Application This technology introduces small molecule inhibitors, ST80 and Z22, to disrupt the protein-protein interaction (PPI) between OTUD4 and CD73. These inhibitors enhance tumor immunogenicity by reducing CD73 stabilization, improving the immune response in triple-negative breast cancer (TNBC) and other immune-cold tumors. Key Benefits ST80...
Published: 12/9/2025   |   Inventor(s): Yong Wan, Yueming Zhu, Ivet Bahar, Anupam Banerjee, Jiyoung Lee
Keywords(s): Drug Target Identification, Immunotherapy, Oncology Treatments, Small Molecule, Therapeutics
Category(s): TechPub Algolia > Drug Discovery
Mechanical Metamaterials for Ultra-Low Frequency Vibration Isolation
Background Vibration is one of the main causes of performance degradation of precision instruments, vibration noise, failure of structural parts, and human discomfort. In particular, the human body is most sensitive to vibrations in low frequency range especially for the wounded and newborn babies in transit. Thus, effective low-frequency vibration...
Published: 2/13/2025   |   Inventor(s): Hanqing Jiang, Lingling Wu, Yong Wang, Qianxuan Wang
Keywords(s): Mechanical and Manufacturing
Category(s): Physical Science, Manufacturing/Construction/Mechanical
Plasma Treatment to Strengthen Diamonds
Invention SummaryThis invention is applicable to toughening diamonds—that is, to improvements in the wear resistance and/or hardness of natural or synthetic diamond. The treatment is an immersion of the diamond in a low-temperature plasma environment. The plasma cations penetrate into the diamond material. The small ion with an available reactive...
Published: 6/11/2015   |   Inventor(s): Zhiyong Wang, William Wang
Keywords(s):  
Category(s): Engineering & Manufacturing, Energy & Environment, All
A New Oxyma Derivative for Amide-Forming Reactions in Water
Reference: PD 12110Technical Field:Research Tool: Chemical ReagentBackground:In amide-forming reactions with R-amino acids, the use of a coupling additive such as benzotriazole derivatives [e.g., 1-hydroxy-7-azabenzotriazole (HOAt) and hydroxybenzotriazole (HOBt)] is essential to suppress racemization and improve the efficacy of peptide synthesis.Oxyma,...
Published: 9/23/2020   |   Inventor(s): Michio Kurosu, Qinghui Wang, Yong Wang
Keywords(s): Chemical reagent, Peptide synthesis, Peptides, Research Tools and Reagents
Category(s): Chemistry & Materials