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SPLICER: Small Molecule-Inducible Gene Expression Switches
Enables Ligand-Inducible Regulation of Gene Expression or Knockdown This small molecule-inducible gene expression based on riboswitches (SPLICER) enables precise, drug-responsive control of gene expression for safer and more flexible gene and cell therapies. In mammalian cells, alternative splicing greatly expands the diversity of RNA sequences. These...
Published: 9/2/2025   |   Inventor(s): Eric Wang, Yu Zhou
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Research Tools > Therapeutics
Large-Area Solution-Processed Ionomer-Interlayered Bulk Monolayer MOS2 Membranes With Thickness-Scalable Bright Luminescence and Dual Electron-Ion Transport (Case No. 2025-281)
Summary: UCLA researchers have developed a novel hybrid 2D material platform that significantly improves the utility and optical performance of monolayer molybdenum disulfide (MoS2) by integrating a Nafion interlayer. Background: Monolayer transition metal dichalcogenides (TMDs), particularly MoS2, have shown promise in the fields of optics and...
Published: 8/7/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Boxuan Zhou
Keywords(s):  
Category(s): Materials, Materials > Functional Materials, Materials > Semiconducting Materials, Materials > Membranes, Materials > Composite Materials, Electrical, Electrical > Flexible Electronics, Electrical > Electronics & Semiconductors, Electrical > Sensors, Chemical, Chemical > Chemical Sensors, Chemical > Polymers
Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 7/31/2025   |   Inventor(s): Yi Lu, Yu Zhou
Keywords(s):  
Category(s): Life sciences > Metabolic engineering
A General Cation-Exchange Approach to Magnetic Intercalation Superlattices (Case No. 2025-9A1)
Summary: UCLA researchers in the Department of Chemistry have developed a general cation-exchange approach for tunable magnetic intercalation superlattices. Background: Layered materials are crucial for engineering quantum and magnetic phenomena at the atomic scale. Magnetic intercalation superlattices, a type of layered materials, enable tunable...
Published: 7/24/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Jingxuan Zhou
Keywords(s): Advanced Computing / AI, advanced packaging, Cation exchange, doping control, Fabrication Technologies, ferromagnetic semiconductor, layered materials, magnetic coupling, magnetic intercalation superlattices, quantum communication, Quantum Computer, quantum computing materials, Quantum Dot, quantum error correction (QEC), quantum incompressible fluid, quantum key, quantum network, quantum processing, quantum processor, room-temperature superconductivity, spin textures, spintronics, trapped ion quantum processor, tunable ferromagnetism, Van der Waals, Van Der Waals Force, VIN group metals
Category(s): Materials, Materials > Nanotechnology, Materials > Functional Materials, Materials > Semiconducting Materials, Materials > Fabrication Technologies, Materials > Metals, Optics & Photonics
Exceptional Point Optomechanical Infrared Thermal Imaging Detector (EPOPTIM)
Background Mid to long-wave infrared detectors capture and interpret infrared radiation emitted by objects, and convert it into additional data. These detectors have wide ranging applications including gas sensing, thermal imaging, environmental monitoring, and defense applications. Typically, these detectors use micro- or nano-scale microwave-frequency...
Published: 7/24/2025   |   Inventor(s): Yu Yao, Linbo Shao, Yizheng Zhu
Keywords(s):  
Category(s): Physical Science, Imaging, Environmental, Applied Technologies
Integrated Sensing and Communication System Using Backscattering RFID Tags
Background Integrated sensing and communication (ISAC) has been envisioned to benefit various emerging applications in the future, with enhanced spectral, energy, and hardware efficiency. One potential scenario is the use of radio frequency identification (RFID) for inventory management in warehouses or retail stores, where low-cost passive RFID tags...
Published: 7/14/2025   |   Inventor(s): Ahmed Alkhateeb, Hao Luo, Umut Demirhan
Keywords(s):  
Category(s): Physical Science, Wireless & Networking, Energy & Power, Applied Technologies
Surface Oxophilic Single Atom Decoration of PT Catalyst for Anion Exchange Membrane Fuel Cells (Case No. 2025-263)
Summary: Researchers at UCLA's Department of Chemistry and Biochemistry have developed a novel catalyst design using oxophilic single-atom decorations that enhances the performance and durability of platinum (Pt) catalysts in alkaline exchange membrane fuel cells. Background: Hydrogen fuel cells are a promising alternative to internal combustion...
Published: 6/24/2025   |   Inventor(s): Xiangfeng Duan, Yu Huang, Chengzhang Wan
Keywords(s): anion exchange membrane fuel cells (AEMFCs), Catalysts, catalytic hydrogenation, clean energy, clean energy consumption, clean material production, Composite Material, Composite Materials, Construction Materials, Electrocatalyst, electrochemically active surface area, high-durability catalysts, Hydrogen, Hydrogen oxidation reaction, hydrogen oxidation reaction (HOR), hydrogen production, low overpotential catalysis, mass activity, material science, Materials, meta materials, Methane Reformer Hydrogen Production, microarchitectured materials, Nanomaterials, nanostructured materials, Nanotechnology, oxygen oxidation reaction, oxygen reduction reaction (ORR), Platinum group metal catalysts, proton exchange membrane fuel cells (PEMFCs), proton exchange water membrane electrolyzer (PEMWE), Rhodium-decorated Platinum nanowires (SARh-PtNW), specific activity, transition metal catalysts
Category(s): Materials, Materials > Nanotechnology, Materials > Functional Materials, Energy & Environment, Energy & Environment > Energy Generation, Energy & Environment > Energy Efficiency, Energy & Environment > Energy Transmission, Chemical, Chemical > Chemical Processing & Manufacturing, Chemical > Synthesis, Chemical > Catalysts
Multi-Object Grasping -- Grasping from Surface of Pile
Advantages: High Efficiency in Cluttered Environments Vision-Guided Dexterity with 6D Pose Estimation Confidence-Driven Grasp Optimization Adaptive to Real-World Variability Scalable for Industrial Automation Summary: Robotic grasping in industries like manufacturing, warehousing, and logistics is still a bottleneck when dealing with dense...
Published: 5/28/2025   |   Inventor(s): Tianze Chen, Yu Sun
Keywords(s): Robotics
Category(s): Technology Classifications > Engineering > Chemical Engineering, Technology Classifications > Engineering > Mechanical Engineering, Technology Classifications > Engineering > Industrial Engineering
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Multi-material electrospinning system for 3D-printed fiber architectures
Background Electrospinning and additive manufacturing have become increasingly important in fields such as biotechnology, pharmaceuticals, and tissue engineering, where there is growing demand for complex fiber architectures and multifunctional material systems. However, traditional electrospinning methods struggle to meet the precision, scalability,...
Published: 4/25/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi, Ishaan Duggal
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
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