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Search Results - yiliang+luan
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Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025
|
Inventor(s):
Yi Lu
,
Quanbing Mou
Keywords(s):
Category(s):
Life sciences > Imaging
,
Life sciences > Research tools > Tool/assay/screening platform
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 1/31/2025
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Inventor(s):
Yi Lu
,
Zhenglin Yang
,
Huanhuan Fan
Keywords(s):
Category(s):
Life sciences > Biomaterials
DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s. Background Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 1/31/2025
|
Inventor(s):
Yi Lu
,
Seyed-Fakhreddin Torabi
,
Yuting Wu
,
Ryan Lake
,
Zhenglin Yang
,
Peiwen Wu
,
Whitney Lewis
,
Jacqueline Van Stappen
,
Xiangli Shao
Keywords(s):
Category(s):
Life sciences > Biomaterials
DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance. Background The field of biochemical research and medical diagnostics increasingly...
Published: 1/14/2025
|
Inventor(s):
Yi Lu
,
Whitney Lewis
,
Yuan Ma
Keywords(s):
Category(s):
Life sciences > Therapeutics > Drug screening
,
Life sciences > Research tools > Tool/assay/screening platform
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024
|
Inventor(s):
Yi Lu
,
Yuan Ma
,
Weijie Guo
,
Quanbing Mou
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
Potent And-1 Inhibitors that Suppress Tumor Growth and Overcome Platinum Drug Resistance
Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. Recent studies showed that the Acidic nucleoplasmic DNA-binding protein 1 (And-1) activation promotes platinum drug resistance...
Published: 2/18/2025
|
Inventor(s):
Wenge Zhu
,
Yiliang Li
,
Jing Li
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Small Molecules
SENP1 Enzymatic Activity Inhibitors for Platinum Resistant Ovarian Cancer
Ovarian cancer is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. A recent study indicated that Janus tyrosine kinase 2 (JAK2), which activates the signal transducers and activators of transcription...
Published: 2/18/2025
|
Inventor(s):
Wenge Zhu
,
Jing Li
,
Ruiqin Wu
,
Yiliang Li
Keywords(s):
Category(s):
Technology Classifications > Therapeutics > Small Molecules
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Nature-inspired Functionally-graded UHMWPE + Kevlar Composites Achieve Extraordinarily High Strength
Nature-inspired polymers are achieved using unique processing to yield functional gradient composites with embedded Kevlar fibers exhibiting extraordinarily high strength lightweight UHMWPE materials. Background: Demand for new energy absorption materials and implantable polymeric biomaterials has increased significantly in recent years. The...
Published: 1/28/2025
|
Inventor(s):
Shenqiang Ren
,
Lu An
Keywords(s):
Technologies
Category(s):
Campus > University at Buffalo
,
Technology Classifications > Materials and Chemicals
,
Technology Classifications > Nanotechnology
,
Technology Classifications > Engineering
High-Throughput Microfluidic Instrument for Constructing Custom Synthetic Vesicles with Asymmetric Membranes
Microfluidic device for constructing custom synthetic vesicles with controlled asymmetry Background: The ability to fabricate complex model membrane systems that are physiologically relevant to their natural systems has been a challenge in past decades. Conventional methods such as electroformation, gel hydration, bulk inverted emulsion, extrusion,...
Published: 12/28/2023
|
Inventor(s):
Li Lu
,
Sepehr Maktabi
,
Paul Chiarot
,
Jeffrey Schertzer
Keywords(s):
Category(s):
Technology Classifications > Biomedical Science and Engineering
,
Campus > Binghamton University
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