Search Results - yi+luo

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Biocompatible photoenzymatic system for selective C–H fluorination
Background C–H fluorination plays a central role in pharmaceutical and agrochemical synthesis, as the introduction of fluorine often enhances a molecule's metabolic stability, potency, and bioavailability. Over 20% of approved drugs contain fluorinated functional groups, underscoring the demand for efficient and selective fluorination methods....
Published: 7/31/2025   |   Inventor(s): Yi Lu, Yu Zhou
Keywords(s):  
Category(s): Life sciences > Metabolic engineering
DNA-based sensors for live-cell mapping of metabolite- and metal ion-protein interactions
Background Understanding how metabolites and metal ions interact with proteins inside living cells is essential for decoding cellular signaling, metabolic regulation, and disease mechanisms. These small molecules function as cofactors, second messengers, and allosteric regulators, orchestrating critical pathways that govern cell behavior. However,...
Published: 6/16/2025   |   Inventor(s): Yi Lu, Mandira Banik
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Immunology > Genomics/genetics
Artificial nitrogenase enzymes for ambient-condition, decentralized ammonia production
Background Ammonia synthesis is foundational to global agriculture and chemical manufacturing, providing the primary source of fixed nitrogen for fertilizers, polymers, and pharmaceuticals. Traditional ammonia production through the Haber-Bosch process, however, operates under extreme conditions—temperatures exceeding 400°C and pressures...
Published: 7/2/2025   |   Inventor(s): Yi Lu, Hirbod Heidari, Markus Ribbe, Yilin Hu, Chi Chung Lee, Evan Mirts
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Metabolic engineering
Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution. Background Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025   |   Inventor(s): Yi Lu, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Research tools > Tool/assay/screening platform
DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies. Background Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 5/19/2025   |   Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s. Background Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 7/31/2025   |   Inventor(s): Yi Lu, Seyed-Fakhreddin Torabi, Yuting Wu, Ryan Lake, Zhenglin Yang, Whitney Lewis, Jacqueline Van Stappen, Xiangli Shao
Keywords(s):  
Category(s): Life sciences > Biomaterials
DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance. Background The field of biochemical research and medical diagnostics increasingly...
Published: 6/17/2025   |   Inventor(s): Yi Lu, Whitney Besetzny, Yuan Ma
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Research tools > Tool/assay/screening platform
ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/3/2025   |   Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform
Virtual Impactor-Based Label-Free Bio-Aerosol Detection Using Holography and Deep Learning (Case No. 2023-037)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a virtual aerosol detection method that combines imaging and deep learning to sense and classify bio-aerosols without any external labeling or post processing steps. Background: Bio-aerosol detection and classification is pivotal to understanding and...
Published: 2/14/2025   |   Inventor(s): Aydogan Ozcan, Yi Luo, Tairan Liu
Keywords(s): air quality measurement, Artificial Neural Network, bioterrorism, computational imaging, Deep learning-based sensing, Digital Electronics, Digital Holography, Digital Signal Processing, Imaging, label-free imaging, label-free sensing, Mass Spec, pollen detection, Sensors, virtual impactors
Category(s): Electrical, Electrical > Sensors, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Mass Spectrometry
Class-Specific Diffractive Cameras with All-Optical Erasure of Undesired Objects (Case No. 2022-287)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel camera design that is capable of target-specific imaging with instantaneous optical erasure of irrelevant objects. Background: There are over 1 billion surveillance cameras around the world today, and the installation of such video surveillance...
Published: 6/18/2025   |   Inventor(s): Aydogan Ozcan, Yi Luo, Bijie Bai
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Artificial Neural Network, Camera, Cameras, Computer Vision, Deep Learning, Surveillance
Category(s): Electrical, Electrical > Imaging, Electrical > Signal Processing, Software & Algorithms > Artificial Intelligence & Machine Learning
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