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Precision cellular imaging for advanced biological analysis
A novel DNA-based imaging technique enabling visualization of 3D cellular components with super-resolution.
Background
Super-resolution microscopy has revolutionized biological research by providing finer details beyond the diffraction limit of conventional microscopy. A particular challenge in this field is the visualization of small and dynamic...
Published: 3/4/2025
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Inventor(s): Yi Lu, Quanbing Mou
Keywords(s):
Category(s): Life sciences > Imaging, Life sciences > Research tools > Tool/assay/screening platform
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DNAzyme sensor for selective manganese ion detection in biological systems
A selective DNAzyme-based fluorescent sensor detects manganese ions in cells by lighting up when Mn²⁺ binds, allowing precise monitoring of manganese levels for biological research and potential therapies.
Background
Manganese (Mn²⁺) is an essential trace element integral to numerous biological processes, acting as a vital cofactor for enzymes...
Published: 1/31/2025
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Inventor(s): Yi Lu, Zhenglin Yang, Huanhuan Fan
Keywords(s):
Category(s): Life sciences > Biomaterials
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DNAzyme fluorescent sensors for bioselective imaging of Fe²⁺ and Fe³⁺ ions
Developed DNAzyme-based fluorescent sensors that specifically detect and image Fe2⁺ and Fe3⁺ ions in living cells, enabling the study of iron dynamics in biological processes and diseases like Alzheimer’s.
Background
Iron ions, specifically Fe2⁺ and Fe3⁺, are essential for numerous biological processes, including oxygen transport, DNA synthesis,...
Published: 1/31/2025
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Inventor(s): Yi Lu, Seyed-Fakhreddin Torabi, Yuting Wu, Ryan Lake, Zhenglin Yang, Peiwen Wu, Whitney Lewis, Jacqueline Van Stappen, Xiangli Shao
Keywords(s):
Category(s): Life sciences > Biomaterials
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DNA aptamer technology for Coenzyme A detection and cellular imaging
Researchers developed a DNA aptamer that specifically targets Coenzyme A, enabling easy and accurate detection in cells. This technology is more specific and simpler than current methods, supporting diagnostics, research, and treatments for diseases involving CoA imbalance.
Background
The field of biochemical research and medical diagnostics increasingly...
Published: 1/14/2025
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Inventor(s): Yi Lu, Whitney Lewis, Yuan Ma
Keywords(s):
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Research tools > Tool/assay/screening platform
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ARPLA: a revolutionary glycoRNA imaging tool with precision and power
Background/problem
Glycosylated RNAs (GlycoRNAs) are a newly discovered class of molecules involved in glycosylation. They have been found on the surfaces of various cell types, organisms, and species, further advancing the role of RNA in biological processes. Despite this, our knowledge of glycoRNAs and their functions remains limited, primarily...
Published: 7/26/2024
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Inventor(s): Yi Lu, Yuan Ma, Weijie Guo, Quanbing Mou
Keywords(s):
Category(s): Life sciences > Research tools > Tool/assay/screening platform
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Virtual Impactor-Based Label-Free Bio-Aerosol Detection Using Holography and Deep Learning (Case No. 2023-037)
Summary:
UCLA researchers in the Department of Electrical and Computer Engineering have developed a virtual aerosol detection method that combines imaging and deep learning to sense and classify bio-aerosols without any external labeling or post processing steps.
Background:
Bio-aerosol detection and classification is pivotal to understanding and...
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Yi Luo, Tairan Liu
Keywords(s): air quality measurement, Artificial Neural Network, bioterrorism, computational imaging, Deep learning-based sensing, Digital Electronics, Digital Holography, Digital Signal Processing, Imaging, label-free imaging, label-free sensing, Mass Spec, pollen detection, Sensors, virtual impactors
Category(s): Electrical, Electrical > Sensors, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Mass Spectrometry
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Class-Specific Diffractive Cameras with All-Optical Erasure of Undesired Objects (Case No. 2022-287)
Summary:
UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel camera design that is capable of target-specific imaging with instantaneous optical erasure of irrelevant objects.
Background:
There are over 1 billion surveillance cameras around the world today, and the installation of such video surveillance...
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Yi Luo, Bijie Bai
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Intelligence, Artificial Neural Network, Camera, Cameras, Computer Vision, Deep Learning, Surveillance
Category(s): Electrical, Electrical > Imaging, Electrical > Signal Processing, Software & Algorithms > Artificial Intelligence & Machine Learning
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2021-359 Seeing Through Random Diffusers Without a Computer
Summary:
UCLA researchers in the department of Electrical and Computer Engineering have developed an all optics-based system that can perform image reconstruction at the speed of light for images distorted by light scattering and diffusion.
Background:
Imaging is an essential technique for everything from biomedical optics and atmospheric physics...
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Yi Luo, Ege Cetintas, Yair Rivenson
Keywords(s): Automation, Computer Vision, Digital Electronics, Electronics & Semiconductors, Optics, Photonics, Remote Sensing, Robotics, Signal Reconstruction, Turbines
Category(s): Electrical, Electrical > Electronics & Semiconductors, Electrical > Imaging, Mechanical, Mechanical > Instrumentation, Mechanical > Robotics, Optics & Photonics
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2021-333 Quantitative Particle Agglutination Assay for Point-Of-Care Testing Using Mobile Holographic Imaging and Deep Learning
Summary:
UCLA researchers in the Department of Electrical and Computer Engineering have developed a method that increases the sensitivity of particle agglutination assays and reduces the required sample volume.
Background:
Particle agglutination assays are simple immunological tests that can be utilized to diagnose a wide range of illnesses. These...
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Hyouarm Joung, Yi Luo
Keywords(s):
Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics > Holography
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2020-174 Design of Task-Specific Optical Systems Using Broadband Diffractive Neural Networks
UC Case No. 2020-174SUMMARYUCLA researchers in the Department of Electrical and Computer Engineering have developed a diffractive neural network that can process an all-optical, 3D printed neural network for deep learning applications.BACKGROUNDDeep learning, a method of machine learning that mimics the human brain’s connectivity through a series...
Published: 2/14/2025
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Inventor(s): Aydogan Ozcan, Yi Luo, Deniz Mengu, Yair Rivenson
Keywords(s):
Category(s): Software & Algorithms > Image Processing, Software & Algorithms > Artificial Intelligence & Machine Learning
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