Search Results - xiaolin+zhong

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DHODH Inhibitors
This technology includes novel compounds that selectively inhibit fungal dihydroorotate dehydrogenase (DHODH), an essential enzyme in pyrimidine biosynthesis. These inhibitors are active against a range of fungal pathogens, including Cryptococcus neoformans and Candida auris, while sparing the human version of the enzyme. This selectivity reduces the...
Published: 8/18/2025   |   Inventor(s): Hongmin Li, Anil Tharappel, Zhong Li
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Small Molecules
Ease-of-manufacture Highly Transparent Thin Polyvinyl Alcohol Aerogel
Energy-efficient and cost-effective method for manufacturing transparent and robust PVA aerogels for green energy applications Background: Aerogels, particularly silica-based variants, have been widely used for their exceptional thermal insulation and transparency. However, their fragility has posed significant challenges for broader applications,...
Published: 6/13/2025   |   Inventor(s): Yi Zheng, Xiaoli Li
Keywords(s):  
Category(s): Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 2. Physical Science > Environmental/Clean tech
BASH-GN: A New Machine Learning–Derived Questionnaire for Screening Obstructive Sleep Apnea
BASH-GN is a machine learning-based questionnaire designed to classify the risk of obstructive sleep apnea (OSA) by considering various risk factor subtypes. Compared with other commonly used OSA screening tools, the BASH-GN questionnaire demonstrated superior performance, making it a more effective option for identifying at-risk individuals. This questionnaire...
Published: 9/23/2024   |   Inventor(s): Ao Li, Jiayan Huo, Stuart Quan, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Sleep Disorders
A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting
The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...
Published: 2/26/2025   |   Inventor(s): Ao Li, Ping Chang, Huayu Li, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Web & Internet
MTS-LOF: Medical Time-Series Representation Learning via Occlusion-Invariant Features
Medical Time Series Representation Learning, known as MTS-LOF, uses the strengths of contrastive learning and Masked Autoencoder (MAE) methods, providing more sophisticated, context-rich representations, while also clarifying the interplay between temporal and structural dependencies in healthcare data. MTS-LOF is ideal for integration into numerous...
Published: 2/26/2025   |   Inventor(s): Ao Li, Huayu Li, Ana Carreon-Rascon
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Web & Internet, Technology Classifications > Software & Information Technology > Health IT
Deep Learning Algorithm for Detection of Cortical Arousal During Sleep
This invention is an end-to-end deep learning algorithm to detect cortical arousals during sleep using a one-night single lead electrocardiogram (ECG) signal. It is used to accurately detect arousal in home sleep tests, by reducing the false negative rate. The model combines both convolutional neural networks (CNN) and recurrent neural networks (RNN). Background: Sleep...
Published: 7/8/2025   |   Inventor(s): Ao Li, Siteng Chen, Stuart Quan, Linda Powers, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Sleep Disorders, Technology Classifications > Software & Information Technology > Health IT
Small Molecules with Antifungal Activity for Cryptococcosis
Researchers at the University of Arizona have found 140 novel antifungal compounds with the potential to treat cryptococcosis. These compounds have anti-Cryptococcus neoformans activity with IC50 less than 10 uM. Background: Fungal infections, although not very contagious, have affected 300 million people worldwide. Cryptococcosis is caused by opportunistic...
Published: 1/10/2024   |   Inventor(s): Hongmin Li, Anil Tharappel, Zhong Li
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Broad Spectrum Inhibitors against Viral Methyltransferases
This innovation is a universal high throughput screening (HTS) assay to identify inhibitors targeting a binding site of viral methyltransferases (MTases) with a methyl donor. The inventors developed a fluorescence polarization (FP)-based HTS assay to target reference MTases, an essential enzyme to methylate the 5’-cap of viral RNA genome on SARS-CoV-2...
Published: 11/16/2023   |   Inventor(s): Hongmin Li, Zhong Li
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Infectious Diseases
Virtual Reality Neuropsychological Assessment (VRNA) System
This technology is a computerized neuropsychological assessment system to rapidly measure cognitive and behavioral abilities and impairments. This system operates by extracting multiple, simultaneous performance metrics while the patient is in a virtual reality (VR) game-like scenario. As the patient is playing this challenging VR video game, the VRNA...
Published: 3/14/2025   |   Inventor(s): William Killgore, Janet Roveda, Jerzy Rozenblit, Ao Li, Huayu Li
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Physical Medicine & Rehabilitation, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Mobile Application, Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Software & Information Technology
Allosteric Inhibitors of the Main Protease of SARS-CoV-2
In this report, the SARS-CoV-2 3CLpro was expressed and purified. By using a FRET-based enzymatic assay, the researchers have screened a library consisting of more than 300 different niclosamide derivatives and identified three molecules JMX0286, JMX0301, and JMX0941 as potent allosteric inhibitors against SARS-CoV-2 3CLpro, with IC50 values like that...
Published: 4/1/2024   |   Inventor(s): Hongmin Li, subodh samrat, Zhong Li, Jia Zhou, Jimin Xu
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases
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