Search Results - xiaolin+nan

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BASH-GN: A New Machine Learning–Derived Questionnaire for Screening Obstructive Sleep Apnea
BASH-GN is a machine learning-based questionnaire designed to classify the risk of obstructive sleep apnea (OSA) by considering various risk factor subtypes. Compared with other commonly used OSA screening tools, the BASH-GN questionnaire demonstrated superior performance, making it a more effective option for identifying at-risk individuals. This questionnaire...
Published: 9/23/2024   |   Inventor(s): Ao Li, Jiayan Huo, Stuart Quan, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Sleep Disorders
A Transformer-Based Diffusion Probabilistic Model for Vital Signs Forecasting
The model proposed in this technology, Transformer-based Diffusion Probabilistic Model for Sparse Time Series Forecasting (TDSTF), is a novel deep-learning algorithm that can be used for vital signs forecasting, data synthesis, simulation, and digital twins. Trained and tested on data from over 46,000 patients, the TDSTF technology merges transformer...
Published: 8/23/2024   |   Inventor(s): Ao Li, Ping Chang, Huayu Li, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Software & Information Technology > Web & Internet
MTS-LOF: Medical Time-Series Representation Learning via Occlusion-Invariant Features
Medical Time Series Representation Learning, known as MTS-LOF, uses the strengths of contrastive learning and Masked Autoencoder (MAE) methods, providing more sophisticated, context-rich representations, while also clarifying the interplay between temporal and structural dependencies in healthcare data. MTS-LOF is ideal for integration into numerous...
Published: 8/23/2024   |   Inventor(s): Ao Li, Huayu Li, Ana Carreon-Rascon
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Web & Internet, Technology Classifications > Software & Information Technology > Health IT
DeScoD-ECG: Deep Score-Based Diffusion Model for ECG Baseline Wander and Noise Removal
The DeScoD-ECG model is a novel electrocardiogram (ECG) baseline wander and noise removal technology that extends the current diffusion model for reconstructing electrocardiogram signals. It establishes a new benchmark in biomedical signal processing to provide a more accurate approximation of ECG signals for detection of cardiovascular irregularities....
Published: 8/23/2024   |   Inventor(s): Ao Li, Huayu Li, Gregory Ditzler, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Communications & Networking, Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics
Deep Learning Algorithm for Detection of Cortical Arousal During Sleep
This invention is an end-to-end deep learning algorithm to detect cortical arousals during sleep using a one-night single lead electrocardiogram (ECG) signal. It is used to accurately detect arousal in home sleep tests, by reducing the false negative rate. The model combines both convolutional neural networks (CNN) and recurrent neural networks (RNN). Background: Sleep...
Published: 8/23/2024   |   Inventor(s): Ao Li, Siteng Chen, Stuart Quan, Linda Powers, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Sleep Disorders, Technology Classifications > Software & Information Technology > Health IT
High Affinity Cross Species Single Domain Antibodies Targeting Mesothelin
Abstract: Mesothelin is a cell surface protein that is an excellent target for immunotherapy because of its limited expression on normal tissues and its high expression on many cancers, including mesothelioma, cholangiocarcinoma, pancreatic, ovarian, lung, stomach, bile duct, and triple-negative breast cancer. Researchers at the National Cancer Institute’s...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Ira Pastan, Jessica Hong, Nan Li
Keywords(s): ADC, Antibody-drug Conjugate, Bispecific Antibody, CAR, chimeric antigen receptor, HO, MESOTHELIN, Mesothelioma, Recombinant Immunotoxins, RITs
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics
Anti-Glypican 2 Chimeric Antigen Receptor (CAR) Containing CD28 Hinge And Transmembrane Domains For Treating Neuroblastoma
Abstract: Neuroblastomas are the most common extracranial solid tumors in pediatric patients, with 700-800 new cases annually in the United States. Metastatic neuroblastomas have a five-year survival rate of 50% and account for 15% of all pediatric cancer deaths. As such, more effective treatments against high-risk neuroblastomas are urgently needed....
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Carol Thiele Galetto, Nan Li, Rosa Nguyen, Rosandra Kaplan
Keywords(s): CAR, chimeric antigen receptor, Glypican 2, GPC2, HO, Immunotherapy, Medulloblastoma, Neuroblastoma, Retinoblastoma, Small-Cell Lung Cancers
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Human Monoclonal Antibodies Targeting Glypican-2 in Neuroblastoma
Abstract: Neuroblastoma is a rare pediatric cancer that affects one in every hundred thousand children under the age of fifteen in the United States. Current standards of care  are chemotherapy and surgery, followed by stem-cell treatments, radiation and anti-ganglioside antibody therapy, which yield an average three-year survival rate of 10-45%. This...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Dimiter Dimitrov
Keywords(s): ADC, ANTIBODY, Antibody-drug Conjugate, Bispecific Antibody, CAR, chimeric antigen receptor, Glypican-2, GPC2, Immunotoxin, Neuroblastoma, Recombinant Immunotoxin, Rit
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
High Affinity Monoclonal Antibodies Targeting Glypican-2 for Treating Childhood Cancers
Abstract: Neuroblastoma is a rare pediatric cancer with approximately 1,000 new cases arising annually. Current therapies have a less than forty-five percent (45%), three-year survival rate which demonstrate a need for a more effective treatment against this disease. Glypican-2 (GPC2) is a cell surface protein that is preferentially expressed in pediatric...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Bryan Fleming
Keywords(s): ADC, Antibody-drug Conjugate, CAR, chimeric antigen receptor, Glypican 2, GPC2, HO, Immunotoxin, Medulloblastoma, Neuroblastoma, Recombinant Immunotoxin, Retinoblastoma, Rit
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing
New Chimeric Antigen Receptor (CAR) Format for Developing Improved Adoptive Cell Therapies
Abstract: Adoptive cell therapy (ACT) is an attractive new therapeutic approach for treating various cancers. ACT has recently demonstrated a high degree of efficacy when treating patients with hematological malignancies. However, to date, no effective Chimeric Antigen Receptors (CAR) T cell therapy exists for solid tumors. Researchers in the National...
Published: 5/21/2024   |   Inventor(s): Mitchell Ho, Nan Li, Dan Li
Keywords(s): CANCER, chimeric antigen receptor (CAR), GPC2, GPC3, HO, MESOTHELIN, solid tumor, tumor antigen
Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
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