Search Results - venkataramana+rao

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Development of genetically engineered probes for calcium sensing and manipulation
Calcium levels in cells have critical functions. Moreover, calcium signaling plays a crucial role in the control of neuronal function and plasticity. Consequently, calcium sensing dysfunction can lead to a variety of pathological conditions such as Alzheimer’s disease or neuromuscular disorders such as Dystonia. Changes in neuronal Ca2+ concentration...
Published: 3/4/2024   |   Inventor(s): Venkat Venkataraman, Anuradha Krishnan, Jeffrey Viviano, Jingyi Zhang
Keywords(s): Alzheimer's, Calcium, Genetics, Neurology, Neuromuscular
Category(s): Human Health Care > Therapeutics
Neuronal calcium sensor proteins as potential therapeutic targets in circadian rhythm and sleep disorders
Sleep health and sleep disorders are major problems. In the US, an estimated 1/3rd of adults and 2/3rds of highschool aged young adults do not get the recommended amount of sleep. Lack of sleep and poor sleep hygiene is associated with a number of health problems. These include obesity, depression, and cardiovascular disease. Additionally, specific...
Published: 3/5/2024   |   Inventor(s): Venkat Venkataraman
Keywords(s): Circadium, Genetics, Sleep, Therapeutic
Category(s): Human Health Care > Therapeutics
A new serum-based diagnostic for the detection of substance abuse and other addictive disorders
The proposed technology is a novel approach to a serum biomarker for substance abuse disorder based on the positive correlation between plasma S100B protein levels and addiction. It is proposed that the expression levels of the S100B protein will serve as an indicator of the process of addiction and decision-making. The changes may be detectable in...
Published: 2/13/2024   |   Inventor(s): Venkat Venkataraman, Richard Jermyn, Robert Steer
Keywords(s): Addiction, Biomarkers, Diagnostics, Substance Abuse
Category(s): Human Health Care > Biomarkers, Diagnosis and Detection
2014-864 ApoE4-Targeted Therapeutics that Increase SIRT1
ApoE4-Targeted Theraputics That Increase SIRT1SUMMARYUCLA researchers have identified Alaproclate (A03) as a promising drug candidate to treat Mild Cognition Impairment (MCI) and Alzheimer’s disease (AD) through inhibition of the ApoE4 neurotoxicity.BACKGROUNDAlzheimer’s disease (AD) is a neurodegenerative disease whose cause is largely...
Published: 7/19/2023   |   Inventor(s): Michael Jung, Varghese John, Dale Bredesen, Barbara Jagodzinska, Jesus Campagna, Ram Rao, Johnny Pham
Keywords(s):  
Category(s): Therapeutics, Therapeutics > CNS and Neurology
A Molecular Scaffold for Colonic Drug Delivery
A molecule which passes through the gastrointestinal tract was successfully synthesized and tested for GI MRI imaging in mice. A molecular scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. This contrast agent...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr., Pawel Kiela, Fayez Ghishan, Suryakiran Navath, Venkataramana Rao, Rita Marie Woodford, Monica Midura-Kiela, Ahad Ali, Ramesh Alleti
Keywords(s): 5-aminosalicylic acid, gastrointestinal tract, inflammatory bowel disease, pro-drug
Category(s): Technology Classifications > Life Sciences > Diagnostics
A GI-Specific Contrast Agent for Magnetic Resonance Imaging
A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition in this invention. This contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by...
Published: 3/12/2024   |   Inventor(s): Eugene Mash, Jr., Suryakiran Navath, Venkataramana Rao, Ramesh Alleti, Ahad Ali, Gary Martinez, Robert Gillies, David Morse
Keywords(s): contrast agent, gastrointestinal tract, MRI
Category(s): Technology Classifications > Healthcare Portfolios > Gastroenterology Disease