Search Results - therapeutics+%3e+stem+cells+and+regenerative+medicine

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Directed Differentiation Protocols to Derive Bone Fide Spinal Sensory Interneurons (UCLA Case No. 2022-224)
UCLA researchers from the Department of Neurobiology have developed innovative protocols to differentiate and expand spinal sensory interneurons for drug discovery and to utilize in cell replacement therapies to restore injured spinal cords. BACKGROUND: Spinal cord injuries (SCIs) can result in the loss of controlled movement and somatosensation, the...
Published: 10/10/2025   |   Inventor(s): Samantha Butler
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > CNS and Neurology
Methods for Disrupting Leukemia Stem Cell Function (UCLA Case No. 2025-253)
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Published: 9/18/2025   |   Inventor(s): Hanna Mikkola
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Stem Cells And Regenerative Medicine
Vectors Combining Anti-Sickling Beta-AS3-Globin with Anti BCL11A ShRNAmir to Treat Beta-Hemoglobinopathies (UCLA Case No. 2021-190)
UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics and Pediatrics have developed a potent bi-functional lentiviral expression vector to treat sickle cell disease and beta-thalassemia. BACKGROUND: Beta-hemoglobinopathies, such as sickle cell disease and beta-thalassemia, are genetic disorders characterized by dysfunctional...
Published: 9/11/2025   |   Inventor(s): Donald Kohn
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Stem Cells And Regenerative Medicine
Small Molecule Enhancers of Secreted Clusterin (sCLU) as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2024-016)
UCLA researchers from the Department of Neurology have identified and synthesized novel small molecules that enhance the levels of secreted clusterin protein, a protein that can targets a significant risk factor for the disease, and offering promising potential for the treatment of Alzheimer’s disease. BACKGROUND: Alzheimer’s disease (AD)...
Published: 7/17/2025   |   Inventor(s): Varghese John
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Gene Therapy for DOCK8 Deficiency (UCLA Case No. 2023-178)
UCLA researchers in the Department of Pediatrics Allergy and Immunology have developed a gene therapy method to express the full-length DOCK8 protein in cells, aimed at treating DOCK8 deficiency. These method allows for safe and effective DOCK8 expression in hematopoietic stem cells without the need for an HLA-matched donor, enabling patients to undergo...
Published: 7/17/2025   |   Inventor(s): Caroline Kuo
Keywords(s): bone marrow, bone marrow transplants, DOCK8, DOCK8 deficiency, Gene Editing Systems, Gene Therapy, hematopoietic stem cells, Immune System, immunodeficiency, Immunology, intein splicing
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Life Science Research Tools > Plasmids/Vectors
Identification of a Factor That Rescues Dysregulated Endocytosis in Cultured Human Hematopoietic Stem Cells (UCLA Case No. 2023-051)
UCLA researchers in the Departments of Molecular, Cell & Developmental Biology have developed a novel method to enhance the function of hematopoietic stem cells (HSCs) to improve the transplantability of ex vivo expanded human HSCs in clinical settings. BACKGROUND: Hematopoietic stem cells (HSCs), present in blood and bone marrow, can form mature...
Published: 7/17/2025   |   Inventor(s): Hanna Mikkola, Julia Aguade Gorgorio
Keywords(s): bone marrow, bone marrow transplants, CRISPR, endocytosis, engraftment, environmental sensing, hematopoietic stem cells, leukemia, MLLT3, MYCT1, transplantability
Category(s): Therapeutics > Hematology, Life Science Research Tools, Therapeutics > Stem Cells And Regenerative Medicine
A Novel “Host-Guest”-Based Supramolecular Hydrogel for Dental Pulp Regeneration (Case No. 2023-154)
Summary: Researchers in the Department of Dentistry at UCLA have developed an innovative hydrogel for a vast array of biomedical and tissue engineering applications. Background: Hydrogels have emerged as powerful tools in biomedical engineering due to their ability to provide a supportive environment for cell growth, tissue repair, and drug delivery....
Published: 4/29/2025   |   Inventor(s): Alireza Moshaverinia, Weihao Yuan
Keywords(s): anti-dehydration, Drug Delivery, dynamic identification, hydrogel, Stem Cells / Regenerative Medicine, Targeted Therapy, tissue regeneration
Category(s): Chemical, Materials > Functional Materials, Platforms > Drug Delivery, Platforms > Drug Delivery > Antibody Delivery Platforms, Platforms > Drug Delivery > Nanoparticles, Platforms > Drug Delivery > Viral Delivery Systems, Therapeutics > Cell Therapy, Therapeutics > Medication, Therapeutics > Stem Cells And Regenerative Medicine
Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)
Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...
Published: 8/28/2025   |   Inventor(s): Michael Jung, Frank Pajonk
Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Method for Combined Conditioning and Chemoselection in a Single Cycle (UCLA Case No. 2011-478)
SUMMARY: Researchers at UCLA have developed a highly-efficient technique to engraft and select hematopoietic stem cells directly inside a patient. The invention will improve the fidelity of stem cell transplantations and reduce toxic side effects on patients. BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is a mainstay of treatment for...
Published: 7/17/2025   |   Inventor(s): Gay Crooks, Robert Schiestl, Katrin Hacke, Akos Szakmary
Keywords(s): blood cancers, Cancer stem cells, Hematopoietic stem cell transplantation, hematopoietic stem cells, lymphatic cancer, stem cell transplantations, Transplant
Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Transplant
Combining Autologous or Allogeneic Total Monocytes or CD16+ Monocytes to Protect and Increase the Expansion and Function of Stem Cells (UCLA Case No. 2021-182)
SUMMARY: UCLA researchers in the department of Dentistry have developed a novel approach to increase the successful transplantation and survival of stem cells into patients. BACKGROUND: The World Health Organization has recognized that transplantation of human cells saves and restores essential life functions to patients who are not presented with...
Published: 7/17/2025   |   Inventor(s): Anahid Jewett
Keywords(s):  
Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
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