Search Results - therapeutics+%3e+cardiovascular

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Compounds and Methods for Inducing UCP1 Expression (UCLA Case No. 2019-272)
UCLA researchers in the Department Human Genetics have identified small molecules that induce UCP1 expression and thermogenic mitochondrial activity in adipocytes, providing a novel class of potential therapeutics for obesity and related conditions. BACKGROUND: Obesity affects more than 93 million Americans and continues to rise in prevalence. Modulating...
Published: 4/14/2026   |   Updated: 3/26/2026   |   Inventor(s): Laurent Vergnes, Karen Reue
Keywords(s):  
Category(s): Therapeutics > Metabolism And Endocrinology, Therapeutics > Cardiovascular, Life Science Research Tools > Other Reagents
Novel Lipid Lowering, Anti-Atherosclerosis and Anti-Obesity Effects of Netrin-1 (UCLA Case No. 2019-728)
UCLA researchers in the Department of Anesthesiology have developed a novel and extremely robust lipid lowering, anti-atherosclerotic, and anti-obesity treatment with Netrin-1.BACKGROUND:Hyperlipidemia, an elevation of different forms of lipids in the bloodstream, is the most important risk factor for coronary heart disease, while causing many other...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Hua Cai
Keywords(s): Cardiovascular, Hematology, Therapeutics & Vaccines
Category(s): Therapeutics > Cardiovascular, Therapeutics > Hematology
A Novel Biomarker and Therapeutic Target for Atrial Fibrillation in Humans (UCLA Case No. 2024-041)
UCLA researchers at the Geffen School of Medicine have identified a novel biomarker and therapeutic target for early diagnosis and treatment of post-operative atrial fibrillation. BACKGROUND: Post-operative atrial fibrillation (POAF) is a common complication following cardiac surgery, affecting 30-50% of patients. Patients who develop POAF have an...
Published: 3/26/2026   |   Updated: 3/26/2026   |   Inventor(s): Thomas Vondriska, Matthew Fischer
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular
Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)
UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...
Published: 2/26/2026   |   Updated: 2/5/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology
Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)
UCLA researchers from the Department of Medicine have discovered a novel therapeutic target to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. BACKGROUND: Heart failure is one of the leading causes of death and disease with over 500,000 cases diagnosed each year in...
Published: 2/26/2026   |   Updated: 2/5/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology
Automatic Segmentation and Registration of the Cardiac Myocardium for Targeted Localization of Cardiac Arrhythmias in Radiotherapy (UCLA Case No. 2021-274)
UCLA researchers from the department of Radiation Oncology have developed a novel artificial intelligence (AI) method to automatically generate a contour model from image data of patients with cardiac arrythmias for the improvement of stereotactic body radiation therapy (SBRT). Related Papers (from the inventors only): Morris E, Chin R, Wu T, Smith...
Published: 1/23/2026   |   Updated: 1/23/2026   |   Inventor(s): Minsong Cao, Dan Ruan
Keywords(s):  
Category(s): Medical Devices > Medical Imaging, Therapeutics > Cardiovascular
Histone H1 as a Therapeutic Target for Fibrosis (UCLA Case No. 2023-148)
UCLA researchers from the David Geffen School of Medicine have identified linker histone H1 as a critical regulator of pathologic gene expression and cellular mechanics, establishing its potential role as a therapeutic target for the treatment of fibrosis. BACKGROUND: Heart failure affects ~6 million Americans and has a 5-year survival rate of ~50%...
Published: 10/29/2025   |   Updated: 10/29/2025   |   Inventor(s): Thomas Vondriska
Keywords(s):  
Category(s): Therapeutics > Cardiovascular
Brain Repair in Vascular Dementia and Stroke with A3AR (UCLA Case No. 2024-220)
UCLA researchers from the Department of Neurology have discovered and validated intercellular signaling pathways that can be therapeutically targeted to drive repair and functional recovery in vascular dementia. BACKGROUND: Vascular dementia (VaD) is the second leading cause of dementia and is driven by ischemic injury to cerebral white matter, producing...
Published: 10/14/2025   |   Updated: 10/14/2025   |   Inventor(s): Stanley Carmichael
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular, Life Science Research Tools > Animal Models
A Nanoengineered Immunosensor to Detect Multiple Circulating Biomarkers for Rapid Prediction of Acute Thrombosis (UCLA Case No. 2025-015)
UCLA researchers in the Department of Cardiology have developed a nanoengineered immune sensor that uses machine learning to detect multiple circulating biomarkers for rapid, accurate prediction of acute thrombosis. BACKGROUND: Acute thrombosis represents a significant contributor to both acute and chronic illnesses. Moreover, the correlation between...
Published: 11/25/2025   |   Updated: 9/24/2025   |   Inventor(s): Tzung Hsiai
Keywords(s):  
Category(s): Materials > Nanotechnology, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular, Diagnostic Markers > Targets And Assays, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Artificial Intelligence & Machine Learning
Treatment for the Rare and Fatal Disease Calciphylaxis (UCLA Case No. 2026-010)
Contact UCLA Technology Development Group to learn more.
Published: 9/19/2025   |   Updated: 9/19/2025   |   Inventor(s): Arjun Deb
Keywords(s):  
Category(s): Therapeutics > Cardiovascular
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