Search Results - therapeutics+%3e+cardiovascular

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Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)
UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...
Published: 2/26/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology
Coagulation Factor XI (FXI) Functional Roles and Regulation for Treatment of Heart Failure (UCLA Case No. 2022-141)
UCLA researchers from the Department of Medicine have discovered a novel therapeutic target to treat heart failure with preserved ejection fraction (HFpEF), which afflicts approximately half of all patients with heart failure. BACKGROUND: Heart failure is one of the leading causes of death and disease with over 500,000 cases diagnosed each year in...
Published: 2/26/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Metabolism And Endocrinology
Automatic Segmentation and Registration of the Cardiac Myocardium for Targeted Localization of Cardiac Arrhythmias in Radiotherapy (UCLA Case No. 2021-274)
UCLA researchers from the department of Radiation Oncology have developed a novel artificial intelligence (AI) method to automatically generate a contour model from image data of patients with cardiac arrythmias for the improvement of stereotactic body radiation therapy (SBRT). Related Papers (from the inventors only): Morris E, Chin R, Wu T, Smith...
Published: 1/23/2026   |   Inventor(s): Minsong Cao, Dan Ruan
Keywords(s):  
Category(s): Medical Devices > Medical Imaging, Therapeutics > Cardiovascular
Histone H1 as a Therapeutic Target for Fibrosis (UCLA Case No. 2023-148)
UCLA researchers from the David Geffen School of Medicine have identified linker histone H1 as a critical regulator of pathologic gene expression and cellular mechanics, establishing its potential role as a therapeutic target for the treatment of fibrosis. BACKGROUND: Heart failure affects ~6 million Americans and has a 5-year survival rate of ~50%...
Published: 10/29/2025   |   Inventor(s): Thomas Vondriska
Keywords(s):  
Category(s): Therapeutics > Cardiovascular
Brain Repair in Vascular Dementia and Stroke with A3AR (UCLA Case No. 2024-220)
UCLA researchers from the Department of Neurology have discovered and validated intercellular signaling pathways that can be therapeutically targeted to drive repair and functional recovery in vascular dementia. BACKGROUND: Vascular dementia (VaD) is the second leading cause of dementia and is driven by ischemic injury to cerebral white matter, producing...
Published: 10/14/2025   |   Inventor(s): Stanley Carmichael
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular, Life Science Research Tools > Animal Models
A Nanoengineered Immunosensor to Detect Multiple Circulating Biomarkers for Rapid Prediction of Acute Thrombosis (UCLA Case No. 2025-015)
UCLA researchers in the Department of Cardiology have developed a nanoengineered immune sensor that uses machine learning to detect multiple circulating biomarkers for rapid, accurate prediction of acute thrombosis. BACKGROUND: Acute thrombosis represents a significant contributor to both acute and chronic illnesses. Moreover, the correlation between...
Published: 11/25/2025   |   Inventor(s): Tzung Hsiai
Keywords(s):  
Category(s): Materials > Nanotechnology, Platforms > Diagnostic Platform Technologies, Therapeutics > Cardiovascular, Diagnostic Markers > Targets And Assays, Medical Devices > Monitoring And Recording Systems, Software & Algorithms > Artificial Intelligence & Machine Learning
Treatment for the Rare and Fatal Disease Calciphylaxis (UCLA Case No. 2026-010)
Contact UCLA Technology Development Group to learn more.
Published: 9/19/2025   |   Inventor(s): Arjun Deb
Keywords(s):  
Category(s): Therapeutics > Cardiovascular
INSPIROMARK (Case No. 2025-293)
Summary: UCLA researchers have developed InspiroMark, a standardized, implantable imaging marker designed to enhance the efficiency, reliability and ease of grafted vessel localization following coronary artery bypass graft (CABG). Background: Coronary Artery Bypass Graft (CABG) surgery is a common procedure used to restore blood flow to the heart....
Published: 2/9/2026   |   Inventor(s): Sneha Shaha, Michael Malig, Sukhneet Dhillon
Keywords(s):  
Category(s): Diagnostic Markers, Medical Devices, Medical Devices > Cardiac, Medical Devices > Medical Imaging > CT, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging > X-Ray, Medical Devices > Medical Imaging > Fluorescence, Medical Devices > Monitoring And Recording Systems, Medical Devices > Surgical Tools, Therapeutics > Cardiovascular, Therapeutics > Radiology, Therapeutics > Transplant
Method and Apparatus for Segmentation of Dense MR Images Using Deep Learning with Domain Adaptation (Case No. 2025-208)
Summary: UCLA researchers from the Department of Radiological Sciences have developed a deep learning-based segmentation framework that enables fully automated and reproducible analysis of left ventricular (LV) function in Displacement Encoding with Stimulated Echoes (DENSE) MRI. Background: Myocardial strain is a key metric for analyzing how much...
Published: 10/17/2025   |   Inventor(s): Xiaodong Zhong, Siyue Li, Kim-Lien Nguyen
Keywords(s): acute myocardial infarction, adjustable mount, aneurysm drainage, automatic leveling, bedside decisions, blood pressure monitoring, cardiac cycle, Cardiac Electrophysiology, Cardiac failure, Cardiac Magnetic Resonance Imaging, Cardiac MRI, Cardiovascular, Cardiovascular Disease, Cardiovascular Disease Nephropathy, cardiovascular diseases, cardiovascular monitoring, cerebrospinal fluid (CSF) drainage, Cine MRI, clamp, critical-care, CSF drainage, Deep learning MRI, DENSE MRI, laser alignment, Left ventricular segmentation, lumbar drains, Motion analysis, MRI, multiparametric MRI (mpMRI), Myocardial strain, non-invasive cardiac monitoring, operator variability, passive reflective target, phlebostatic axis measurement, Pseudo-labeling, radial MRI, Segment Anything Model (SAM), self-leveling system, transducer alignment, Unsupervised domain adaptation (UDA)
Category(s): Medical Devices > Cardiac, Electrical > Imaging, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Medical Imaging > MRI, Medical Devices > Medical Imaging
Targeting the Bile Acid Pathway to Treat Cardiometabolic Disease (UCLA Case No. 2024-146)
UCLA researchers from the Department of Medicine and Division of Cardiology have identified target enzymes involved in bile acid synthesis and developed methods to improve disease outcomes in fatty liver and atherosclerosis. BACKGROUND: Dietary fat is an essential, energy-dense nutrient necessary for survival. To support this, the intestinal system...
Published: 7/17/2025   |   Inventor(s): Thomas Vallim
Keywords(s):  
Category(s): Life Science Research Tools > Screening Libraries, Therapeutics > Gastroenterology, Therapeutics > Metabolism And Endocrinology, Life Science Research Tools > Research Methods, Therapeutics > Cardiovascular
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