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Novel Kinase Inhibitory Thiazines
Summary
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including:
Oncogenic gene fusion DNAJB1-PRKACA (PKADJ)
Wild type protein kinase A (PKA)
Protein kinase...
Published: 3/14/2025
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Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases
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Reverse Thiazine Kinase Inhibitors
Summary
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including:
Oncogenic gene fusion DNAJB1-PRKACA (PKADJ)
Wild type protein kinase A (PKA)
Protein kinase...
Published: 3/14/2025
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Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases
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Novel Kinase Inhibitory Aplithianines
Summary
The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a class of novel aplithianine-derived small molecule analogs that compete with ATP for binding on a range of clinically relevant kinases including:
Oncogenic gene fusion DNAJB1-PRKACA (PKADJ)
Wild type protein kinase A (PKA)
Protein kinase...
Published: 3/14/2025
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Inventor(s): Barry O'Keefe, Lin Du, Brice Wilson, Ping Zhang, William Moore, Dongdong Wang, Juliana Martinez Fiesco, Ning Li
Keywords(s):
Category(s): Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare/Neglected Diseases
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Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines
CDC researchers have developed a potent immunogenic enhancer polypeptide useful for improving flavivirus vaccines. Flaviviruses such as dengue virus (1, 2, 3 and 4), Japanese encephalitis virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, yellow fever virus and tick-borne encephalitis virus are a great burden on public health. ...
Published: 10/28/2024
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Inventor(s): Holly Hughes, Gwong-Jen Chang
Keywords(s): ADJUSTMENT, adjuvant, Adjuvant-like, BCXXXX, Boost, BOOSTING, CD4, CDC Docket Import, CDC Docket Import CDC Prosecuting, Cell, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DENGUE, DENGUE FEVER, Dengue Vaccine, Dengue-1, Dengue-2, Dengue-Like, DXXXXX, Epitope, Flavivirus, FLAVIVIRUSES, Identification, in vivo, JAPANESE ENCEPHALITIS VIRUS, Listed LPM Houze as of 4/15/2015, Mosquito, Mosquitoes, Nile, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMER, T, THEREOF, Tick-Bone, TICK-BORNE, UBXXXX, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, Vector-borne, Vector-borne diseases, virus, VLXXXX, VOXXXX, WAXXXX, West, WIXXXX, WJXXXX, WMXXXX, XCXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, Application > Research Materials, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare/Neglected Diseases
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Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests
In nature, some beetle larvae possess specialized barbed hastate setae that serve as an entanglement defense mechanism and incapacitate other insects. CDC researchers have developed synthetic setae for control and entrapment of insects and other pests. While smaller synthetic setae can trap mosquitoes and small insects, larger “macro” setae can be...
Published: 10/28/2024
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Inventor(s): Robert Wirtz
Keywords(s): AE2BXX, AE2XXX, AEXXXX, AFXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, CONTROL, DB2XXX, DB4XXX, DBXXXX, DEVICE, Devices, DEXXXX, DXXXXX, Entangling, Entrapment, insect, Insects, Mosquito, Mosquitoes, Net, Pest, Pests, population sampling, PXXXXX, Setae, TRAP, UBXXXX, UXXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YFXXXX, Zoo
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, Application > Research Materials, Application > Occupational Safety and Health, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare/Neglected Diseases
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Multiplex Assay for Detection of Dengue Virus
Dengue virus (DENV) is the cause of dengue illness (dengue fever, dengue hemorrhagic fever, and dengue shock syndrome). CDC researchers have developed a RT-PCR multiplex assay that, prior to sero-conversion, selectively detects dengue virus in biological or other fluid media, such as whole blood, plasma, or serum. The primers and probes from this assay...
Published: 10/28/2024
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Inventor(s): Edgardo Vergne, Gilberto Santiago, Jorge Munoz-Jordan
Keywords(s): Broad, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, DXXXXX, Serotypes, UB1XXX, virus
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare/Neglected Diseases
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Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever
Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...
Published: 10/28/2024
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Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger
Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare/Neglected Diseases
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Safer Attenuated Virus Vaccines with Missing or Diminished Latency of Infection
This technology describes recombinant viruses that have weakened ability to establish and/or maintain latency and their use as live vaccines. The viruses have one or more genetic mutations that allow for continued replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the virus that causes...
Published: 10/28/2024
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Inventor(s): Lesley Pesnicak, Edward Cox, Jeffrey Cohen
Keywords(s): BUT, chickenpox, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Impaired, Latency, MUTANT, Patent Category - Biotechnology, REPLICATION, UAXXXX, Vaccine, VARICELLA-ZOSTER
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, TherapeuticArea > Rare/Neglected Diseases
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Parvovirus B19 Vaccine
Parvovirus B19 (B19V) infection causes fifth disease, a disease characterized by rashes to the face and other parts of the body that primarily affects children. However, adults can also develop fifth disease and it can lead to more severe conditions. Patients that are immunocompromised, such as those who are HIV infected, organ transplant recipients,...
Published: 10/28/2024
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Inventor(s): Neal Young, Sachiko Kajigaya, Takashi Shimada, Ning Zhi
Keywords(s): Admin Lic Spec Review Mar-09 Active Determina, AgainstB19V, B19, B19V, BBXXXX, CAPSID, Capsids, CODON, CRADA, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, diagnostic, DNA-based, DXXXXX, GENES, Infection, Non-pennissive, PARTICLE, PARVOVIRUS, Patent Category - Biotechnology, SACGHS DNA Patent Initial Set, UA1XXX, VACCCINE, vaccines, VIRUS-LIKE, VLP-and
Category(s): Collaboration Sought > Collaboration, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, TherapeuticArea > Rare/Neglected Diseases
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Cyclodextrins as Therapeutics for Lysosomal Storage Disorders
Cyclodextrins (CD), alone or in combination with other agents (e.g., vitamin E), as therapeutics for the treatment of lysosomal storage disorders (LSDs) caused by the accumulation of non-cholesterol lipids.
CDs are sugar molecules in a ring form. The alpha-CD (6 sugars), beta-CD (7 sugars) and gamma-CD (8 sugars) are commonly used cyclodextrins. The...
Published: 10/28/2024
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Inventor(s): Wei Zheng, Miao Xu, Manju Swaroop, Juan Marugan, John McKew
Keywords(s): Combination, CYCLODEXTRIN, DISEASES, e, IB6XXX, IBXXXX, IXXXXX, Lysosomal, NB1JXX, NB1XXX, NBXXXX, NXXXXX, Storage, treatment, UA1XXX, USES, Vitamin
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, Application > Therapeutics, TherapeuticArea > Neurology, TherapeuticArea > Reproductive Health, TherapeuticArea > Rare/Neglected Diseases
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