Search Results - therapeuticarea+%3e+immunology

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Fluorinated MU-Opioid Receptor Agonists
Summary: Investigators at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they come...
Published: 12/20/2024   |   Inventor(s): Michael Michaelides, Juan Gomez, Kenner Rice, Agnieszka Sulima, Michael Baumann
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Radiology, Collaboration Sought > Licensing
A Fundamental Tool for Efficient Recovery of RNA Viruses through Reverse Genetics
BSR T7/5 cells represent a foundational advancement in virology, offering a robust platform for the recovery of RNA viruses via reverse genetics. Established over 20 years ago, these cells have proven instrumental in the recovery of a wide array of RNA viruses, particularly those belonging to the mononegavirales order. By enabling the insertion of antigenome...
Published: 12/10/2024   |   Inventor(s): Ursula Buchholz
Keywords(s):  
Category(s): Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Bispecific Antibody Targeting Anthrax Toxins and Capsule for Enhanced Biodefense
The technology focuses on the development of a tetravalent bispecific antibody effective against Bacillus anthracis, the bacterium responsible for anthrax. This antibody combines the specificities of two monoclonal antibodies (mAbs): one targeting anthrax protective antigen (PA) and the other targeting the bacterial capsule. The anti-PA mAb shows potent...
Published: 12/10/2024   |   Inventor(s): Zhao Chun Chen, Robert Purcell, Mahtab Moayeri, Stephen Leppla
Keywords(s):  
Category(s): Application > Therapeutics, Application > Vaccines, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Transgenic Mouse Models for Studying HLA-B57:01 and HLA-B15:02 Linked Immune Responses and Hypersensitivity Reactions
Transgenic mouse models expressing human HLA-B57:01 and HLA-B15:02 molecules have emerged as invaluable tools for unraveling the intricacies of immune responses and hypersensitivity reactions. The major histocompatibility complex (MHC) encoded proteins play a pivotal role in the immune system by presenting peptide fragments to T lymphocytes, and HLA-B57:01...
Published: 12/10/2024   |   Inventor(s): David Margulies, Kannan Natarajan, Mulualem Tilahun, Michael Norcross, Lisa Boyd
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Animal Models, ResearchProducts > Research Equipment, TherapeuticArea > Immunology
Characterization and Comparison of LAD2 and LADR Mast Cell Lines: Insights into Mastocytosis and HIV Infection
LAD2 and LADR cell lines are invaluable tools in mast cell research, offering insights into mastocytosis and immune responses. Derived from CD34+ cells, LAD2 cells have been extensively used for over 18 years, while LADR cells, a newer variant, exhibit enhanced characteristics such as larger size, increased granulation, and faster doubling time. Both...
Published: 12/10/2024   |   Inventor(s): Arnold Kirshenbaum, Dean Metcalfe
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Human Cell Lines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Fully Human Chimeric Antigen Receptors Against CD276 for the Treatment of Solid Tumors
Summary: The National Cancer Institute (NCI) seeks research co-development partners and licensees for a panel of five fully human antibodies against CD276 for the treatment of solid tumors. The collection also includes human CARs incorporating the antibodies for immunotherapeutic use. Description of Technology: Chimeric antigen receptor (CAR)-T...
Published: 12/20/2024   |   Inventor(s): Brad St. Croix, Pradip Bajgain, Yang Feng
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing
Methods of Detecting Loss of Heterozygosity and Damaging Mutations in Immune-Related Genes Using Liquid Biopsies
Summary: The National Cancer Institute (NCI) seeks co-development partners and/or licensees for a liquid biopsy diagnostic assay capable of detecting loss of heterozygosity (LOH) and somatic mutations in genes important for antigen processing and presentation and interferon-γ response pathways. Description of Technology: Immunotherapy is...
Published: 12/9/2024   |   Inventor(s): Scott Norberg, Andrew Sinkoe, Xiaolin Wu, James Gulley
Keywords(s):  
Category(s): Application > Diagnostics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology
Degrader Molecules for hRpn13Pru, PCLAF, RRM2 and Other KEN Box-containing Proteins
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for three small molecules that target hRpn13, an overexpressed protein in certain cancers. Description of Technology: Over 35,000 new cases of multiple myeloma are diagnosed each year in the US. Standard of care and experimental therapies include...
Published: 12/20/2024   |   Inventor(s): Kylie Walters, Xiuxiu Lu
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Immunology, Collaboration Sought > Licensing
Tixocortol for the Prevention or Treatment of SARS-CoV-2 and Other Coronaviruses
Summary: The National Cancer Institute (NCI) seeks collaborators and/or licensees for co-development and commercialization of an inhibitor of coronavirus main protease. Description of Technology: The recent COVID-19 pandemic led to millions of deaths worldwide – presenting an urgent need to develop vaccines and therapeutics against SARS-CoV-2...
Published: 12/20/2024   |   Inventor(s): David Davis, Robert Yarchoan, Brett Eaton, Richard Gussio, Brian Peyser, Tam Nguyen, Ashwin Nair, Yana Astter
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology, Collaboration Sought > Licensing
Immunotherapy Delivery System to Improve Organ Transplantation Outcomes
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a delivery system to improve transplant outcomes through inhibition of the JAK/STAT pathway. Description of Technology: Value Proposition • Novel Therapy: Hydro(LNp), is a new therapeutic application to improve outcomes for organ...
Published: 12/6/2024   |   Inventor(s): Giorgio Raimondi, Joel Schneider, Julia Patrone, Alexander Komin, Monessha Nambiar, Xiomara Calderon-Colon, Olivia Tiburzi
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Cardiology, TherapeuticArea > Nephrology
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