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Therapeutic Peptide ND-13 to Prevent Injury from Chronic Kidney Disease
­GW and Tel Aviv University researchers developed a small peptide, ND-13, for treatment of chronic kidney disease (CKD). The only current treatment of CKD and end-stage renal disease is renal replacement therapy via dialysis or kidney transplantation. There remains a need to provide alternative therapies for treating kidney disorders. ND-13 contains...
Published: 7/30/2024   |   Inventor(s): Santiago Gonzalez, Pedro Jose, Daniel Offen, Rolando Eisen
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Proteins and Peptides
Immunotherapies Targeting SSX2 Peptide Displayed by MHC on Tumors
­Chimeric Antigen Receptor (CAR) T cells are making headlines with their recent FDA approvals and ability to eradicate cancers. Most CAR T therapies target tumor cells via a tumor associated antigen (TAA). Unfortunately, TAAs are also expressed on non-cancerous tissues, leading to significant risk for patients. SSX2 protein expression is restricted...
Published: 7/30/2024   |   Inventor(s): Eric Yvon, Catherine Bollard, Stacey Van Pelt, Scott Raskin, Gerhard Held, Christine Sturm, Michael Pfreundschuh
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Proteins and Peptides
Optimization of Cold Atmospheric Plasma-Stimulated Media for Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP) while leaving neighboring normal cells intact. In a subsequent study, the researchers showed that similar anti-cancer effects can be achieved indirectly using CAP-stimulated media (CAPSM). Stability of CAPSM (preservation of its anti-cancer...
Published: 7/30/2024   |   Inventor(s): Dayun Yan, Michael Keidar, Jonathan Sherman
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics
Intranasal Oxytocin Therapy for Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a health risk that occurs in 24% of males and 9% of females in the United States. OSA can lead to several cardiovascular diseases including hypertension, arrhythmia, and stroke. Continuous positive airway pressure (CPAP) treatments often fail due to low compliance. GW Researchers developed an intranasal oxytocin administration...
Published: 7/30/2024   |   Inventor(s): David Mendelowitz, Heather Jameson, Vivek Jain, Jay Kimbro
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Category(s): Technology Classifications > Medical Devices > Cardiology, Technology Classifications > Therapeutics > Proteins and Peptides
Thinking outside the heart: Use of engineered cardiac tissue for treatment of chronic deep venous insufficiency
­Researchers at George Washington University invented a new organ that can return blood flow to veins lacking functioning valves. The organ is a rhythmic cuff made of cardiac muscle cells that surrounds the vein. The cuff acts as a “mini heart” to aid blood flow through the venous segments. It can be made of a patient’s own adult...
Published: 9/11/2024   |   Inventor(s): Narine Sarvazyan
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides