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Nanoparticles for Uniform Nanowarming of Cryopreserved Organs
Enhances Organ Transplant Viability by Rewarming Without Damaging Temperature Gradients These nanoparticles leverage biocompatible coating and exceptional aggregation resistance to permeate organs for cryopreservation and nanowarming. Organ transplants deliver lifesaving care to tens of thousands of Americans each year, but the demand for transplants...
Published: 8/27/2024   |   Inventor(s): Carlos Rinaldi, Andreina Chiu Lam
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others
Broad Spectrum Antimicrobial Compounds for Countering Antibiotic-Resistant Bacteria
Provide a Number of Promising Starting Points for Developing New Classes of Antibiotics These molecular compounds have potent antibacterial activity against a broad spectrum of Gram-negative bacteria, have no structural similarity to known antibiotics, can be readily synthesized in a few steps, and have low cytotoxicity with mammalian cells. Antibiotic...
Published: 9/4/2024   |   Inventor(s): Timothy Spicer, Louis Scampavia
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
3D-Printed Extracellular Vesicles (EVs) for DNA/RNA Sequencing
Enables Single Vesicle DNA/RNA Sequencing to Differentiate Sub-Populations of Extracellular Vesicles (EVs) These 3D-printed extracellular vesicle (EV) droplets enable DNA and RNA sequencing to differentiate extracellular vesicle subpopulations. Extracellular vesicles are nanosized vesicles containing a variety of cargo, including mRNA, proteins, and...
Published: 9/4/2024   |   Inventor(s): Thomas Schmittgen, Thomas Angelini, Andrew Brock, Jinmai Jiang, Senthilkumar Duraivel
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Diagnostics
Phenotypic High-Throughput Screening Assay for Identifying Brain-Derived Neurotrophic Factor (BDNF)-Enhancing Compounds
Identifies Potential Therapeutic Compounds to Treat BDNF- Related Neurological Diseases This phenotypic high-throughput screening (HTS) assay identifies potential therapeutic compounds for treating brain-derived neurotrophic factor (BDNF)-related neurological disorders. Brain-derived neurotrophic factor (BDNF)is a secreted growth factor that binds...
Published: 9/3/2024   |   Inventor(s): Baoji Xu, Guey-Ying Liao
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
Helmet-Removal Device to Limit Spinal Manipulation
Enlarges Helmet Opening, Aiding in the Safe Removal of a Helmet from an Injured Patient Without Jarring the Spinal Column This device facilitates the safe removal of a helmet from a trauma patient without jarring the wearer’s spinal column. In various sports and activities, including football, motorcycling, F-1, and NASCAR, participants may wear...
Published: 9/3/2024   |   Inventor(s): Martin Rosenthal
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others, Technology Classifications > Medical Devices > Equipment
Potent Anti-Viral Agent for Treating Herpes Simplex Virus (HSV) and SARS-CoV-2
Targets DNA and RNA Viruses without Host Cell Cytotoxicity This small therapeutic molecule treats DNA and RNA virus infections, including the herpes simplex virus (HSV) and SARS-CoV-2, with limited host cell cytotoxicity. The herpes simplex virus type 1 (HSV-1) is common and presents in approximately 90% of the population worldwide. While the clinical...
Published: 9/3/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
Rapid Diagnostic Test for Detecting Bacterial Infections
Uses Nucleic Acid Amplification to Accurately Detect Virtually All Bacterial Species in Clinical Samples This rapid PCR-based test uses nucleic acid amplification to quickly and accurately detect harmful bacteria from blood samples without producing false positives. Bloodstream infections (BSI) are among the most severe manifestations of bacterial...
Published: 1/30/2024   |   Inventor(s): Kenneth Rand, Herbert Houck
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Others, Technology Classifications > Human Health Care, Technology Classifications > Human Health Care > Diagnostics
Inhibition of a Cholesterol Metabolism Gene for Effectively Treating Sepsis
Pharmacologically Blocking Specific Cholesterol Gene to Treat and Reduce Early Death from Sepsis This cholesterol metabolism gene is upregulated in sepsis patients with poor prognoses, and its inhibition shows promise as an effective treatment. Sepsis is the body’s extreme immune response to an existing infection, giving rise to an enhanced chain...
Published: 1/22/2024   |   Inventor(s): Faheem Guirgis, Vinitha Jacob, Jordan Shavit, Srinivasa Reddy
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Therapeutics, Technology Classifications > Human Health Care > Others
Mixed-Reality Medical Imaging System for Patient Alignment in Radiation Oncology
Orients and Aligns a Patient with a Medical Device for Optimal and Precise Delivery of Radiation Therapy Safe and effective radiotherapy (RT) requires the reproduction of a specific patient posture and the precise alignment of the patient with an RT device. Any difference in these two aspects can lead to under-dosing the tumor or overdosing healthy...
Published: 2/6/2024   |   Inventor(s): Perry Johnson
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Others
Adaptive Olfactory Measure of Threshold (ArOMa-T) an Olfactory Dysfunction Test
Evaluates an Individual's Sense of Smell Using a Novel Adaptive Algorithm Paired with a Card-Based Tool to Determine Odor Detection Thresholds This odor detection threshold test pairs a novel adaptive algorithm with a card-based tool to rapidly determine an individual’s odor detection threshold. Potential uses include: (1) assessing changes...
Published: 2/27/2024   |   Inventor(s): Steven Munger
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Human Health Care > Others
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