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Connecting multiple tRNA molecules, including in vitro transcribed as well as native tRNAs, to enable sequencing and structural applications Background: Transfer RNA (tRNA) molecules play a crucial role in biological processes, but technical limitations hinder their analysis. The short length of individual tRNAs makes them challenging to sequence...

Published: 6/13/2025 | Inventor(s): Miten Jain, Stuart Akeson, Hugh Olsen, Robin AbuShumays, Nicolette Thomas, Mark Akeson

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Bioinformatics, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

Method for using Reduced-Order Dynamics for Protective Equipment design

Method for using reduced-order dynamics for protective equipment design Background: The development of protective equipment, particularly helmets, requires extensive simulation and optimization to minimize injury risks. Traditional computational methods rely on high-fidelity simulations that demand significant computational resources, making iterative...

Published: 6/13/2025 | Inventor(s): Sinan Muftu, Rouzbeh Amini, Turner Jennings

Keywords(s):

Category(s): Technology Classifications > 3. Computer Science > Software, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

Ease-of-manufacture Highly Transparent Thin Polyvinyl Alcohol Aerogel

Energy-efficient and cost-effective method for manufacturing transparent and robust PVA aerogels for green energy applications Background: Aerogels, particularly silica-based variants, have been widely used for their exceptional thermal insulation and transparency. However, their fragility has posed significant challenges for broader applications,...

Published: 6/13/2025 | Inventor(s): Yi Zheng, Xiaoli Li

Keywords(s):

Category(s): Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 2. Physical Science > Environmental/Clean tech

Programming cellular condensates for living materials using an intrinsically disordered protein display platform

Pioneering self-organizing living materials with dynamic reconfiguration capabilities Background: Cell surface display technology, which utilizes genetic engineering to modify proteins on cellular surfaces, has been instrumental in various biotechnology applications, including enzyme engineering and vaccine development. However, current cell surface...

Published: 6/13/2025 | Inventor(s): Neel Joshi, Rong Chang

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 2. Physical Science > Advanced materials/Nanomaterials

GlycoFix-3 (Structurally and Functionally Repaired Endothelial Glycocalyx, 3rd Edition)

GlycoFix-2 is a chemical formulation that repairs blood vessel linings to prevent heart diseasesGlycoFix-2: Chemical Repair of Blood Vessel Linings for Heart Disease PreventionBackground The endothelial glycocalyx is a sugar mesh coat that serves as a protective barrier for endothelial cells, such as blood vessels. The endothelial glycocalyx can...

Published: 1/3/2025 | Inventor(s): Eno Ebong, Solomon Mensah, Ronodeep Mitra

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Discovery, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

Mitochondria transplantation in immune effector cells using droplet microfluidics and a sorter device for activating, modulating, or inhibiting immune cell activity or any cancer or tissue cell type

Search Result Description Here Copy Image URL via instructions below Copy Image URL via instructions below INV-23048 Background: Mitochondria are intracellular organelles that power cells by maintaining cellular homeostasis and contributing to vital cellular functions. They play an instrumental role in immune cell maintenance by...

Published: 2/3/2025 | Inventor(s): Tania Konry, Judene Thomas, Agustin De Ganzó

Keywords(s):

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology

DNA-based method for rapid capture, detection and analysis of viruses on surfaces

A sensitive and rapid alternative to current viral detection methods INV-21083 Background Thousands of deaths are occurring yearly due to various viral infectious diseases, which has resulted in global public health crisis. COVID‑19 has further brought into focus, the critical need for early detection to prevent transmission, apply effective...

Published: 10/15/2024 | Inventor(s): Sara Rouhanifard

Keywords(s): Bio-imaging, COVID-19, Diagnostic tool, virus

Category(s): Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Diagnostics

Site-specific Modification of Antibody through a Tranglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan

Site-specific Modification of Antibody through a Transglutaminase-mediated Conjugation of Glutamine While Maintaining the Core Glycan Technical advancement of site-specific antibody engineering creating more homogenous biologics Institute Reference: INV-21035 Background Antibodies are a predominant class of macromolecules with wide-spread...

Published: 1/24/2025 | Inventor(s): Zhaohui Zhou, Amissi Sadiki

Keywords(s): Antibody conjugates, Endoglycosidase, Glycan remodeling, Glycoengineering, Transglutaminase

A benchtop platform to rapidly produce nanofibrous materials

INV-21085 Background Nanofibrous scaffolds can mimic the mechanical and structural properties of the natural extracellular matrix (ECM) and tissues (e.g., collagenous tissues), thereby demonstrating high potential in tissue engineering and regenerative medicine. However, the rapid and reproducible fabrication of biomimetic scaffolds for tissue engineering...

Published: 6/4/2025 | Inventor(s): Cassandra Martin, Leila Deravi, Jeffrey Paten

Keywords(s): biomaterial-based scaffold, Collagen, concentric cylinders, fibril alignment

Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering, Not in use > -Materials

Differentiation of Olfactory Mucosa Derived Mesenchymal Stem Cells to Schwann Cells for Peripheral Nerve Repair

rder-collapse: collapse; } INV-21115 Background Peripheral nerve injuries resulting from trauma can be severe and permanently debilitating. Nerve autografting is the current gold standard for the treatment of such injuries. However, after grafting, in approximately one-third of cases, incomplete recovery with poor restoration of function is observed....

Published: 9/10/2024 | Inventor(s): Ryan Koppes, Katelyn Neuman, Abigail Koppes, Aidan Kenny

Keywords(s): Biomedical implants, Cell Culture, Neurological Disease

Category(s): Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering

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