Search Results - technology+category+%3e+drug+delivery

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Portable Thermal Nitric Oxide Generation Technology

Novel chemical composition that enables pure NO gas release upon heat. Technology Summary This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric...

Published: 12/15/2025 | Inventor(s): James Bour, Shuxiao Li

Keywords(s):

Category(s): Technology Category, Technology Category > Medical Devices, Technology Category > Drug Delivery

Methods For The Prediction Of Drug Penetration and Exposure In The Human Brain

Description: A novel 9‑compartment physiologically based pharmacokinetic model was developed and fully validated for prediction of heterogeneous drug distribution and exposure in the human central nervous system (CNS) and brain tumors. The 9-compartment model accounts for the general anatomical structure and pathophysiology of the human CNS and brain...

Published: 11/21/2025 | Inventor(s): Jing Li, Seongho Kim, Charuka Wickramasinghe

Keywords(s):

Category(s): Technology Category > Life Science, Technology Category > Method, Technology Category > Drug Screening, Technology Category > Drug Delivery

Using Nanotechnology to Target Aggressive Cancers

A modified gold nanoparticle is used to target aggressive triple negative breast cancer and melanoma by inhibiting RAD6 which is overexpressed in aggressive and chemo resistant cancers. Technology Summary This technology utilizes gold nanoparticles (GNPs) conjugated with a small molecule inhibitor (SMI#9) designed to target RAD6, a protein overexpressed...

Published: 9/26/2025 | Inventor(s): Malathy Shekhar, Guangzhao Mao, Yanhua Zhang

Keywords(s): Breast Cancer, Driving Lifelong Health, Nanotechnology

Category(s): Technology Category > Therapeutics, Technology Category > Oncology, Technology Category > Nanomaterials, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Cancer, Technology Category > Women's Health

Generation of gp78 null mice

Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...

Published: 9/15/2025 | Inventor(s): Avraham Raz, Andrei Golovko

Keywords(s):

Category(s): Technology Category > Research tools, Technology Category > Oncology, Technology Category > Life Science, Technology Category > Genomics/Genetics, Technology Category > Drug Screening, Technology Category > Drug Delivery, Technology Category > Drug Discovery, Technology Category > Biomedical, Technology Category > Biotechnology, Technology Category > Biology, Technology Category > Animal models

Ruthenium-based caging of nitrile-containing enzyme inhibitors

Technology Summary: Novel synthesis methods for caging nitrile-containing bioactive molecules to a non-toxic ruthenium metal complex have been developed which enable light activated release of a cathespin K inhibitor. Numerous potent and selective cathepsin inhibitors are being developed as drug candidates. Cysteine cathepsins are involved in the pathophysiology...

Published: 9/15/2025 | Inventor(s): Jeremy Kodanko, Claudia Turro

Keywords(s): Cancer, Pharmaceuticals

Category(s): Technology Category > Physical Sciences, Technology Category > Other, Technology Category > Life Science, Technology Category > Drug Delivery, Technology Category > Chemicals