Portable Thermal Nitric Oxide Generation Technology

Novel chemical composition that enables pure NO gas release upon heat.

Technology Summary

This technology enables safe, efficient, and portable generation of medical-grade nitric oxide (NO) by thermally activating a bench-stable solid-state NO-releasing molecule embedded in a porous polymer matrix. FDA approved Inhaled nitric oxide therapy is currently limited to hospital settings to account for controlled delivery. This technology produces NO free of toxic NO2 contamination under ambient air, making it suitable for home, emergency, and remote healthcare applications.

Key Advantages

• High yield NO release density from 1g of material
• Safe chemistry that avoids volatile toxic nitrogen oxides like NO2.
• Stable storage with months-long shelf life under ambient conditions
• Power-efficient thermal activation via ohmic heating elements suitable for battery power
• Compact and lightweight form factor suitable for portable devices

Market Opportunities

• Facilitates portable, on-demand iNO therapy for home, emergency, and remote care for pulmonary and cardiovascular conditions.
• Eliminates bulky, chemical-dependent, and high-power commercial iNO delivery constraints
• Reduces safety risks associated with volatile or toxic NO precursor chemicals

Stage of Development

Proof-of-Concept

Patent Status

Patent Pending

References & Publications

2025 “On-Demand Nitric Oxide Generation via Thermal Decomposition of N-Trityl Dihydro-1,2-Oxazines” https://doi.org/10.1002/ange.202419113