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Enhancing Drug Bioavailability: Curcumin and Its Derivatives as Modulators of UGT2B17 and Intestinal Enzymes
Unmet Need: Inhibitor drugs of UGT2B17 that can be used for boosting bioavailability of its substrates. Since curcumin is a safe bioactive compound with potential health benefits, however, it has poor bioavailability, inventors have explored the use of curcumin as a bioavailability enhancer of other nutrients or drugs. They have developed an approach...
Published: 2/8/2024   |   Inventor(s): Bhagwat Prasad, Deepak Ahire, Siavosh Naji-Talakar, Dilip Kumar Singh, Namrata Bachhav
Keywords(s): Bioavailability booster, Curcumin, Intestinal metabolism, UGT2B17
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
Neutrophil-mediated Delivery of Nanocrystal Drugs Enhances Cancer Therapy
Unmet Need: Efficient drug delivery is crucial for successful cancer treatment The efficient delivery of anticancer agents into tumor microenvironments is critical for successful cancer treatment, requiring drug carriers to overcome the tumor vasculature barriers and possess high drug contents. Current limitations include the limited applications of...
Published: 12/6/2023   |   Inventor(s): Zhenjia Wang, Yujie Su
Keywords(s):  
Category(s): Technologies > Health & Well-being > Pharmaceutical
Hydrogen Sulfide Releasing Agents
Abstract Hydrogen sulfide (H2S) has demonstrated several essential critical care benefits when delivered properly in low doses. The current state of the art delivery systems rely on gaseous delivery of H2S to patients. WSU researchers have developed chemical agents that controllably decompose to release H2S and demonstrated their efficacy in biological...
Published: 8/22/2024   |   Inventor(s): Ming Xian, Hua Wang, Yu Zhao
Keywords(s): Chemistry
Category(s): Technologies > Health & Well-being > Chemistry, Technologies > Health & Well-being > Pharmaceutical
Gas-assisted dynamic co-extrusion
Unmet Need: Scalable and high-throughput fabrication of personalized medicines In order to avoid dosage errors and adverse drug reactions for people taking multiple medications for co-occurring diseases, personalized medicines was introduced. This offered treatment of a patient by manufacturing proper drugs at the appropriate dosage via additive manufacturing...
Published: 5/26/2023   |   Inventor(s): Kuen-Ren Chen
Keywords(s): 3D printing, Additive Manufacturing, drug, Pharmaceutical, Precision medicine
Category(s): Products, Technologies, Technologies > Health & Well-being > Medical Devices, Technologies > Health & Well-being > Pharmaceutical
Nasal Treatment for Overdoses
­ Unmet Need: Accidental Deaths due to Benzodiazepines, Opiates, and Combined Benzodiazepine/Opiate Overdoses are Epidemic The use of opiates combined with benzodiazepines is ever-increasing. A study evaluating the prescription patterns between 2002 and 2014 reported that the annual number of patients receiving benzodiazepines increased 31 percent...
Published: 4/28/2023   |   Inventor(s): John White, Travis Denton
Keywords(s):  
Category(s): Technologies > Health & Well-being > Addiction, Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Pharmaceutical
Neutrophil Apoptosis induced by Nanoparticles Improved the Therapies of Inflammatory Diseases
Unmet Need:Improved specific induction of neutrophil apoptosis through the use of nanoparticles to treat inflammatory diseases. Systemic inflammatory responses are a normal response to infections and tissue damage. However, when the expression of inflammatory cells is uncontrolled associated diseases occur. Through specific targeting of neutrophil...
Published: 4/28/2023   |   Inventor(s): Zhenjia Wang, Canyang Zhang
Keywords(s):  
Category(s): Technologies > Health & Well-being > Sustaining health, Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
Treatment of Neurological and Inflammatory Conditions with Probiotics
Title: Treatment of neurological and inflammatory conditions with probiotics Unmet Need: Treatment of Neuroinflammatory Conditions Neuroinflammatory conditions lead to several ailments, including Acute Disseminated Encephalomyelitis (ADEM), Acute Optic Neuritis (AON), Transverse Myelitis, Neuromyelitis Optica (NMO), and Multiple Sclerosis (MS)....
Published: 4/28/2023   |   Inventor(s): Jean-Baptiste Roullet, Javier Ochoa-Reparaz, K. Michael Gibson, Andrea Castillo
Keywords(s): Probiotics
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
One-step one-pot synthesis of aliphatic amine and nitriles
Unmet Need: Single-step synthesis of aliphatic amine and nitriles With a growing market of high-quality surfactant and emulsifiers, global demand for amine and nitriles is growing rapidly. Traditionally, aliphatic amine are synthesized in multi-step process that treat feeds of multiple components like alcohols, olefin, nitriles etc. Current synthesis...
Published: 4/28/2023   |   Inventor(s): Hafsa Karroum, Norbert Kruse, Viacheslav Iablokov
Keywords(s): Catalyst
Category(s): Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Chemistry
Methods and Compositions for Prevention and Treatment of Apicomplexan Infections
Unmet Need: Effective treatment options to combat Apicomplexan parasitic infectionsDiseases caused by apicomplexan parasites, such as cryptosporidiosis and malaria are among the most devastating to humans and their domestic animals. Ongoing discovery and development of new drugs to treat these diseases is a medical and veterinary imperative. For example,...
Published: 5/25/2023   |   Inventor(s): Roberta O'Connor, Eric Schmidt
Keywords(s): Animal Research, anti-parasitic drugs, Global Human and Animal Health, Natural products, Pharmaceutical, Therapeutics, Veterinary
Category(s): Technologies > Health & Well-being > Veterinary, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Biotechnology
Identification of Cats at a High Risk for Developing Chronic Kidney Disease
Unmet Need: Effective strategies to identify cats that will benefit from early intervention to prevent onset of CKDChronic Kidney Disease (CKD) is the most common metabolic disease of domesticated cats and a clinically important cause of mortality in aged domestic cats. Despite the high prevalence of kidney disease, the underlying reasons why some cats...
Published: 6/29/2023   |   Inventor(s): Nicolas Villarino, Liam Broughton-Neiswanger, Michael Court, Neal Burke
Keywords(s):  
Category(s): Technologies > Health & Well-being > Diagnostics, Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Veterinary
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