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Auristatin Tyramine Phosphate Prodrugs and Aminoquinoline Derivatives
The remarkable anticancer properties of dolastatin 10, isolated from the sea hare (sea slug) Dolabella auricularia, have led to interest in closely related derivatives (auristatins) suitable for clinical trials. Most recently, such auristatins have been linked to antibodies for delivery. In many indications, however, it would be desirable to deliver...
Published: 2/23/2023   |   Inventor(s): George (Bob) Pettit, Fiona Hogan, Steven Toms
Keywords(s): Therapeutics
Category(s): Cancer Therapeutics, Pharmaceuticals, Life Science (All LS Techs)