Search Results - shuai+zhao

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Identification of Smurf2 as an HIF-1α–Degrading E3 Ubiquitin Ligase
Overview In cancer, hypoxia-inducible factor-1 (HIF-1) signaling promotes vascularization, increasing oxygen supply and facilitating the survival of malignant cells. It is also involved in metabolism alteration, immune evasion, cell invasion, and metastasis. We have determined that SMAD-specific E3 ubiquitin protein ligase 2 (Smurf2) reduces the stability...
Published: 11/1/2022   |   Inventor(s): Wafik El-Deiry, Shuai Zhao
Keywords(s):  
Category(s): Therapy Targets
DNA Nanocaged Enzymes
Compartmentalization increases the overall activity and specificity of encapsulated enzymes by protecting the enzymes, maintaining a high concentration of enzymes and substrates, and promoting substrate channeling. While there have been artificial enzymatic particles that have been created using compartmentalization by virus-like proteins, liposomes,...
Published: 2/23/2023   |   Inventor(s): Jinglin Fu, Hao Yan, Neal Woodbury, Zhao Zhao
Keywords(s): Bioanalysis, Catalysis, Enzymes
Category(s): Advanced Materials/Nanotechnology, Bioanalytical Assays, Chemistries & Devices, Life Science (All LS Techs), Medical Diagnostics/Sensors