Search Results - robert+farese

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Use of Auranofin for Treatment of Neurodegenerative Disorders
­Competitive Advantages Potential treatment for Alzheimer’s, FTD, and other neurodegenerative disorders Results show that various factors including insulin lead to activation of aPKC and the NFkappa-B inflammatory pathway in brain neurons and glial cells Auranofin (AF) is an FDA approved drug for other uses, thus relatively easy to conduct...
Published: 1/25/2024   |   Inventor(s): Robert Farese, Mini Sajan
Keywords(s): Medical Pharmaceuticals, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
aPKC Inhibitor for Treatment of Diabetes and Neurodegenerative Diseases and Disorders
Competitive Advantages Reduces both hyperinsulinemia & AD pathology Blood-Brain Barrier permeable Bimolecular specific inhibitor Prevents neurodegeneration Summary Numerous conclusions obtained from clinical data indicate a link between insulin resistance and an increase in Alzheimer’s disease (AD) susceptibility. An overexpression...
Published: 8/25/2023   |   Inventor(s): Robert Farese, Mini Sajan, Margaret Higgs
Keywords(s):  
Category(s): Technology Classifications > Medical > Endocrinology, Technology Classifications > Medical
Treating an Atypical Protein Kinase C Enzyme Abnormality
Competitive Advantages Prevents development of the disease Diminishes the pre-existing presence of the disease Summary USF inventors have discovered 2-acetyl-1,3-cyclopentanedione (ACDP), which has the potential to prevent the development of, or reverse/diminish the pre-existing presence of these metabolic disorders. The technology is a novel,...
Published: 8/27/2023   |   Inventor(s): Mini Sajan, Robert Farese
Keywords(s):  
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical