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New, targeted lung cancer treatment with splicing-modifying antisense oligonucleotides
A lead splicing-modifying antisense oligonucleotide (AON) delivered to different mice models of lung cancer effectively reduces tumor growth in vivo. The lead AON could be applicable to the targeted treatment of lung adenocarcinoma, lung squamous cell carcinoma, breast, liver, prostate, colon, cervix and other tumor types displaying enhanced NUMB...
Published: 10/10/2024   |   Inventor(s): Juan Valcarcel, Jordi Hernandez Ribera, Elias Bechara
Keywords(s): Oncology, RNA Modulation Technologies, Spliceosome / Splicing
Category(s): Biotechnology, Drug Targets & Mechanisms, Therapeutics (Biologics & Compounds)