Search Results - pooyan+jamshidi+dermani

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One-Bead-Two-Compound Macrocyclic Library and Methods of Preparation and Use

Competitive Advantages Chemo diversity, enhanced conformational rigidity, and greater protease resistance Increased conformational constraint and binding affinity Proven method of drug discovery Summary Combinatorial chemistry serves as a powerful tool for ligand screening against potential protein and peptide targets. However, macrocyclic peptidomimetic...

Published: 2/9/2024 | Inventor(s): Jianfeng Cai, Yan Shi

Keywords(s):

Category(s): Technology Classifications > Cancer

Helical Sulfono-γ-AApeptide Antagonize β-Catenin Signaling

Competitive Advantages Potent, specific, and cell permeable to target intracellular PPIs High stability against enzymatic degradation More effective than other peptides at antagonizing Wnt/β-catenin signaling Summary Protein-protein interactions (PPIs) are vital to the survival of cancer cells and are therefore a good target for anti-cancer...

Published: 7/17/2023 | Inventor(s): Jianfeng Cai, Peng Sang, Yan Shi, Haitao Ji, Min Zhang

Keywords(s): Cancer, Cancer Treatment Leukemias, Cancer Treatment Lymphomas, Peptides, Therapeutics

Category(s): Technology Classifications > Cancer

Synthesize Effective Ensemble Based Dynamic Defenses to Adversarial Attacks

Reference #: 01490 The University of South Carolina is offering licensing opportunities for Synthesize Effective Ensemble Based Dynamic Defenses to Adversarial Attacks Background: A lot of learning-based AI techniques are very prone to adversarial attacks. However, these attacks are detectable and there are algorithms that can defend against adversarial...

Published: 2/13/2024 | Inventor(s): Biplav Srivastava, Jianhai Su, Ying Meng, Pooyan Jamshidi Dermani, Jason O'Kane

Keywords(s): Adversarial attacks, AI safety, Ensemble based defenses

Category(s): Software and Computing