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Therapeutic Neutrophils for Cardiovascular Disease

THE CHALLENGE Treating chronic inflammatory and cardiovascular diseases like atherosclerosis has proven difficult due to the lack of precision in current therapies. While these conditions are driven by complex immune responses, existing treatments rely heavily on broad, systemic anti-inflammatory drugs that often come with unwanted side effects and...

Published: 4/14/2025 | Inventor(s): Liwu Li, Shuo Geng

Keywords(s):

Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics

Neutrophil Subsets for the Treatment of Cancer

THE CHALLENGE Developing a cancer immunotherapy platform that can effectively and safely leverage the complex role of neutrophils—an abundant, yet highly variable, type of innate immune cell continues to prove challenging. Unlike current therapies that primarily target the adaptive immune system, an approach that must navigate the dual nature...

Published: 4/14/2025 | Inventor(s): Liwu Li, Yao Zhang

Keywords(s):

Category(s): Technology Classifications > Biomedical, Technology Classifications > Biotechnology, Technology Classifications > Pharmacology and Therapeutics

Programmed Innate Leukocytes as Potent Therapeutic Agents to Treat Atherosclerosis and Stroke

This invention discloses a novel strategy to reprogram either allogenic or heterologous peripheral blood neutrophils and/or monocytes with a selective compound in vitro, into a homeostatic state that is conducive for healing of coronary heart disease and/or stroke. Reprogrammed monocytes and/or neutrophils can be used through i.v. injection into human...

Published: 1/31/2024 | Inventor(s): Liwu Li, Shuo Geng, Yao Zhang

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Category(s): Technology Classifications > Biomedical

Enhanced Anti-Tumor Immune State

Challenge Similar to vaccines, traditional immunotherapies target specific epitopes of cancerous cells. While several immunotherapies offer several benefits over other alternatives, immunotherapies are not very effective because of several reasons. Given that microbes/cells have similar epitopes and that tumors mutate, therapy may not work in all cases...

Published: 1/31/2024 | Inventor(s): Liwu Li, Yao Zhang, Christina Lee

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Category(s): Technology Classifications > Biomedical

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 2/18/2025 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

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Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert

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Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources

All-Fiber Multicore Fiber Laser Devices

Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources