Search Results - life+sciences+%3e+biomaterials

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Sustainable high molecular weight copolymers using the Vandenberg catalyst
This technology creates high molecular weight copolymers from lactones and epoxides using the Vandenberg catalyst. The process produces versatile, biodegradable materials with unique thermal properties and potential applications in environmental and biomedical fields. Background Copolymerization of lactones and epoxides is a crucial area of research...
Published: 9/13/2024   |   Inventor(s): Nathaniel Lynd, Malgorzata Chwatko
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Biomaterials
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 9/10/2024   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials
Nanoscale, pH-responsive polycationic networks for targeted delivery of anionic biologic therapeutics
­This technology involves nanoscale, pH-responsive polycationic hydrogels for delivering anionic biologic therapeutics like siRNA. These hydrogels, made from crosslinked copolymers, trap therapeutics at physiological pH and release them in lower pH environments, enhancing biocompatibility and targeted delivery. Background The delivery of small...
Published: 9/6/2024   |   Inventor(s): Nicholas Peppas, William Liechty
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Biomaterials
Precision bioprinting robot for bio-ink deposition and analysis
A bioprinting robotic system uses a robotic arm with a bioprinting tool to deposit bio-ink for tissue repair. It includes sensors, a 3D camera, and a head-mounted display for precise control and real-time feedback, ensuring accurate and safe bioprinting. Background The field of bioprinting technology is a subset of tissue engineering that utilizes...
Published: 8/22/2024   |   Inventor(s): Farshid Alambeigi, Samad Ahadian, Ali Khademhosseini
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Biomaterials
Metabolic engineering of Yarrowia lipolytica for high‑level polyketide production
Background The field of biotechnology has seen significant advancements in the use of genetically modified organisms to produce valuable compounds. Polyketides, a diverse class of secondary metabolites, are of particular interest due to their wide-ranging applications in pharmaceuticals, bioactive compounds, and renewable chemicals. Traditional methods...
Published: 7/11/2024   |   Inventor(s): Hal Alper, Kelly Markham, Claire Palmer
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Ultrasound-programmable nanoparticles for targeted drug release
Background/problem Ideally, a drug meant to accurately target specific tissues or cells involved in a disease will do so and achieve an optimal dose and treatment duration. These will yield the intended cellular and physiological response without undue off-target and side effects. And yet, we live with the reality and risks of side effects. Novel...
Published: 8/15/2024   |   Inventor(s): Wenliang Wang, Huiliang Wang, Yanshu Shi, Banglin Chen
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Biomaterials
Stretchable hybrid response pressure sensor
Background Electronic skins, e-skins for short, is innovative soft electronics technology that gives robots and devices tactile sensing capabilities like human touch and feel. Robots equipped with human touch sensitivity could be deployed in many different applications ranging from manufacturing and food handling/preparation to medical care and surgery,...
Published: 6/28/2024   |   Inventor(s): Nanshu Lu, Kyoung-Ho Ha
Keywords(s):  
Category(s): Life sciences > Medical technology, Life sciences, Life sciences > Biomaterials, Computer software > Digital health, Computer software > Robotics
Biomimetic high-strength bone implant polymer material
Problem Bone defects are a global issue affecting millions, caused by factors such as trauma, aging, disease, surgical resections, and congenital abnormalities. There are natural and synthetic options for bone grafts or replacement. A natural bone graft may come from the patient or a donor and is surgically inserted and provides a surface for the remaining...
Published: 4/12/2024   |   Inventor(s): Wei Li, Hanyu Zhu, Vincent Wang
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Synthetic biology
Recognitive hydrogel technology for precise molecular detection
Background The field of chemical sensor technology has long sought methods to accurately detect and measure molecular presence and concentration in various environments. A pervasive challenge has been developing sensors that can selectively recognize specific molecules in complex mixtures. Traditional sensors often struggle with non-specific binding,...
Published: 9/24/2024   |   Inventor(s): Nicholas Peppas, Carolyn Bayer
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Diagnostic
Chameleon NanoCluster Beacons for single N6-adenosine methylation detection
Problem N6-methyladenosine (m6A) is the most prevalent modification found on eukaryotic mRNA. This modification is implicated in the development of cancer, stem cell differentiation, control of circadian rhythm, and more. m6A bases cannot be detected directly by sequencing, because the m6A modification does not change the base pairing properties and...
Published: 12/8/2023   |   Inventor(s): Hsin-Chih (Tim) Yeh, Judy Obliosca, Yu-An Chen, Cong Liu, Yen-Liang Liu
Keywords(s):  
Category(s): Life sciences > Biomaterials, Life sciences > Research tools > Tool/assay/screening platform
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