Search Results - lawrence+bergman

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Cymanquines: Metallo-Chloroquine Therapeutics
Inhibition of autophagy has become an attractive target for the clinical management of drug resistant cancers. Towards this end, the potent anti-malarial chloroquine (CQ) has been explored as an autophagy inhibitor in multiple studies. Unfortunately, CQ’s inability to exhibit cytotoxic effects in the low PH tumor microenvironment has presented...
Published: 4/30/2025   |   Inventor(s): William Geiger, Kevin Lam, Claire Verschraegen, Jon Ramsey, Lawrence Bergman
Keywords(s):  
Category(s): Technology Classifications > Biomedical
Mechanism-based small-molecule parasite inhibitors
PAGE TITLE Small molecule inhibitors of Plasmodium falciparum for antimalarial therapy PAGE SUMMARY There are an estimated 200 million people infected with malaria annually, with an estimated 400,000-500,000 deaths, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current...
Published: 2/19/2025   |   Inventor(s): Lawrence Bergman, Akhil Vaidya, William Welsh, Sandhya Kortagere
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
Plasmodium liver stage antigens
PAGE TITLE Plasmodium liver stage antigens for malaria vaccine and diagnostics PAGE SUMMARY There are an estimated 200-300 million people infected with malaria annually, with a mortality rate of 1-3%, and 40% of the world’s population at risk of contracting the disease. While the RTS,S (Mosquirix, GSK) recombinant protein-based vaccine is...
Published: 2/19/2025   |   Inventor(s): Lawrence Bergman, Stefan Kappe, Patrick Duffy, Urszula Krzych, Donald Heppner, Vladislav Malkov, Alice Tarun, Jason Wendler, Igor Bacik
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics
Use of cymanquine compounds as antimalarial agents
PAGE SUMMARY There are an estimated 200-300 million people infected with malaria annually, with a mortality rate of 1-3%, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments, there are drug-resistant parasites emerging, underscoring the need for the next generation...
Published: 2/19/2025   |   Inventor(s): Lawrence Bergman, William Geiger, Kevin Lam
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics