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Cymanquines: Metallo-Chloroquine Therapeutics
Inhibition of autophagy has become an attractive target for the clinical management of drug resistant cancers. Towards this end, the potent anti-malarial chloroquine (CQ) has been explored as an autophagy inhibitor in multiple studies. Unfortunately, CQ’s inability to exhibit cytotoxic effects in the low PH tumor microenvironment has presented...
Published: 2/25/2025   |   Inventor(s): William Geiger, Kevin Lam, Claire Verschraegen, Jon Ramsey
Keywords(s):  
Category(s): Technology Classifications > Biomedical
Use of cymanquine compounds as antimalarial agents
PAGE SUMMARY There are an estimated 200-300 million people infected with malaria annually, with a mortality rate of 1-3%, and 40% of the world’s population at risk of contracting the disease. While artemisinin and mosquito reduction are the current treatments, there are drug-resistant parasites emerging, underscoring the need for the next generation...
Published: 2/19/2025   |   Inventor(s): Lawrence Bergman, William Geiger, Kevin Lam
Keywords(s):  
Category(s): Pharmaceuticals & Therapeutics