Search Results - podocyte

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Construct for Tetracycline Inducible Podocyte Specific Gene Expression in Mice
The National Institutes of Health announces the generation of a construct by ligating 2.5kb human podocin promoter sequence to gene encoding reverse tetracycline-controlled transcriptional activator which enables tetracycline-inducible podocyte specific gene of interest expression with another construct consisting of tetracycline responsive element,...
Published: 10/28/2024   |   Inventor(s): Jeffrey Kopp
Keywords(s): CONSTRUCT, Expression, Gene, IDXXXX, INDUCIBLE, IXXXXX, Mice, Podocyte, Specific, Tetracycline
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
Conditionally Immortalized Human Podocyte Cell Lines
Podocytes, cells of the visceral epithelium in the kidneys, are a key component of the glomerular filtration barrier. Podocyte damage and loss contribute to the initiation of glomerular diseases. NIH investigators recently established long-term urinary cell cultures from two patients with focal segmental glomerulosclerosis and two healthy volunteers,...
Published: 10/28/2024   |   Inventor(s): Toru Sakairi, Jeffrey Kopp
Keywords(s): Cell, Conditionally, ESTABLISHED, Human, IDXXXX, immortalized, IXXXXX, Lines, Podocyte, RXXXXX, Urine
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, Application > Therapeutics