Search Results - jeevan+govindharajulu

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Diagnostic Assay for Determining Patient Response to Apoptosis-related Cancer Therapy
Abstract: Many known chemotherapeutic drugs kill abnormal cells through a process called apoptosis. Bcl-2 proteins are negative regulators of apoptosis that control cell survival and death. Increased expression of anti-apoptotic Bcl-2 proteins commonly occurs in up to 30% of all cancers, providing cancer cells a pro-survival advantage to evade cell...
Published: 4/8/2024   |   Inventor(s): Apurva Srivastava, Dominic Esposito, Jeevan Govindharajulu, Ralph Parchment, James Doroshow
Keywords(s): APOPTOSIS, BCL-2, IMMUNOASSAY, Pharmacodynamic Biomarkers, Pro-Apoptotic, prognostic, Srivastava
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Diagnostics, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
Nature-inspired Functionally-graded UHMWPE + Kevlar Composites Achieve Extraordinarily High Strength
Nature-inspired polymers are achieved using unique processing to yield functional gradient composites with embedded Kevlar fibers exhibiting extraordinarily high strength lightweight UHMWPE materials. Background: Demand for new energy absorption materials and implantable polymeric biomaterials has increased significantly in recent years. The...
Published: 10/17/2024   |   Inventor(s): Shenqiang Ren, Lu An
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Nanotechnology, Technology Classifications > Engineering
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024   |   Inventor(s): Soung Chang Liew, Lu LU, Lizhao You
Keywords(s): Network Coding, Wireless Local Area Network
Category(s): Information and Communications Technology